Clinical Endoscopy

  • 제44권1호
  • /
  • Pages.22-26
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  • 2011
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  • 2234-2400(pISSN)
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  • 2234-2443(eISSN)
대한소화기내시경학회 (The Korean Society of Gastrointestinal Endoscopy)
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Comparison of Midazolam Alone versus Midazolam Plus Propofol during Endoscopic Submucosal Dissection

  • Cho, Young-Shim (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Seo, Eui-Keun (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Han, Jung-Ho (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Yoon, Soon-Man (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Chae, Hee-Bok (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Park, Seon-Mee (Department of Internal Medicine, Chungbuk National University College of Medicine) ;
  • Youn, Sei-Jin (Department of Internal Medicine, Chungbuk National University College of Medicine)
  • 발행 : 2011.09.30
⟨ 이전 논문 다음 논문 ⟩

초록

Background/Aims: For proper sedation during endoscopic submucosal dissection (ESD), propofol has been widely used. This study aimed to compare the levels of sedation and tolerance of patients treated with midazolam (M group) and a combination of midazolam and propofol (MP group) during ESD. Methods: A total of 44 consecutive patients undergoing ESD were randomly assigned to the two groups. In the M group, 2 mg of midazolam was given repeatedly to maintain after a loading dose of 5 mg. The MP group initially received 5 mg of midazolam and 20 mg of propofol. Then, we increased the dosage of propofol by 20 mg gradually. Results: The average amount of midazolam was 12 mg in the M group. In the M group, 10 patients were given propofol additionally, since they failed to achieve proper sedation. The average amount of propofol was 181 mg in the MP group. Procedure time, vital signs and rates of complications were not significantly different between two groups. Movement of patients and discomfort were lower in the MP group. Conclusions: During ESD, treatment with propofol and a low dose of midazolam for sedation provides greater satisfaction for endoscopists compared to midazolam alone.

키워드

참고문헌

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피인용 문헌

  1. Safety and Efficacy of Deep Sedation with Propofol Alone or Combined with Midazolam Administrated by Nonanesthesiologist for Gastric Endoscopic Submucosal Dissection vol.6, pp.4, 2011, https://doi.org/10.5009/gnl.2012.6.4.464
  2. Endoscopist-Directed Propofol: Pros and Cons vol.47, pp.2, 2014, https://doi.org/10.5946/ce.2014.47.2.129
  3. Efficacy and safety of a patient-positioning device (EZ-FIX) for endoscopic retrograde cholangiopancreatography vol.21, pp.19, 2011, https://doi.org/10.3748/wjg.v21.i19.5995