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Prevalence of Unruptured Intracranial Aneurysm on MR Angiography

  • Jeon, Tae-Yeon (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Jeon, Pyoung (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Keon-Ha (Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • Published : 2011.10.01

Abstract

Objective: To evaluate the prevalence of incidentally found unruptured intracranial aneurysms (UIAs) on the brain MR angiography (MRA) from a community-based general hospital. Materials and Methods: This was a prospectively collected retrospective study, carried out from January 2004 to December 2004. The subjects included 3049 persons from a community-based hospital in whom MRA was performed according to a standardized protocol in an outpatient setting. Age- and sex-specific prevalence of UIAs was calculated. The results by MRA were compared with intra-arterial digital subtraction angiography (DSA) findings. Results: Unruptured intracranial aneurysms were found in 137 (5%) of the 3049 patients (M:F = 43:94; mean age, 60.2 years). The prevalence of UIAs was 5% (n = 94) in women and 4% (n = 43) in men, respectively (p = 0.2046) and showed no age-related increase. The most common site of aneurysm was at the distal internal carotid artery (n = 64, 39%), followed by the middle cerebral artery (n = 40, 24%). In total, 99% of aneurysms measured less than 12 mm, and 93% of aneurysms measured less than 7 mm. Direct comparisons between MRA and DSA were available in 70 patients with 83 UIAs; the results revealed two false positive and two false negative results. Conclusion: This community-hospital based study suggested a higher prevalence of UIAs observed by MRA than previously reported. These findings should be anticipated in the design and use of neuroimaging in clinical practice.

Keywords

References

  1. Stehbens WE. Aneurysms and anatomical variation of cerebral arteries. Arch Pathol 1963;75:45-64
  2. Stehbens WE. Pathology of the cerebral blood vessels. St. Louis: C.V. Mosby, 1972
  3. Rinkel GJ, Djibuti M, Algra A, van Gijn J. Prevalence and risk of rupture of intracranial aneurysms: a systematic review. Stroke 1998;29:251-256 https://doi.org/10.1161/01.STR.29.1.251
  4. Housepian EM, Pool JL. A systematic analysis of intracranial aneurysms from the autopsy file of the Presbyterian Hospital, 1914 to 1956. J Neuropathol Exp Neurol 1958;17:409-423 https://doi.org/10.1097/00005072-195807000-00001
  5. Chason JL, Hindman WM. Berry aneurysms of the circle of Willis; results of a planned autopsy study. Neurology 1958;8:41-44
  6. Iwamoto H, Kiyohara Y, Fujishima M, Kato I, Nakayama K, Sueishi K, et al. Prevalence of intracranial saccular aneurysms in a Japanese community based on a consecutive autopsy series during a 30-year observation period. The Hisayama study. Stroke 1999;30:1390-1395 https://doi.org/10.1161/01.STR.30.7.1390
  7. Rocque BG, Baskaya MK, Kuo JS. Incidental findings on brain MRI. N Engl J Med 2008;358:853; author reply 854-855 https://doi.org/10.1056/NEJMc073320
  8. Horikoshi T, Akiyama I, Yamagata Z, Nukui H. Retrospective analysis of the prevalence of asymptomatic cerebral aneurysm in 4518 patients undergoing magnetic resonance angiography-- when does cerebral aneurysm develop? Neurol Med Chir (Tokyo) 2002;42:105-112; discussion 113 https://doi.org/10.2176/nmc.42.105
  9. Ross JS, Masaryk TJ, Modic MT, Ruggieri PM, Haacke EM, Selman WR. Intracranial aneurysms: evaluation by MR angiography. AJNR Am J Neuroradiol 1990;11:449-455
  10. White PM, Wardlaw JM, Easton V. Can noninvasive imaging accurately depict intracranial aneurysms? A systematic review. Radiology 2000;217:361-370
  11. Chung TS, Joo JY, Lee SK, Chien D, Laub G. Evaluation of cerebral aneurysms with high-resolution MR angiography using a section-interpolation technique: correlation with digital subtraction angiography. AJNR Am J Neuroradiol 1999;20:229-235
  12. Grandin CB, Mathurin P, Duprez T, Stroobandt G, Hammer F, Goffette P, et al. Diagnosis of intracranial aneurysms: accuracy of MR angiography at 0.5 T. AJNR Am J Neuroradiol 1998;19:245-252
  13. Yue NC, Longstreth WT Jr, Elster AD, Jungreis CA, O'Leary DH, Poirier VC. Clinically serious abnormalities found incidentally at MR imaging of the brain: data from the Cardiovascular Health Study. Radiology 1997;202:41-46
  14. Mallouhi A, Felber S, Chemelli A, Dessl A, Auer A, Schocke M, et al. Detection and characterization of intracranial aneurysms with MR angiography: comparison of volumerendering and maximum-intensity-projection algorithms. AJR Am J Roentgenol 2003;180:55-64 https://doi.org/10.2214/ajr.180.1.1800055
  15. Vernooij MW, Ikram MA, Tanghe HL, Vincent AJ, Hofman A, Krestin GP, et al. Incidental findings on brain MRI in the general population. N Engl J Med 2007;357:1821-1828 https://doi.org/10.1056/NEJMoa070972
  16. Inagawa T, Hirano A. Autopsy study of unruptured incidental intracranial aneurysms. Surg Neurol 1990;34:361-365 https://doi.org/10.1016/0090-3019(90)90237-J
  17. Wiebers DO, Whisnant JP, Huston J 3rd, Meissner I, Brown RD Jr, Piepgras DG, et al. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 2003;362:103-110 https://doi.org/10.1016/S0140-6736(03)13860-3
  18. Guglielmi G, Vinuela F, Dion J, Duckwiler G. Electrothrombosis of saccular aneurysms via endovascular approach. Part 2: Preliminary clinical experience. J Neurosurg 1991;75:8-14 https://doi.org/10.3171/jns.1991.75.1.0008
  19. Russell SM, Lin K, Hahn SA, Jafar JJ. Smaller cerebral aneurysms producing more extensive subarachnoid hemorrhage following rupture: a radiological investigation and discussion of theoretical determinants. J Neurosurg 2003;99:248-253 https://doi.org/10.3171/jns.2003.99.2.0248
  20. Hwang JH, Roh HG, Chun YI, Kang HS, Choi JW, Moon WJ, et al. Endovascular coil embolization of very small intracranial aneurysms. Neuroradiology 2011;53:349-357 https://doi.org/10.1007/s00234-010-0735-0
  21. van Rooij WJ, Keeren GJ, Peluso JP, Sluzewski M. Clinical and angiographic results of coiling of 196 very small (< or = 3 mm) intracranial aneurysms. AJNR Am J Neuroradiol 2009;30:835-839 https://doi.org/10.3174/ajnr.A1429
  22. Gupta V, Chugh M, Jha AN, Walia BS, Vaishya S. Coil embolization of very small (2 mm or smaller) berry aneurysms: feasibility and technical issues. AJNR Am J Neuroradiol 2009;30:308-314
  23. Inagawa T, Hada H, Katoh Y. Unruptured intracranial aneurysms in elderly patients. Surg Neurol 1992;38:364-370 https://doi.org/10.1016/0090-3019(92)90023-G
  24. Chae KS, Jeon P, Kim KH, Kim ST, Kim HJ, Byun HS. Endovascular coil embolization of very small intracranial aneurysms. Korean J Radiol 2010;11:536-541 https://doi.org/10.3348/kjr.2010.11.5.536
  25. Okahara M, Kiyosue H, Yamashita M, Nagatomi H, Hata H, Saginoya T, et al. Diagnostic accuracy of magnetic resonance angiography for cerebral aneurysms in correlation with 3D-digital subtraction angiographic images: a study of 133 aneurysms. Stroke 2002;33:1803-1808 https://doi.org/10.1161/01.STR.0000019510.32145.A9

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