The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Acute Lymphoblastic Leukemia in Elderly Patients: A Single Institution's Experience

  • Shin, Dong-Yeop (Department of Internal Medicine, Seoul National University Hospital) ;
  • Kim, In-Ho (Department of Internal Medicine, Seoul National University Hospital) ;
  • Kim, Ki-Hwan (Department of Internal Medicine, Seoul Municipal Boramae Hospital) ;
  • Choi, You-Nak (Department of Internal Medicine, Seoul National University Hospital) ;
  • Beom, Seung-Hoon (Department of Internal Medicine, Seoul National University Hospital) ;
  • Yang, Yae-Won (Department of Internal Medicine, Seoul National University Hospital) ;
  • Lim, Yoo-Joo (Department of Internal Medicine, Seoul National University Hospital) ;
  • Lee, Eun-Young (Department of Internal Medicine, Seoul National University Hospital) ;
  • Lee, June-Koo (Department of Internal Medicine, Seoul National University Hospital) ;
  • Kim, Ji-Yeon (Department of Internal Medicine, Seoul National University Hospital) ;
  • Kim, Hyun-Kyung (Department of Laboratory Medicine, Seoul National University College of Medicine) ;
  • Yoon, Sung-Soo (Department of Internal Medicine, Seoul National University Hospital) ;
  • Lee, Dong-Soon (Department of Laboratory Medicine, Seoul National University College of Medicine) ;
  • Park, Seon-Yang (Department of Internal Medicine, Seoul National University Hospital) ;
  • Kim, Byoung-Kook (Department of Internal Medicine, Seoul National University Hospital)
  • Published : 2011.09.01
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Abstract

Background/Aims: We investigated the clinical characteristics and prognosis of elderly patients with acute lymphoblastic leukemia (ALL). Methods: We reviewed the clinical data, laboratory findings, bone marrow findings, and cytogenetic analysis of elderly patients (${\geq}$ 60 years) with ALL, and data of an additional 101 younger adult patients (< 60 years) with ALL were reviewed for comparison. Results: Twenty-six elderly patients (${\geq}$ 60 years) and 101 younger adult patients (< 60 years) with ALL were retrospectively enrolled. The median follow-up duration was 6.0 months (range, 0.4 to 113.2) in the elderly patients and 21.7 months (range, 1.0 to 122.7) in the adult patients. In total, 34.6% (9 patients) of the elderly patients and 24.8% (25 patients) of the adult patients had Philadelphia chromosome positive ALL. The overall complete remission (CR) rate was much higher in the younger than in the elderly patients (94.1% vs. 57.7%, p < 0.001). The median overall survival (OS) of the younger patients (< 60 years) was 26.3 months, whereas that of the elderly patients (${\geq}$ 60 years) was 10.3 months (p = 0.003). In the elderly patients with ALL, T cell lineage and the presence of lymphadenopathy were significant prognostic factors for OS in a univariate analysis (p = 0.033 and 0.041, respectively). Conclusions: The outcomes of Korean elderly patients with ALL were poor, and the shorter OS was mainly due to the low CR rate. T-cell lineage and the presence of lymphadenopathy were significant prognostic factors in Korean elderly patients with ALL.

Keywords

References

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