The Korean Journal of Medicine

  • 제80권4호
  • /
  • Pages.473-476
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  • 2011
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  • 1738-9364(pISSN)
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  • 2289-0769(eISSN)
대한내과학회 (The Korean Association of Internal Medicine)
권호 표지

혈액투석으로 성공적으로 치료한 메포르민 유산산증 2예

Two Cases of Metformin-Induced Lactic Acidosis Successfully Treated by Hemodialysis

  • 강병일 (순천향대학교 천안병원 내과학교실) ;
  • 김수지 (순천향대학교 천안병원 내과학교실) ;
  • 김정훈 (순천향대학교 천안병원 내과학교실) ;
  • 길효욱 (순천향대학교 천안병원 내과학교실) ;
  • 양종오 (순천향대학교 천안병원 내과학교실) ;
  • 이은영 (순천향대학교 천안병원 내과학교실) ;
  • 홍세용 (순천향대학교 천안병원 내과학교실)
  • Kang, Byung-Il (Department of Internal Medicine, Soonchunhyang University Hospital) ;
  • Kim, Su-Ji (Department of Internal Medicine, Soonchunhyang University Hospital) ;
  • Kim, Jung-Hoon (Department of Internal Medicine, Soonchunhyang University Hospital) ;
  • Gil, Hyo-Wook (Department of Internal Medicine, Soonchunhyang University Hospital) ;
  • Yang, Jong-Oh (Department of Internal Medicine, Soonchunhyang University Hospital) ;
  • Lee, Eun-Young (Department of Internal Medicine, Soonchunhyang University Hospital) ;
  • Hong, Sae-Yong (Department of Internal Medicine, Soonchunhyang University Hospital)
  • 발행 : 2011.04.01
⟨ 이전 논문 다음 논문 ⟩

초록

저자들은 자살목적으로 과량의 메포르민 음독 후에 발생한 유산산증과 신기능 저하상태에서 지속적으로 복용 중 발생한 유산산증을 혈액투석을 통해 성공적으로 치료된 증례를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

Metformin-induced lactic acidosis is a rare life-threatening complication associated with metformin treatment and has a high mortality rate. Here, two cases of metformin-induced lactic acidosis are reported. A 22-year-old woman was admitted to our hospital with a metformin overdose (25 g) and lactic acidosis. Hemodialysis was initiated to correct the acidemia, and the patient showed full recovery. Her serum creatinine level returned to normal. A 50-year-old man presented with a 5-day history of muscle weakness. His medical history included diabetes mellitus for 6 years treated with metformin at 3,000 mg/day and hypertension. An arterial blood sample showed metabolic acidosis, with a venous lactate level of 31.1 mg/dL. The patient recovered fully after treatment with bicarbonate dialysis. These cases illustrate that the presence of clinical conditions such as renal failure increase the risk of metformin-induced lactic acidosis. Prompt recognition of lactic acidosis and early treatment with bicarbonate dialysis can result in a successful clinical outcome.

키워드

참고문헌

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