The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Comparison of Clinical Outcomes of Hydrophilic and Lipophilic Statins in Patients with Acute Myocardial Infarction

  • Kim, Min-Chul (The Heart Center of Chonnam National University Hospital) ;
  • Ahn, Young-Keun (The Heart Center of Chonnam National University Hospital) ;
  • Jang, Su-Young (The Heart Center of Chonnam National University Hospital) ;
  • Cho, Kyung-Hoon (The Heart Center of Chonnam National University Hospital) ;
  • Hwang, Seung-Hwan (The Heart Center of Chonnam National University Hospital) ;
  • Lee, Min-Goo (The Heart Center of Chonnam National University Hospital) ;
  • Ko, Jum-Suk (The Heart Center of Chonnam National University Hospital) ;
  • Park, Keun-Ho (The Heart Center of Chonnam National University Hospital) ;
  • Sim, Doo-Sun (The Heart Center of Chonnam National University Hospital) ;
  • Yoon, Nam-Sik (The Heart Center of Chonnam National University Hospital) ;
  • Yoon, Hyun-Ju (The Heart Center of Chonnam National University Hospital) ;
  • Kim, Kye-Hun (The Heart Center of Chonnam National University Hospital) ;
  • Hong, Young-Joon (The Heart Center of Chonnam National University Hospital) ;
  • Park, Hyung-Wook (The Heart Center of Chonnam National University Hospital) ;
  • Kim, Ju-Han (The Heart Center of Chonnam National University Hospital) ;
  • Jeong, Myung-Ho (The Heart Center of Chonnam National University Hospital) ;
  • Cho, Jeong-Gwan (The Heart Center of Chonnam National University Hospital) ;
  • Park, Jong-Chun (The Heart Center of Chonnam National University Hospital) ;
  • Kang, Jung-Chaee (The Heart Center of Chonnam National University Hospital)
  • Published : 2011.09.01
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Abstract

Background/Aims: A controversy exists about which statin is preferable for patients with acute myocardial infarction (AMI), and clinical impacts of different statins according to lipophilicity have not been established. Methods: The 1,124 patients with AMI included in the present study were divided into hydrophilic- and lipophilic-statin groups. In-hospital complications (defined as death, cardiogenic shock, ventricular arrhythmia, infection, bleeding, and renal insufficiency, and other fatal arrhythmias), major adverse cardiac events (MACE), all-cause death, re-myocardial infarction, re-percutaneous coronary intervention (re-PCI), and surgical revascularization were analyzed during a 1-year clinical follow-up. Results: Baseline characteristics were similar between the two groups, and in-hospital complication rates showed no between-group differences (11.7% vs. 12.8%, p = 0.688). Although MACE at the 1- and 6-month clinical follow-ups occurred more in hydrophilic statin group I (1 month: 10.0% vs. 4.4%, p = 0.001; 6 month: 19.9% vs. 14.2%, p = 0.022), no significant difference in MACE was observed at the 1-year follow-up (21.5% vs. 17.9%, p = 0.172). Both statin groups showed similar efficacy for reducing serum lipid concentrations. A Cox-regression analysis showed that the use of a hydrophilic statin did not predict 1-year MACE, all-cause death, AMI, or re-PCI. Conclusions: Although short-term cardiovascular outcomes were better in the lipophilic-statin group, 1-year outcomes were similar in patients with AMI who were administered hydrophilic and lipophilic statins. In other words, the type of statin did not influence 1-year outcomes in patients with AMI.

Keywords

References

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