대한영상의학회지 (Journal of the Korean Society of Radiology)

  • 제64권6호
  • /
  • Pages.567-575
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  • 2011
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  • 1738-2637(pISSN)
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  • 2288-2928(eISSN)
대한영상의학회 (The Korean Society of Radiology)
권호 표지

다발성골수종의 골외 발현

A Pictorial Review on Extraosseous Manifestations of Multiple Myelomas

  • 서정민 (성균관의대 삼성서울병원 영상의학과) ;
  • 이경수 (성균관의대 삼성서울병원 영상의학과) ;
  • 이진아 (성균관의대 삼성서울병원 영상의학과) ;
  • 김성현 (성균관의대 삼성서울병원 영상의학과) ;
  • 박병관 (성균관의대 삼성서울병원 영상의학과) ;
  • 한부경 (성균관의대 삼성서울병원 영상의학과) ;
  • 김형진 (성균관의대 삼성서울병원 영상의학과)
  • Seo, Jung-Min (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Lee, Kyung-Soo (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Yi, Chin-A (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Seong-Hyun (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Park, Byung-Kwan (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Han, Boo-Kyung (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Hyung-Jin (Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 발행 : 2011.06.01
⟨ 이전 논문 다음 논문 ⟩

초록

약 10-20%의 다발성골수종 환자에서 처음 진단 시에 골외 침범이 발견되며 질병의 경과 중 15%의 환자에서 골외 침범이 더 발견된다. 골외 다발성골수종은 신체의 어느 부위에서도 발병할 수 있고 더 침습적이고 예후가 좋지 않은 것으로 알려져 있다. 골외 다발성골수종의 영상의학적 소견은 다양한데, CT에서는 조영 증강이 잘 되고 T1과 T2 강조 영상에서는 동신호강도를 보이며, PET에서는 다양한 정도의 (18F-fluorine deoxyglucose (FDG))흡수를 보인다. 이 질환은 다발성골수종 자체에 의한 혹은 조혈모세포 이식 후에 발생할 수 있는 감염 질환으로 오인될 수 있어 이와의 감별을 요한다.

Extraosseous involvement of multiple myelomas can be seen clinically or radiologically in approximately 10-20% of patients at the time of initial diagnosis and may develop in an additional 15% of patients over the course of the disease. The condition can arise in any tissue of the body and its presence has been associated with more aggressive disease, a guarded prognosis, or high-dose chemotherapy. Imaging findings of extraosseous multiple myelomas are diverse. They usually show high enhancement on contrast-medium enhanced CT scans, exhibit iso-signal intensity on both T1- and T2-weighted images, and variable 18F-fluorine deoxyglucose (FDG) uptake at PET. The disease may simulate an infectious condition since it may be concurrent with underlying multiple myelomas per se or it may occur during myeloma treatment including stem cell transplantation.

키워드

참고문헌

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