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Acute Generalized Exanthematous Pustulosis Due to Oral Use of Blue Dyes

  • Sener, Osman (Division of Allergy, Department of Internal Medicine, Gulhane Military Medical Academy and Medical School) ;
  • Kose, Osman (Department of Dermatology, Gulhane Military Medical Academy and Medical School) ;
  • Kartal, Ozgur (Division of Allergy, Department of Internal Medicine, Gulhane Military Medical Academy and Medical School) ;
  • Safali, Mukerrem (Department of Pathology, Gulhane Military Medical Academy and Medical School)
  • Published : 2011.09.01

Abstract

Acute generalized exanthematous pustulosis is a rare severe pustular cutaneous adverse reaction characterized by a rapid clinical course with typical histological findings. It is accompanied by fever and acute eruption of non-follicular pustules overlying erythrodermic skin. The causative agents are most frequently antibacterial drugs. We present a patient with acute generalized exanthematous pustulosis caused by methylene blue and indigotin dyes.

Keywords

References

  1. Roujeau JC, Bioulac-Sage P, Bourseau C, et al. Acute generalized exanthematous pustulosis: analysis of 63 cases. Arch Dermatol 1991;127:1333-1338. https://doi.org/10.1001/archderm.1991.01680080069004
  2. Naides SJ, Piette W, Veach LA, Argenyi Z. Human parvovirus B19-induced vesiculopustular skin eruption. Am J Med 1988;84:968-972. https://doi.org/10.1016/0002-9343(88)90081-2
  3. Roujeau JC. Clinical heterogeneity of drug hypersensitivity. Toxicology 2005;209:123-129. https://doi.org/10.1016/j.tox.2004.12.022
  4. Simmons R, Thevarajah S, Brennan MB, Christos P, Osborne M. Methylene blue dye as an alternative to isosulfan blue dye for sentinel lymph node localization. Ann Surg Oncol 2003;10:242-247. https://doi.org/10.1245/ASO.2003.04.021
  5. Jelovsek JE, Chiung C, Chen G, Roberts SL, Paraiso MF, Falcone T. Incidence of lower urinary tract injury at the time of total laparoscopic hysterectomy. JSLS 2007;11:422-427.
  6. Ikeda T, Jinno H, Fujii H, Kitajima M. Recent development of sentinel lymph node biopsy for breast cancer in Japan. Asian J Surg 2004;27:275-278. https://doi.org/10.1016/S1015-9584(09)60050-6
  7. Oliveira Neto AM, Duarte NM, Vicente WV, Viaro F, Evora PR. Methylene blue: an effective treatment for contrast medium-induced anaphylaxis. Med Sci Monit 2003;9:CS102-CS106.
  8. Camp NE. Methemoglobinemia. J Emerg Nurs 2007;33:172-174. https://doi.org/10.1016/j.jen.2006.11.007
  9. Keller B, Yawalkar N, Pichler C, Braathen LR, Hunger RE. Hypersensitivity reaction against patent blue during sentinel lymph node removal in three melanoma patients. Am J Surg 2007;193:122-124. https://doi.org/10.1016/j.amjsurg.2006.03.013
  10. Jeudy G, Louvier N, Rapennes T, et al. Immediate patent blueinduced hypersensitivity during sentinel node detection: the value of cutaneous tests. Ann Dermatol Venereol 2008;135:461-465. https://doi.org/10.1016/j.annder.2007.12.017
  11. Yusim Y, Livingstone D, Sidi A. Blue dyes, blue people: the systemic effects of blue dyes when administered via different routes. J Clin Anesth 2007;19:315-321. https://doi.org/10.1016/j.jclinane.2007.01.006
  12. Thomas E, Bellon T, Barranco P, et al. Acute generalized exanthematous pustulosis due to tetrazepam. J Investig Allergol Clin Immunol 2008;18:119-122.
  13. Roujeau JC. Neutrophilic drug eruptions. Clin Dermatol 2000;18:331-337. https://doi.org/10.1016/S0738-081X(99)00124-8
  14. Wolkenstein P, Chosidow O, Flechet ML, et al. Patch testing in severe cutaneous adverse drug reactions, including Stevens-Johnson syndrome and toxic epidermal necrolysis. Contact Dermatitis 1996;35:234-236. https://doi.org/10.1111/j.1600-0536.1996.tb02364.x

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