The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
권호 표지

Pathophysiology and Diagnosis of Irritable Bowel Syndrome

과민성장증후군의 병태생리와 진단

  • Kang, Hye-Won (Department of Internal Medicine, Ewha Womans University School of Medicine) ;
  • Jung, Hye-Kyung (Department of Internal Medicine, Ewha Womans University School of Medicine)
  • 강혜원 (이화여자대학교 의학전문대학원 내과학교실) ;
  • 정혜경 (이화여자대학교 의학전문대학원 내과학교실)
  • Published : 2011.05.01
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Abstract

Irritable bowel syndrome (IBS) is a very common functional gastrointestinal disorder characterized by abdominal pain ordiscomfort with bowel habit changes. However, its pathogenesis and pathyphysiology have been poorly understood. Therewere many robust functional and anatomical evidences in Korea for visceral hypersensitivity, low-grade inflammation andimmunologic alterations, brain-gut interaction and genetic factors in the development of IBS. The link between pathophysiologicchanges and gastrointestinal symptoms would be the strong basis for the relevance of target therapy in this condition. The ROME IIIcriteria represent the current gold standard for the identification of characteristic and supportive symptoms of IBS and for thecategorization of IBS patients into symptom-based subgroups with exclusion of organic diseases. There were some limitations inuse of Rome III criteria in the clinical practice and research fields. Test of Rome III are needed, especially in Korea.

Keywords

References

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