YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Anti-platelet Aggregation Study of Fermented Galgeun Tang and Fermented Ssanghwa Tang

발효 갈근탕과 쌍화탕의 혈소판 응집 억제 효과 연구

  • 손추영 (충남대학교 약학대학 임상약학실) ;
  • 송병정 (충남대학교 약학대학 임상약학실) ;
  • 마진열 (한국 한의학 연구원) ;
  • 권광일 (충남대학교 약학대학 임상약학실)
  • Received : 2011.06.07
  • Accepted : 2011.08.23
  • Published : 2011.10.31
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Abstract

This study was performed to evaluate enhanced effect of fermented Galgeun tang (GGT) and Ssanghwa tang (SHT) on the anti-platelet aggregation. Platelet aggregation assay was performed In vitro using human platelet rich plasma(PRP) and In vivo using SD-rat plasma by platelet aggregometer. Pharmacodynamic parameters, $E_{max}$ and $EC_{50}$, were calculated using Winnolin. SD-rats administered 1 g/kg of oriental medicine every 12 hr for 8 days. Platelet aggregation was measured by optical method with collagen inducer (4 ${\mu}g$/ml). In In vitro anti-platelet study, $EC_{50}$ of GGT-A was lower than that of GGT-con about 79.13 ${\mu}g$/ml. And $EC_{50}$ of SHT-A and SHT-B was lower than that of SHT-con about 122.73 and 110.15 ${\mu}g$/ml, respectively. It is assumed that fermented GGT and SHT were more effective than original medicine. In multiple administration study, anti-platelet effect was significantly increased both GGT and SHT. Fermented GGT and SHT were more effective than original herbal medicine on anti-platelet aggregation.

Keywords

References

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