Clinical Endoscopy

  • 제42권2호
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  • Pages.113-117
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  • 2011
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  • 2234-2400(pISSN)
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  • 2234-2443(eISSN)
대한소화기내시경학회 (The Korean Society of Gastrointestinal Endoscopy)
권호 표지

전통적 거치상샘종에서 발생한 조기 대장 샘암종 1예

Early Adenocarcinoma Arising from Traditional Serrated Adenoma in the Colon

  • 김민경 (경희대학교 의과대학 강동경희대학교병원 내과학교실) ;
  • 차재명 (경희대학교 의과대학 강동경희대학교병원 내과학교실) ;
  • 임성직 (경희대학교 의과대학 강동경희대학교병원 내과학교실) ;
  • 김선용 (경희대학교 의과대학 강동경희대학교병원 내과학교실) ;
  • 채정민 (경희대학교 의과대학 강동경희대학교병원 내과학교실) ;
  • 조욱 (경희대학교 의과대학 강동경희대학교병원 내과학교실) ;
  • 주광로 (경희대학교 의과대학 강동경희대학교병원 내과학교실) ;
  • 이정일 (경희대학교 의과대학 강동경희대학교병원 내과학교실)
  • Kim, Min-Kyung (Department of Internal Medicine, Gang Dong Kyung Hee University Hospital, Kyunghee University College of Medicine) ;
  • Cha, Jae-Myung (Department of Internal Medicine, Gang Dong Kyung Hee University Hospital, Kyunghee University College of Medicine) ;
  • Lim, Sung-Jig (Department of Internal Medicine, Gang Dong Kyung Hee University Hospital, Kyunghee University College of Medicine) ;
  • Kim, Sun-Yong (Department of Internal Medicine, Gang Dong Kyung Hee University Hospital, Kyunghee University College of Medicine) ;
  • Chae, Jung-Min (Department of Internal Medicine, Gang Dong Kyung Hee University Hospital, Kyunghee University College of Medicine) ;
  • Jo, Uk (Department of Internal Medicine, Gang Dong Kyung Hee University Hospital, Kyunghee University College of Medicine) ;
  • Joo, Kwang-Ro (Department of Internal Medicine, Gang Dong Kyung Hee University Hospital, Kyunghee University College of Medicine) ;
  • Lee, Joung-Il (Department of Internal Medicine, Gang Dong Kyung Hee University Hospital, Kyunghee University College of Medicine)
  • 발행 : 2011.02.27
⟨ 이전 논문 다음 논문 ⟩

초록

거치상샘종은 미소위성체 불안정성을 보이는 대장 샘암종의 전구 병변이다. 거치상샘종으로부터 발생하는 대장암은 전통적인 샘종-샘암종 경로와 다른 대장암화 경로인 거치상 신생물 대장암화 경로로 악성화가 발현되는 것으로 알려져 있다. 약 10~15%의 대장암이 거치상 신생물 대장암화를 통해 악성화하며, 미소위성체 불안전성 기전을 통해 발생한다고 알려져 있다. 거치상샘종으로부터 발생한 대장암 증례들이 최근 드물지 않게 관찰되고 있지만, 이런 개념들이 비교적 최근에 정립되었기 때문에 국내에서 보고된 예는 매우 드물었다. 저자들은 특별한 증상 없이 건강검진 목적으로 시행한 대장내시경 검사에서 구불결장의 전통적거치상샘종으로부터 발생한 대장 샘암종을 내시경 폴립절제술을 통해 확진하고 치료한 증례를 문헌 고찰과 함께 보고한다.

A serrated adenoma is a precursor lesion for some cases of microsatellite unstable colorectal carcinoma (CRC). The serrated neoplasia pathway has been associated with carcinogenesis of serrated adenoma, which is different from the traditional adenoma-carcinoma sequence. The serrated neoplasia pathway accounts for 10~15% of CRCs, and these tumors typically demonstrate microsatellite instability. Cases of a CRC arising from a serrated adenoma have been rarely identified with the recent recognition of the serrated neoplasia pathway. However, these cases are not frequently reported in Korea, because this concept has only been recently emphasized. We report a case of an early adenocarcinoma arising from a traditional serrated adenoma of the colon, which was diagnosed and treated by a colonoscopic polypectomy.

키워드

참고문헌

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