Parasites, Hosts and Diseases

The Korea Society for Parasitology and Tropical Medicine (대한기생충학·열대의학회)
권호 표지
DOI QR코드

DOI QR Code

Hypersensitive Reaction to Praziquantel in a Clonorchiasis Patient

  • Lee, Jung-Min (Department of Parasitology and Tropical Medicine, and Institute of Endemic Diseases, Medical Research Center, Seoul National University College of Medicine) ;
  • Lim, Hyun-Sul (Department of Preventive Medicine, Dongguk University College of Medicine) ;
  • Hong, Sung-Tae (Department of Parasitology and Tropical Medicine, and Institute of Endemic Diseases, Medical Research Center, Seoul National University College of Medicine)
  • Received : 2010.07.03
  • Accepted : 2011.08.03
  • Published : 2011.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Praziquantel is the drug of choice for clonorchiasis. Since clonorchiasis is endemic in most river basins, praziquantel has been widely used for 30 years in Korea. A 54-year-old Korean woman suffered from hypersensitive reactions, such as nausea, dyspnea, rash, and urticaria after taking the first dose of praziquantel to treat clonorchiasis. She ingested one dose again and the same symptoms appeared, and she was treated at a clinic with anti-histamines. She tried one more dose with anti-histamines but found the same symptoms. Later, she was found to pass eggs of Clonorchis sinensis and medicated with flubendazole. The hypersensitive reaction to praziquantel is rare but occurs. This is the 5th case report in the world.

Keywords

References

  1. Hong ST, Fang Y. Clonorchis sinensis and clonorchiasis, an update. Parasitol Int 2011; Jun 30. [Epub ahead of print].
  2. Kyung SY, Cho YK, Kim YJ, Park JW, Jeong SH, Lee JI, Sung YM, Lee SP. A paragonimiasis patient with allergic reaction to praziquentel and resistance to triclabendazole: Successful treatment after desensitization to praziquantel. Korean J Parasitol 2011; 49: 73-77. https://doi.org/10.3347/kjp.2011.49.1.73
  3. Shen C, Choi MH, Bae YM, Yu G, Wang S, Hong ST. A case of anaphylactic reaction to praziquantel treatment. Am J Trop Med Hyg 2007; 76: 603-605.
  4. Huang SW. A clinical approach to a patient with praziquantel hypersensitivity. J Allergy Clin Immunol 1992; 90: 867. https://doi.org/10.1016/0091-6749(92)90114-H
  5. Liu T. Allergic manifestation after pyquiton treatment of schistosomiasis. Chinese J Parasitol Parasit Dis 1984; 2: 192, 203.
  6. Matsumoto J. Adverse effect of praziquantel teatment of Schistosoma japonicum infection: Involvement of host anaphylactic reaction induced by parasite antigen release. Int J Parasitol 2002; 32: 461-471. https://doi.org/10.1016/S0020-7519(01)00368-X
  7. Hong ST, Lee SH, Lee SJ, Kho WG, Lee M, Li S, Chung BS, Seo M, Choi MH. Sustained-release praziquantel tablet: Pharmacokinetics and the treatment of clonorchiasis in beagle dogs. Parasitol Res 2003; 91: 316-320. https://doi.org/10.1007/s00436-003-0958-7
  8. Shen C, Kim J, Lee JK, Bae YM, Choi MH, Oh JK, Lim MK, Shin HR, Hong ST. Collection of Clonorchis sinensis adult worms from infected humans after praziquantel treatment. Korean J Parasitol 2007; 45: 149-152. https://doi.org/10.3347/kjp.2007.45.2.149

Cited by

  1. Praziquantel Treatment in Trematode and Cestode Infections: An Update vol.45, pp.1, 2011, https://doi.org/10.3947/ic.2013.45.1.32
  2. An EF-handed Ca2+-binding protein of Chinese liver fluke Clonorchis sinensis vol.112, pp.12, 2011, https://doi.org/10.1007/s00436-013-3603-0
  3. Treatment of Schistosomiasis in a Patient Allergic to Praziquantel: A Desensitization and Treatment Protocol vol.95, pp.5, 2011, https://doi.org/10.4269/ajtmh.16-0462
  4. Current status and perspectives of Clonorchis sinensis and clonorchiasis: epidemiology, pathogenesis, omics, prevention and control vol.5, pp.1, 2011, https://doi.org/10.1186/s40249-016-0166-1
  5. Albendazole and Praziquantel: Review and Safety Monitoring in Korea vol.50, pp.1, 2011, https://doi.org/10.3947/ic.2018.50.1.1
  6. Case Report: Acute Generalized Exanthematous Pustulosis Caused by Praziquantel vol.100, pp.3, 2019, https://doi.org/10.4269/ajtmh.18-0832
  7. Histone deacetylase enzymes as potential drug targets of Neglected Tropical Diseases caused by cestodes vol.9, pp.None, 2011, https://doi.org/10.1016/j.ijpddr.2019.02.003
  8. Evaluation of anthelminthic activity of both pomegranate peels and Artemisia herba-Alba extracts in comparison with praziquantel in experimentally infected mice with Hymenolepis nana vol.26, pp.2, 2011, https://doi.org/10.4103/kamj.kamj_29_20
  9. Amino acids serve as an important energy source for adult flukes of Clonorchis sinensis vol.14, pp.4, 2011, https://doi.org/10.1371/journal.pntd.0008287
  10. Practical Guidance for the Evaluation and Management of Drug Hypersensitivity: Specific Drugs vol.8, pp.9, 2020, https://doi.org/10.1016/j.jaip.2020.08.006
  11. The potential for histone deacetylase (HDAC) inhibitors as cestocidal drugs vol.15, pp.3, 2011, https://doi.org/10.1371/journal.pntd.0009226
  12. Novel mechanism of hepatobiliary system damage and immunoglobulin G4 elevation caused by Clonorchis sinensis infection vol.9, pp.23, 2011, https://doi.org/10.12998/wjcc.v9.i23.6639