십이지장 유두부에 발생한 선편평 상피암종 1예

A Case of Adenosquamous Carcinoma of the Ampulla of Vater

  • 김홍준 (울산대학교 의과대학 서울아산병원 소화기내과학교실) ;
  • 이성구 (울산대학교 의과대학 서울아산병원 소화기내과학교실) ;
  • 장지웅 (울산대학교 의과대학 서울아산병원 소화기내과학교실) ;
  • 류충헌 (울산대학교 의과대학 서울아산병원 소화기내과학교실) ;
  • 박도현 (울산대학교 의과대학 서울아산병원 소화기내과학교실) ;
  • 이상수 (울산대학교 의과대학 서울아산병원 소화기내과학교실) ;
  • 서동완 (울산대학교 의과대학 서울아산병원 소화기내과학교실) ;
  • 김명환 (울산대학교 의과대학 서울아산병원 소화기내과학교실)
  • Kim, Hong-Jun (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Sung-Koo (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Jang, Ji-Woong (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Ryu, Choong-Heon (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Park, Do-Hyun (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Lee, Sang-Soo (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Seo, Dong-Wan (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine) ;
  • Kim, Myung-Hwan (Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine)
  • 발행 : 2011.06.30

초록

56세 남자가 복부 불편감과 식욕저하를 주소로 내원하였다. 전산화 단층촬영에서 원위담도 부위에 종괴를 의심하였고 십이지장내시경에서 십이지장 유두부의 종괴를 관찰하였다. 수술 후 선편평 상피암종으로 진단하였고 경과 관찰 중 18개월 후 시행한 복부 전산화 단층촬영에서 전이성 림프절을 관찰하였다. 십이지장 유두부에 발생하는 선편평 상피암종은 매우 드문 질환으로 저자들은 1예를 경험하여 문헌고찰과 함께 보고한다.

Primary adenosquamous carcinoma arising from the papilla of Vater is an extremely rare tumor. Here we report a case of adenosquamous carcinoma of the duodenal major papilla. The patient was a 56-year-old man presenting with abdominal discomfort and anorexia. A computed tomography (CT) scan showed dilatation of the common bile duct (CBD) and both intrahepatic ducts with a suspicious mass in the distal CBD. Duodenoscopy revealed a mass with an irregular surface at the papilla. The patient underwent Whipple's operation. He was diagnosed as having adenosquamous carcinoma of the papilla of Vater. Eighteen months after pancreaticoduodenectomy, metastatic lymph nodes were noted in a follow-up CT scan.

키워드

참고문헌

  1. Heinrich S, Clavien PA. Ampullary cancer. Curr Opin Gastroenterol 2010;26:280-285. https://doi.org/10.1097/MOG.0b013e3283378eb0
  2. Song HG, Yoo KS, Ju NR, et al. A case of adenosquamous carcinoma of the papilla of Vater. Korean J Gastroenterol 2006;48:132-136.
  3. Lee DK, Park CK, Ahn GH, et al. Adenosquamous carcinoma of the ampulla of vater: a report of two cases. Korean J Pathol 2006;40:160-164.
  4. Teramoto T, Kawamata H, Fujimori T. How does adenosquamous carcinoma arise in the small intestine? J Gastroenterol 2003;38:810-811. https://doi.org/10.1007/s00535-003-1192-x
  5. Wada T, Mizuno K, Itoh K, et al. Adenosquamous carcinoma of the jejunum. J Gastroenterol 2003;38:786-790. https://doi.org/10.1007/s00535-002-1147-7
  6. Yachida S, Nakanishi Y, Shimoda T, et al. Adenosquamous carcinoma of the esophagus. Clinicopathologic study of 18 cases. Oncology 2004;66:218-225. https://doi.org/10.1159/000077998
  7. Ngo N, Villamil C, Macauley W, Cole SR. Adenosquamous carcinoma of the small intestine. Report of a case and review of the literature. Arch Pathol Lab Med 1999;123:739-742.
  8. Boswell JT, Helwig EB. Squamous cell carcinoma and adenoacanthoma of the stomach. A clinicopathologic study. Cancer 1965;18:181-192. https://doi.org/10.1002/1097-0142(196502)18:2<181::AID-CNCR2820180209>3.0.CO;2-3
  9. Crissman JD. Adenosquamous and squamous cell carcinoma of the colon. Am J Surg Pathol 1978;2:47-54. https://doi.org/10.1097/00000478-197803000-00006
  10. Straus R, Heschel S, Fortmann DJ. Primary adenosquamous carcinoma of the stomach. A case report and review. Cancer 1969;24:985-995. https://doi.org/10.1002/1097-0142(196911)24:5<985::AID-CNCR2820240518>3.0.CO;2-4
  11. Yavuz E, Kapran Y, Ozden I, Bulut T, Dizdaroglu F. Pancreatobiliary adenosquamous carcinoma (report of two cases). Pathologica 2000;92:323-326.
  12. Petrelli NJ, Valle AA, Weber TK, Rodriguez-Bigas M. Adenosquamous carcinoma of the colon and rectum. Dis Colon Rectum 1996;39:1265-1268. https://doi.org/10.1007/BF02055120
  13. Iemura A, Yano H, Mizoguchi A, Kojiro M. A cholangiocellular carcinoma nude mouse strain showing histologic alteration from adenocarcinoma to squamous cell carcinoma. Cancer 1992;70:415-422. https://doi.org/10.1002/1097-0142(19920715)70:2<415::AID-CNCR2820700208>3.0.CO;2-9
  14. Ueno N, Sano T, Kanamaru T, et al. Adenosquamous cell carcinoma arising from the papilla major. Oncol Rep 2002;9:317-320.
  15. Fischer HP, Zhou H. Pathogenesis of carcinoma of the papilla of vater. J Hepatobiliary Pancreat Surg 2004;11:301-309. https://doi.org/10.1007/s00534-004-0898-3