YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis of Anti-inflammatory 2'-Hydroxychalcone Derivatives

항염증효과를 갖는 2'-하이드록시찰콘 유도체의 합성

  • Lee, Young-Sook (College of Pharmacy, Institute of Pharmaceutical Research and Development, Wonkwang University) ;
  • Kim, Hak-Sung (College of Pharmacy, Institute of Pharmaceutical Research and Development, Wonkwang University)
  • 이영숙 (원광대학교 약학대학 약품연구소) ;
  • 김학성 (원광대학교 약학대학 약품연구소)
  • Received : 2011.09.19
  • Accepted : 2011.09.21
  • Published : 2011.10.31
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Abstract

It was reported that the potency of TMMC derivatives was related to the presence of the 2'-hydroxy group on the A ring. Also, 4-dimethylamino group on the B ring lowered the anti-inflammatory potency of the chalcones. We synthesized various derivatives of 2'-hydroxy chalcones having other substituents on B ring. The synthetic derivatives showed the more potent anti-inflammatory effect, comparable to that of the TMMC derivatives reported previously.

Keywords

References

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