Endovacular Exclusion of an Abdominal Aortic Aneurysm in Patients with Concomitant Abdominal Malignancy: Early Experience

복부 대동맥류와 복부 장기 악성종양에 동시에 이환된 환자의 혈관 내 스텐트 삽입결과: 초기 경험

  • Choi, You-Ri (Department of Radiology, Chonnam National University Hwasun Hospital) ;
  • Shin, Hyo-Hyun (Department of Radiology, Chonnam National University Hospital) ;
  • Yim, Nam-Yeol (Department of Radiology, The Armed Forces Yangju Hospital) ;
  • Oh, Hyun-Jun (Department of Radiology, Chonnam National University Hospital) ;
  • Chang, Nam-Kyu (Department of Radiology, Chonnam National University Hwasun Hospital) ;
  • Kim, Jae-Kyu (Department of Radiology, Chonnam National University Hospital) ;
  • Choi, Soo-Jin-Na (Department of Surgery, Chonnam National University Hospital) ;
  • Chung, Sang-Young (Department of Surgery, Chonnam National University Hospital)
  • 최유리 (화순전남대학교병원 영상의학과) ;
  • 신효현 (전남대학교병원 영상의학과) ;
  • 임남열 (국군양주병원 영상의학과) ;
  • 오현준 (전남대학교병원 영상의학과) ;
  • 장남규 (화순전남대학교병원 영상의학과) ;
  • 김재규 (전남대학교병원 영상의학과) ;
  • 최수진나 (전남대학교병원 외과학과) ;
  • 정상영 (전남대학교병원 외과학과)
  • Received : 2010.02.17
  • Accepted : 2010.06.20
  • Published : 2010.10.01

Abstract

Purpose: To assess the outcomes of endovascular aortic aneurysm repair (EVAR) for the treatment of an abdominal aortic aneurysm in patients undergoing curative surgical treatment for concomitant abdominal malignancy. Materials and Methods: The study included 12 patients with abdominal neoplasia and an abdominal aortic aneurysm (AAA), which was treated by surgery and stent EVAR. The neoplasm consisted of the gastric, colorectal, pancreas, prostate, and gall bladder. The follow up period was 3-21 months (mean 11.8 months). All medical records and imaging analyses were reviewed by CTA and/or color Doppler US, retrospectively. Results: Successful endoluminal repair was accomplished in all twelve patients. The mean interval time between EVAR and surgery was 58.6 days. Small amounts of type 2 endoleaks were detected in two patients (17%). One patient developed adult respiratory distress syndrome after Whipple's operation 20 days after surgery, which led to hopeless discharge. No procedure-related mortality, morbidity, or graft-related infection was noted. Conclusion: Exclusion of AAA in patients with accompanying malignancy show with a relatively low procedure morbidity and mortality. Hence, endoluminal AAA repair in patients with synchronous neoplasia may allow greater flexibility in the management of an offending malignancy.

목적: 복부 대동맥류와 복부 장기 악성 종양에 동시에 걸린 환자에서 복부 대동맥류에 대해 시행한 인조혈관스텐트삽입술의 초기 경험에 대해 평가하고자 하였다. 대상과 방법: 복부 대동맥류와 복부 장기 악성 종양으로 인조혈관스텐트삽입술과 종양에 대한 수술적 치료를 받은 환자 12명을 연구 대상으로 하였으며, 이 중 8명은 수술 전에 스텐트를 삽입하였고 4명은 수술 후에 삽입하였다. 나이는 53-82세(평균 71세)이며 남자 11명, 여자 1명이었다. 복부 장기 악성 종양 종류는 위, 결장직장, 췌장, 전립선, 담낭 등이었다. 추적 관찰 기간은 3-21개월(평균 11.8개월)로 전산화단층동맥조영술 또는 색도플러초음파로 검사하였다. 결과: 12명 환자 모두에게 성공적으로 인조혈관스텐트삽입술을 시행하였으며, 인조혈관스텐트 삽입술과 종양 수술과의 시간 간격은 6일에서 180일(평균 58.6일) 이였다. 추적 관찰 기간 도중 2명(17%)의 환자에서 제2형 내강 누출이 있었다. 췌장암 환자 1명에서 수술받은 20일 후 급성성인호흡곤란증후군이 발생하여 회복 가능성 없어 퇴원하였다. 시술 관련 사망이나 스텐트감염 등은 없었다. 결론: 복부 대동맥류와 복부 장기 악성 종양에 동시에 걸린 환자에서 복부 대동맥류에 대한 인조혈관스텐트삽입술을 이용한 혈관 내 중재적 치료법은 낮은 사망률과 적은 합병증을 보이며, 두 질환을 동시에 갖는 환자에서 치료 계획을 세우는 데 있어 도움을 줄 것으로 생각한다.

Keywords

References

  1. Lee JT, Donayre CE, Walot I, Kopchok GE, White RA. Endovascular exclusion of abdominal aortic pathology in patients with concomitant malignancy. Ann Vasc Surg 2002;16:150-156 https://doi.org/10.1007/s10016-001-0151-3
  2. Lin PH, Barshes NR, Albo D, Kougias P, Berger DH, Huynh TT, et al. Concomitant colorectal cancer and abdominal aortic aneurysm: evolution of treatment paradigm in the endovascular era. J Am Coll Surg 2008;206:1065-1075 https://doi.org/10.1016/j.jamcollsurg.2007.12.011
  3. Shalhoub J, Naughton P, Lau N, Tsang JS, Kelly CJ, Leahy AL, et al. Concurrent colorectal malignancy and abdominal aortic aneurysm: a multicentre experience and review of the literature. Eur J Vasc Endovasc Surg 2009;37:544-556 https://doi.org/10.1016/j.ejvs.2009.01.004
  4. Baxter NN, Noel AA, Cherry K, Wolff BG. Management of patients with colorectal cancer and concomitant abdominal aortic aneurysm. Dis Colon Rectum 2002;45:165-170 https://doi.org/10.1007/s10350-004-6138-8
  5. Rivolta N, Piffaretti G, Tozzi M, Lomazzi C, Riva F, Alunno A, et al. Management of simultaneous abdominal aortic aneurysm and colorectal cancer: the rationale of mini-invasive approach. Surg Oncol 2007;16 Suppl 1:S165-S167 https://doi.org/10.1016/j.suronc.2007.10.011
  6. Sharif MA, Lee B, Lau LL, Ellis PK, Collins AJ, Blair PH, et al. Prosthetic stent-graft infection after endovascular abdominal aortic aneurysm repair. J Vasc Surg 2007;46:442-448 https://doi.org/10.1016/j.jvs.2007.05.027
  7. Matsumoto K, Murayama T, Nagasaki K, Osumi K, Tanaka K, Nakamaru M, et al. One-stage surgical management of concomitant abdominal aortic aneurysm and gastric or colorectal cancer. World J Surg 2002;26:434-437 https://doi.org/10.1007/s00268-001-0244-8
  8. Bastounis E, Felekouras E, Arvelakis A, Georgopoulos S,Griniatsos J, Papalambros E. Abdominal aortic aneurysm and hepatocellular carcinoma: a one-stage approach. HPB (Oxford) 2002; 4:195-197 https://doi.org/10.1080/13651820260503882
  9. Kiskinis D, Spanos C, Efthimiopoulos G, Saratzis N, Lazaridis I, Gkinis G. Priority of resection in concomitant abdominal aortic aneurysm (AAA) and colorectal cancer (CRC): review of the literature and experience of our clinic. Tech Coloproctol 2004;8:19-21 https://doi.org/10.1007/s10151-004-0045-9
  10. Komori K, Okadome K, Itoh H, Funahashi S, Sugimachi K. Management of concomitant abdominal aortic aneurysm and gastrointestinal malignancy. Am J Surg 1993;166:108-111 https://doi.org/10.1016/S0002-9610(05)81039-6
  11. Onohara T, Orita H, Toyohara T, Sumimoto K, Wakasugi K, Matsusaka T, et al. Long-term results and prognostic factors after repair of abdominal aortic aneurysm with concomitant malignancy. J Cardiovasc Surg (Torino) 1996;37:1-6
  12. Pedrazzani C, Veraldi GF, Tasselli S, Tomasi I, Bernini M, Giacopuzzi S, et al. Surgical treatment of gastric cancer with coexistent abdominal aortic aneurysm. Personal experience and literature review. Hepatogastroenterology 2006;53:973-975
  13. 이도연. 복부대동맥류의 혈관 내 치료법. In 대한인터벤션영상의학회. 인터벤션영상의학. 서울: 일조각, 2007:292-301
  14. Illuminati G, Calio FG, D'Urso A, Lorusso R, Ceccanei G, Vietri F. Simultaneous repair of abdominal aortic aneurysm and resection of unexpected, associated abdominal malignancies. J Surg Oncol 2004;88:234-239 https://doi.org/10.1002/jso.20149
  15. Swanson RJ, Littooy FN, Hunt TK, Stoney RJ. Laparotomy as a precipitating factor in the rupture of intraabdominal aneurysms. Arch Surg 1980;115:299-304 https://doi.org/10.1001/archsurg.1980.01380030045010
  16. Durham SJ, Steed DL, Moosa HH, Makaroun MS, Webster MW. Probability of rupture of an andominal anortic aneurysm after an unrelated operative procedure: a prospective study. J Vasc Surg 1991;13:248-252 https://doi.org/10.1016/0741-5214(91)90217-I
  17. Trede M, Storz LW, Petermann C, Schiele U. Pitfalls and progress in the management of abdominal aortic aneurysm. World J Surg 1988;12:810-817 https://doi.org/10.1007/BF01655484
  18. Porcellini M, Nastro P, Bracale U, Brearley S, Giordano P. Endovascular versus open surgical repair of abdominal aortic aneurysm with concomitant malignancy. J Vasc Surg 2007;46:16- 23 https://doi.org/10.1016/j.jvs.2006.09.070