Journal of the Korean Society of Radiology (대한영상의학회지)

The Korean Society of Radiology (대한영상의학회)
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The Effect of the Degree of Luminal Contrast-Enhancement on CT Measurement of Plaque Size: A Comparison with T1-weighted Magnetic Resonance Imaging

CT를 이용한 비석회화 죽상경화반의 측정에 있어서 내강의 조영 정도가 미치는 영향에 대한 실험적 연구: T1 강조 자기공명영상과의 비교

  • Choi, Byoung-Wook (Department of Diagnostic Radiology, Department of Cardiovascular Radiology Cardiovascular Center, and Research Institute of Radiological Science, Yonsei University College of Medicine) ;
  • Hur, Jin (Department of Diagnostic Radiology, Department of Cardiovascular Radiology Cardiovascular Center, and Research Institute of Radiological Science, Yonsei University College of Medicine) ;
  • Lee, Hye-Jeong (Department of Diagnostic Radiology, Department of Cardiovascular Radiology Cardiovascular Center, and Research Institute of Radiological Science, Yonsei University College of Medicine) ;
  • Kim, Young-Jin (Department of Diagnostic Radiology, Department of Cardiovascular Radiology Cardiovascular Center, and Research Institute of Radiological Science, Yonsei University College of Medicine) ;
  • Kim, Tae-Hoon (Department of Diagnostic Radiology, Gangnam Severance Hospital, Yonsei University College of Medicine) ;
  • Choe, Kyu-Ok (Department of Diagnostic Radiology, Department of Cardiovascular Radiology Cardiovascular Center, and Research Institute of Radiological Science, Yonsei University College of Medicine)
  • 최병욱 (연세대학교 의과대학 영상의학과, 심장혈관병원 심장영상의학과, 방사선의과학 연구소) ;
  • 허진 (연세대학교 의과대학 영상의학과, 심장혈관병원 심장영상의학과, 방사선의과학 연구소) ;
  • 이혜정 (연세대학교 의과대학 영상의학과, 심장혈관병원 심장영상의학과, 방사선의과학 연구소) ;
  • 김영진 (연세대학교 의과대학 영상의학과, 심장혈관병원 심장영상의학과, 방사선의과학 연구소) ;
  • 김태훈 (연세대학교 의과대학 강남세브란스병원 영상의학과) ;
  • 최규옥 (연세대학교 의과대학 영상의학과, 심장혈관병원 심장영상의학과, 방사선의과학 연구소)
  • Received : 2010.08.11
  • Accepted : 2010.08.24
  • Published : 2010.10.01
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Abstract

Purpose: We studied early and delayed contrast-enhanced CT to determine the effects of the degree of luminal enhancement on the measurement of plaque size compared to T1-weighted MRI. Materials and Methods: T1-weighted MRI and a two-phase contrast-enhanced CT was performed in 5 New Zealand white rabbits with atherosclerosis. Early-phase images were acquired during an expected peak enhancement period of the lumen; delayedphase images were acquired 240 sec after administration of the contrast media. Anteroposterior and lateral luminal diameters (APD, LD), luminal area (LA), total vessel area (TVA), and plaque area (PA) of the aorta were measured on MRI and CT, respectively and compared to each other. Results: A total of 78 slices of the aorta were analyzed. PA, measured on T1-weighted MR images, was significantly greater than PA for both early-phase and delayed-phase CT (p < 0.001). The mean difference in PA was $12.13{\pm}5.52\;mm^2$ (p < 0.001), $11.51{\pm}4.37\;mm^2$ (p < 0.001), $-0.62{\pm}3.87\;mm^2$ (p = 0.159) for MRI vs. early-phase CT, MRI vs. delayed-phase CT, and early-phase CT vs. delayed-phase CT, respectively. Conclusion: Different luminal densities by contrast enhancement do not affect the CT measurement of plaque area for the detection of obstructive coronary artery disease.

목적: 혈관 내강의 조영증강 정도가 CT에서 경화반의 크기의 측정에 영향을 미치는지 알아보기 위하여 조기와 지연기 조영증강 CT를 T1-강조 MRI와 비교하였다. 대상과 방법: 뉴질랜드 흰토끼 5마리의 죽상경화증 대동맥을 이용하였다. T1-강조 영상과 이중 주기 조영증강 CT를 촬영하였다. 조기 CT는 예상되는 내강의 최대 조영증강기에 영상을 얻었고 지연기는 조영제 주입 후 240초 후에 영상을 얻었다. MRI와 CT에서 각각 대동맥의 전후 좌우 내강지름(APD, LD), 내강면적(LA), 혈관전체면적(TVA), 경화반면적(PA)을 측정하고 서로 비교하였다. 결과: 총 78개의 대동맥 절편을 분석하였다. T1-강조 MRI에서 측정한 PA는 조기와 지연기 CT에서 측정한 값보다 유의하게 컸다(p < 0.001). 측정 PA의 평균 차이는 MRI와 조기 CT에서 $12.13{\pm}5.52\;mm^2$ (p < 0.001), MRI와 지연기 CT에서, $11.51{\pm}4.37\;mm^2$ (p < 0.001), 조기 CT와 지연기 CT에서 $-0.62{\pm}3.87\;mm^2$ (p = 0.159)였다. 결론: 조영증강에 의한 혈관내강 밀도의 차이는 경화반면적의 측정에 영향을 미치지 않는다.

Keywords

Acknowledgement

Supported by : Korea Research Foundation Grant

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