The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
권호 표지

Case of Breast Cancer in a Neurofibromatosis 2 Patient

신경섬유종증 2형에 동반된 유방암 1예

  • Ahn, Se-Jin (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences) ;
  • Kang, Hye-Jin (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences) ;
  • Lee, Seung-Sook (Department of Pathology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences) ;
  • Yang, Gi-Young (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences) ;
  • Lee, Tae-Hyeon (Department of Radiology, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences) ;
  • Lee, Jong-Hwan (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences) ;
  • Kim, Hyung-Jin (Department of Internal Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences)
  • 안세진 (한국원자력의학원 원자력병원 내과) ;
  • 강혜진 (한국원자력의학원 원자력병원 내과) ;
  • 이승숙 (한국원자력의학원 원자력병원 병리과) ;
  • 양기영 (한국원자력의학원 원자력병원 내과) ;
  • 이태현 (한국원자력의학원 원자력병원 영상의학과) ;
  • 이종환 (한국원자력의학원 원자력병원 내과) ;
  • 김형진 (한국원자력의학원 원자력병원 내과)
  • Published : 2011.04.01
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Abstract

Neurofibromatosis 2 is a multiple neoplasia syndrome that is caused by mutations in the NF2 tumor suppressor gene on chromosome 22q12. Bilateral vestibular nerve schwannomas are the distinctive feature of neurofibromatosis 2. There have been no reported cases of breast cancer in patients with neurofibromatosis 2. We recently encountered a case of breast cancer in a 46-year-old woman with neurofibromatosis 2. She had had a palpable right beast mass for the previous year andtinnitus in her left ear for the previous 6 months. She was diagnosed with breast cancer (invasive ductal carcinoma) with metastasis to the lungs, bones and stomach. MRI of the brain revealed nodules in both internal auditory canals, indicating that she was suffering from neurofibromatosis 2. After radiation therapy for compression fractures in T8 and L1, and one cycle of chemotherapy, the patient died of febrile neutropenia and pneumonia.

저자들은 신경섬유종증 2형에 동반된 46세 여자 환자의 유방암 1예를 경험하였기에 문헌고찰과 함께 보고하고자 하는 바이다. 신경섬유종증 2형과 유방암과의 연관성이 아직 명확히 밝혀지지 않았으나, 신경섬유종증 2형에 동반될 수 있는 악성 종양으로 유방암이 발생할 수 있고 더 강한 침습성과 나쁜 예후의 가능성이 있음을 고려해야 할 것으로 생각한다.

Keywords

References

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