대한디지털의료영상학회논문지 (Korean Journal of Digital Imaging in Medicine)
- 제13권2호
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- Pages.55-58
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- 2011
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- 1976-7641(pISSN)
흰 쥐의 뇌경색 병변에 대한 자기공명영상
Cerebral Infarction Model in Rat on Magnetic Resonance Imaging
- 정지성 (중앙대학교 의료원 영상의학과)
- Jung, Ji-Sung (Department of Radiology, Chung-Ang University Hospital)
- 투고 : 2011.03.11
- 심사 : 2011.04.15
- 발행 : 2011.06.30
초록
It is important to study using experimental animals for research about stroke. Magnetic Resonance Imaging(MRI) is avaluable diagnosticmethods for stroke diagnosis. The purpose of this research is to know the Magnetic Resonance Imaging(MRI) and histopathological characteristics findings after induction of photothrombotic cerebral infarction in rat brain. Male Sprague-Dawley rats were anesthetized, Rose Bengal dye(20 mg/kg) was intravenously injected. The right sensonrimotor cortex of rat brain was exposed to cold light of 7 mm diameter at a position of 1 mm anterior and 3.5 mm lateral to bregma for 20 min. The post-infarction effects were monitored by T1 weighted and T2 weighted images of brain MRI. Histopathological changes were observed after Hematoxylin & Eosin staining. The lesion appeared clearly high signal intensity area on T2 weighted images(the major axis