Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제37권5호
  • /
  • Pages.386-395
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  • 2011
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
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골다공증 유도 백서경골에 티타늄 임플란트 매식 시 저출력 초음파 적용이 골 치유에 미치는 영향

Effect of low intensity pulsed ultrasound (LIPUS) on bone healing around a titanium implant in the tibia of osteoporosis-induced rats

  • 황영섭 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 전현준 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 신상훈 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 정인교 (부산대학교 치의학전문대학원 구강악안면외과학교실) ;
  • 김규천 (부산대학교 치의학전문대학원 구강해부학교실) ;
  • 김철훈 (동아대학교 의료원 치과 구강악안면외과) ;
  • 김욱규 (부산대학교 치의학전문대학원 구강악안면외과학교실)
  • Hwang, Young-Seob (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Jeon, Hyun-Jun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Shin, Sang-Hun (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Chung, In-Kyo (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University) ;
  • Kim, Gyoo-Cheon (Department of Oral Anatomy, School of Dentistry, Pusan National University) ;
  • Kim, Chul-Hoon (Department of Oral and Maxillofacial Surgery, Department of Dentistry, Dong-A University Medical Center) ;
  • Kim, Uk-Kyu (Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University)
  • 투고 : 2011.03.10
  • 심사 : 2011.08.24
  • 발행 : 2011.10.31
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초록

Introduction: Osteoporosis is a major health problem in the elderly that involves changes in the properties of bone as well as impaired bone healing around a titanium implant in both humans and animals. This study examined effect of low intensity pulsed ultrasound (LIPUS) on the bone healing process around a titanium implant in osteoporosis-induced rats. Materials and Methods: Sixteen rats were divided into two groups. A control group with osteoporosis induced by removing both ovaries and an experimental group of rats that were applied with LIPUS after osteoporosis had been induced. A screw type titanium implant (diameter, 2.0 mm: length, 3.5 mm, Cowell-Medi, KOREA) was placed into the tibias of 16 rats. The control and experimental group contained 8 rats each. The rats were sacrificed at 1, 2, 4, and 8 weeks after implantation to examine the histopathology and immunochemistry. Results: The histopathology examination revealed earlier new bone formation in the experimental group than the control group. In particular, at 1 week after implantation, more new bone matrix and collagen were observed around the implant of the experimental group compared to the control group. Immunochemistry analysis showed that the level of OPG expression of the experimental group was higher in the early stages than in the control group. After 8 weeks, the levels of OPG expression were similar in both groups. The expression level of receptor activator of nuclear factor kB ligand (RANKL) was stronger in the experimental group than the control group. After 4 weeks, the level of RANKL expression was similar in both groups. Conclusion: These results suggest that the application of LIPUS to implantation can promote bone healing around titanium in osteoporosis animals.

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참고문헌

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피인용 문헌

  1. Enhancing Effect of Intermittent Parathyroid Hormone Administration on Bone Formation After Titanium Implant Placement in an Ovariectomized Rat Maxilla vol.25, pp.2, 2011, https://doi.org/10.1097/id.0000000000000352