Recurrent Superficial Pyoderma Caused by Mixed Infection of Proteus mirabilis and Staphylococcus pseudointermedius in a Yorkshire Terrier Dog

요크셔테리어종 개에 발생한 Proteus mirabilis와 Staphylococcus pseudointermedius혼합 감염에 의한 재발성표재성농피증 증례

  • Jeong, Hyo-Hoon (College of Veterinary Medicine, Kyungpook National University) ;
  • Oh, Tae-Ho (College of Veterinary Medicine, Kyungpook National University)
  • Accepted : 2011.09.09
  • Published : 2011.10.31

Abstract

An 8-year-old spayed Yorkshire Terrier Dog was presented to the Veterinary Teaching Hospital of Kyungpook National University because of the recurrent superficial pyoderma. At the presentation, pustules and papules were present throughout the body. Numerous rods with a few cocci were observed on impression smears and they were confirmed to be Proteus mirabilis and Staphylococcus pseudointermedius consecutively. The patient was treated with systemic enrofloxacin and amoxicillin-clavulanic acid based on the results of antimicrobial sensitivity tests with once a week basis 4% chlorhexidine shampoo. An excellent clinical response was achieved in 2 weeks of therapy and the lesions were fully resolved in 6 weeks. The possibility of P. mirabilis infection should not be overlooked by clinicians in dogs with recurrent superficial pyoderma although it's been considered to be rare.

8세의 중성화 수술을 한 요크셔테리어종견이 재발성표재성농피증을 호소하여 경북대학교 수의과대학 부속동물병원에 내원하였다. 내원 당시 전신에 다수의 농포와 구진이 관찰되었다. 농포의 압착도말염색 표본에서 다수의 간 균과 상대적으로 적은 수의 구균이 함께 관찰되어, 각각 세균을 분리 동정한 결과 Proteus mirabilis와 Staphylococcus pseudointermedius으로 확인되었다. 4% 농도의 클로르헥시딘 샴푸 약욕과 항생제감수성시험 결과에 의한 전신 enrofloxacin과 amoxicillin-clavulanic acid 치료를 병행한 결과 2주 후에는 임상증상이 현저히 개선되었고, 6주 후에는 임상증상이 완전히 사라졌다. 본 증례는 개에서 일반적인 항생제 치료에 응답하지 않는 재발성농피증의 경우 그람음성 간균의 혼합감염 가능성을 시사하였다.

Keywords

References

  1. Cox HU, Hoskins JD, Newman SS, Foil CS, Turnwald GH, Roy AF. Temporal study of staphylococcal species on healthy dogs. Am J Vet Res 1988; 49: 747-751.
  2. DeBoer DJ. Strategies for management of recurrent pyoderma in dogs. Vet Clin North Am Small Anim Pract 1990; 20: 1509-1524. https://doi.org/10.1016/S0195-5616(90)50158-8
  3. Devriese LA, Vancanneyt M, Baele M, Vaneechoutte M, De Graef E, Snauwaert C, Cleenwerck I, Dawyndt P, Swings J, Decostere A, Haesebrouck F. Staphylococcus pseudintermedius sp. nov., a coagulase-positive species from animals. Int J Syst Evol Microbiol 2005; 55: 1569-1573. https://doi.org/10.1099/ijs.0.63413-0
  4. Guaguere E. Topical treatment of canine and feline pyoderma. Vet Dermatol 1996; 7: 145-151. https://doi.org/10.1111/j.1365-3164.1996.tb00239.x
  5. Hill PB, Moriello KA. Canine pyoderma. J Am Vet Med Assoc 1994; 204: 334-340.
  6. Hillier A, Alcorn JR, Cole LK, Kowalski JJ. Pyoderma caused by Pseudomonas aeruginosa infection in dogs: 20 cases. Vet Dermatol 2006; 17: 432-439. https://doi.org/10.1111/j.1365-3164.2006.00550.x
  7. Horspool LJ, van Laar P, van den Bos R, Mawhinney IC. Clinical efficacy of two ibafloxacin formulations in the treatment of canine pyoderma. Vet Rec 2006; 158: 236-237. https://doi.org/10.1136/vr.158.7.236
  8. Ihrke PJ, Papich MG, Demanuelle TC. The use of fluoroquinolones in veterinary dermatology. Vet Dermatol 1999; 10: 193-204. https://doi.org/10.1046/j.1365-3164.1999.00179.x
  9. Lloyd DH, Allaker RP, Pattinson A. Carriage of Staphylococcus intermedius on the ventral abdomen of clinically normal dogs and those with pyoderma. Vet Dermatol 1991; 2: 161-164. https://doi.org/10.1111/j.1365-3164.1991.tb00127.x
  10. Lloyd DH, Lamport AI. Activity of chlorhexidine shampoos in vitro against Staphylococcus intermedius, Pseudomonas aeruginosa and Malassezia pachydermatis. Vet Rec 1999; 144:536-537. https://doi.org/10.1136/vr.144.19.536
  11. Medleau L, Long RE, Brown J, Miller WH. Frequency and antimicrobial susceptibility of Staphylococcus species isolated from canine pyodermas. Am J Vet Res 1986; 47: 229-231.
  12. Pedersen K, Pedersen K, Jensen H, Finster K, Jensen VF, Heuer OE. Occurrence of antimicrobial resistance in bacteria from diagnostic samples from dogs. J Antimicrob Chemother 2007; 60: 775-781. https://doi.org/10.1093/jac/dkm269
  13. Ross Fitzgerald J. The Staphylococcus intermedius group of bacterial pathogens: species re-classification, pathogenesis and the emergence of meticillin resistance. Vet Dermatol 2009; 20: 490-495. https://doi.org/10.1111/j.1365-3164.2009.00828.x
  14. Rycroft AK, Saben HS. A clinical study of otitis externa in the dog. Can Vet J 1977; 18: 64-70.
  15. Scott DW, Miller WH, Griffin CE. Bacterial Skin Diseases. In:Small animal dermatology, 6th ed. Philadelphia: WB Saunders; 2001: 274-335.
  16. Toma S, Colombo S, Cornegliani L, Persico P, Galzerano M, Gianino MM, Noli C. Efficacy and tolerability of once daily cephalexin in canine superficial pyoderma: an open controlled study. J Small Anim Pract 2008; 49: 384-391. https://doi.org/10.1111/j.1748-5827.2008.00585.x
  17. Wildermuth BE, Griffin CE, Rosenkrantz WS, Boord MJ. Susceptibility of Pseudomonas isolates from the ears and skin of dogs to enrofloxacin, marbofloxacin, and ciprofloxacin. J Am Anim Hosp Assoc 2007; 43: 337-341. https://doi.org/10.5326/0430337