A Case of Trophoblastic Tumor Associated with Papillary Thyroid Cancer

융모 상피성 종양을 진단받은 환자에서 발병한 갑상선 유두암 1예

  • Kim, Jae-Hyun (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Kim, Song-Yi (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Lee, Mi-Young (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Shin, Jang-Yel (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Shin, Young-Goo (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Chung, Choon-Hee (Department of Internal Medicine, Yonsei University Wonju College of Medicine)
  • 김재현 (연세대학교 원주의과대학 내과학교실) ;
  • 김송이 (연세대학교 원주의과대학 내과학교실) ;
  • 이미영 (연세대학교 원주의과대학 내과학교실) ;
  • 신장열 (연세대학교 원주의과대학 내과학교실) ;
  • 신영구 (연세대학교 원주의과대학 내과학교실) ;
  • 정춘희 (연세대학교 원주의과대학 내과학교실)
  • Published : 2011.04.01

Abstract

Thyroid cancer is one of the most common endocrine malignancies. It is known that thyroid cancer can develop during reproductive periods, possibly due to the effects of sex hormones and growth factors such human chorionic gonadotrophin (HCG). Some data suggest that elevated HCG levels during pregnancy or gestational trophoblastic disease can stimulate thyroid cellular proliferation and promote cancer formation; however, a case of papillary thyroid cancer accompanied by a gestational trophoblastic tumor has not been reported. Here, we report the case of a 44-year-old woman with papillary thyroid cancer during treatment for a gestational trophoblastic tumor.

갑상선 암은 가장 흔한 내분비암 중 하나이다. 갑상선은 성호르몬과 ${\beta}-HCG$ 등의 영향을 받기 때문에 ${\beta}-HCG$가 증가되는 임신시나 융모 상피성 질환에서 갑상선 질환의 발생이 촉진 될 수 있다고 알려져 왔다. 하지만 융모 상피성 종양 환자에서 갑상선 암이 동반된 경우는 아직까지 국내에서 보고되지 않았다. 이에 저자는 융모 상피성 종양 환자에서 갑상선 유두암이 동반된 사례를 경험하였기에 문헌고찰과 함께 보고한다.

Keywords

References

  1. Kim MJ, Park SS, Park CW, et al. Clinical features and prognosis in pregnant women with thyroid cancer. Korean J Obstet Gynecol 2005;48:296-303.
  2. Bae JS, Hong SW, Yoon WH, Chang ES, Suh KS. A clinical study on patient with thyroid cancer. J Korean Cancer Assoc 1996;28:78-87.
  3. Lee SJ, Hong SJ, Lee PR, Shong YK. Clinical features of well differentiated thyroid carcinomas in pregnant women. J Korean Soc Endocrinol 2001;16:140-147.
  4. Hershman JM, Braverman LE, Utiger RD. Werner and Ingbar's the Thyroid. 7th ed. Lippincott Williams & Wilkins: Philadelphia, PA, USA, 1995:573-576.
  5. Nisula BC, Taliadouros GS. Thyroid function in gestational trophoblastic neoplasia: evidence that the thyrotropic activity of chorionic gonadotropin mediates the thyrotoxicosis of choriocarcinoma. Am J Obstet Gynecol 1980;138:77-85. https://doi.org/10.1016/0002-9378(80)90014-9
  6. Pierce JG, Parsons TF. Glycoprotein hormones: structure and function. Annu Rev Biochem 1981;50:465-495. https://doi.org/10.1146/annurev.bi.50.070181.002341
  7. Smits G, Govaerts C, Nubourgh I, Pardo L, Vassart G, Costagliola S. Lysine 183 and glutamic acid 157 of the TSH receptor: two interacting residues with a key role in determining specificity toward TSH and human CG. Mol Endocrinol 2002;16:722-735. https://doi.org/10.1210/me.16.4.722
  8. Hershman JM. Physiological and pathological aspects of the effect of human chorionic gonadotropin on the thyroid. Best Pract Res Clin Endocrinol Metab 2004;18:249-265. https://doi.org/10.1016/j.beem.2004.03.010
  9. Orgiazzi J, Rousset B, Cosentino C, Tourniaire J, Dutrieux N. Plasma thyrotropic activity in a man with choriocarcinoma. J Clin Endocrinol Metab 1974;39:653-657. https://doi.org/10.1210/jcem-39-4-653
  10. Rosen IB, Walfish PG. Pregnancy as a predisposing factor in thyroid neoplasia. Arch Surg 1986;121:1287-1290. https://doi.org/10.1001/archsurg.1986.01400110077013
  11. Yoshimura M, Nishikawa M, Yoshikawa N, et al. Mechanism of thyroid stimulation by human chorionic gonadotropin in sera of normal pregnant women. Acta Endocrinol (Copenh) 1991;124:173-178.
  12. Jaklic BR, Rushin J, Ghosh BC. Estrogen and progesterone receptors in thyroid lesions. Ann Surg Oncol 1995;2:429-434. https://doi.org/10.1007/BF02306376
  13. del Senno L, degli Uberti E, Hanau S, Piva R, Rossi R, Transforini G. In vitro effects of estrogen on tgb and c-myc gene expression in normal and neoplastic human thyroids. Mol Cell Endocrinol 1989;63:67-74. https://doi.org/10.1016/0303-7207(89)90082-8
  14. Greenman DL, Highman B, Chen J, Sheldon W, Gass G. Estrogen-induced thyroid follicular cell adenomas in C57BL/6 mice. J Toxicol Environ Health 1990;29:269-278. https://doi.org/10.1080/15287399009531390