Bulletin of the Korean Chemical Society

  • 제32권11호
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  • Pages.3914-3922
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  • 2011
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and Antimicrobial Activity of Oxazolone, Imidazolone and Triazine Derivatives Containing Benzothiophene

  • Naganagowda, Gadada (Research Center for Bioorganic Chemistry (RCBC), Department of Chemistry, Faculty of Science, Chulalongkorn University) ;
  • Petsom, Amorn (Research Center for Bioorganic Chemistry (RCBC), Department of Chemistry, Faculty of Science, Chulalongkorn University)
  • 투고 : 2011.04.12
  • 심사 : 2011.09.01
  • 발행 : 2011.11.20
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초록

3-Chloro-1-benzothiophene-2-carbonyl chloride 1 was reacted with glycine in acetone to give 3-chloro-1-benzothiophen-2-yl-carbonylaminoacetic acid 2. Various aldehydes on treatment with compound 2 in acetic anhydride to gave 1,3-oxazol-5-ones 3a-d. These oxazolones was treated with aromatic amines or hydrazides to get various imidazol-4-ones 4a-t or 5a-l. Oxazolones 3a-d was also treated with aromatic hydrazines, expansion of five member oxazole ring to six member triazine ring occurs to yield 1,2,4-triazin-6-ones 6a-h. The structures of all the synthesized compounds were confirmed by spectral data and had been screened for antibacterial activity.

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참고문헌

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피인용 문헌

  1. Design, Synthesis, and Evaluation of the Anticancer Properties of a Novel Series of Imidazolone Fused Pyrazolo[1,5-a]pyrimidine Derivatives vol.54, pp.3, 2016, https://doi.org/10.1002/jhet.2786
  2. 5(4H)-oxazolones: Synthesis and biological activities vol.51, pp.2, 2021, https://doi.org/10.1080/00397911.2020.1825746