Journal of the Korean Society of Radiology (대한영상의학회지)

The Korean Society of Radiology (대한영상의학회)
권호 표지

The Radiologic Features of Cystic versus Noncystic Glioblastoma Multiforme as Significant Prognostic Factors

낭성 다형교모세포종과 비낭성 다형교모세포종 환자의 수술 전 영상의학적 차이와 생존율에 미치는 영향

  • Choi, Seung-Joon (Departments of Radiology, Gachon Medical School, Gil Medical Center) ;
  • Hwang, Hee-Young (Departments of Radiology, Gachon Medical School, Gil Medical Center) ;
  • Kim, Na-Rae (Departments of Pathology, Gachon Medical School, Gil Medical Center) ;
  • Lee, Sheen-Woo (Departments of Radiology, Gachon Medical School, Gil Medical Center) ;
  • Kim, Jeong-Ho (Departments of Radiology, Gachon Medical School, Gil Medical Center) ;
  • Choi, Hye-Young (Departments of Radiology, Gachon Medical School, Gil Medical Center) ;
  • Kim, Hyung-Sik (Departments of Radiology, Gachon Medical School, Gil Medical Center)
  • 최승준 (가천의대부속 길병원 영상의학과) ;
  • 황희영 (가천의대부속 길병원 영상의학과) ;
  • 김나래 (가천의대부속 길병원 병리과) ;
  • 이신우 (가천의대부속 길병원 영상의학과) ;
  • 김정호 (가천의대부속 길병원 영상의학과) ;
  • 최혜영 (가천의대부속 길병원 영상의학과) ;
  • 김형식 (가천의대부속 길병원 영상의학과)
  • Received : 2010.02.15
  • Accepted : 2010.07.22
  • Published : 2010.10.01
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Abstract

Purpose: The purpose of this study was to determine the preoperative radiological characteristic and survival differences of glioblastoma multiforme (GBM) with and without cysts. Materials and Methods: Twenty-one GBMs were collected retrospectively; these tumors were pathologic confirmed as GBM. Based on the preoperative MR imaging, we compared the cystic GBMs with the noncystic GBMs according to the the tumor size, the tumor interface, the tumor wall thickness and peritumoral edema. Results: Seven cases were classified as cystic GBMs and fourteen were noncystic GBMs. The cystic GBMs had a well-defined tumor interface, a less than 2 cm thickness of the tumor wall and less than 40 $cm^3$ thick peritumoral edema as compared to that of the noncystic GBMs. There was a statistically significant difference in age between the patients with cystic tumors and those with noncystic tumors. For the patients with cystic GBMs and noncystic GBMs, median survival time after surgery was 43.8 months and 12.5 months, respectively. Conclusion: The cystic GBMs had a well-defined tumor interface, a thin wall and minimaledema, as compared with that of the noncystic GBMs. The patients with cystic GBMs were significantly younger and they had more favorable survival outcomes than did the patients with noncystic GBMs.

목적: 낭성 다형교모세포종과 비낭성 다형교모세포종 환자의 수술 전 영상의학적 차이와 생존율의 차이를 알아보고자 하였다. 대상과 방법: 조직학적으로 진단된 21명의 다형교모세포종 환자를 대상으로 하였으며 낭성 다형교모세포종과 비낭성 다형교모세포종 환자의 수술 전 MRI에서 종괴의 크기, 종괴와 주변 뇌조직의 경계면, 종괴벽의 두께와 종괴주위 부종의 차이를 비교하였다. 결과: 7명의 낭성 다형교모세포종과 14명의 비낭성 다형교모세포종으로 분류되었으며 낭성 다형교모세포종은 비낭성 다형교모세포종보다 경계가 좋으며 85%에서 2 cm 미만의 종괴벽을 가지고 71%에서 40 $cm^3$ 종괴주위 부종을 동반하였다(p < 0.05). 또한, 낭성 다형교모세포종과 비낭성 다형교모세포종은 발병 나이와 수술 후 중앙생존기간(median survival) 간에 유의한 차이를 보였다(p < 0.05). 결론: 낭성 다형교모세포종은 비낭성 다형교모세포종보다 주변 뇌조직과의 경계가 좋고, 종괴벽의 두께가 얇으며 상대적으로 적은 종괴주위 부종을 동반하였다. 또한, 낭성 다형교모세포종은 비낭성 다형교모세포종에 비해 어린 나이에 발병하며 수술 후 중앙생존기간(median survival)도 더 긴 것으로 나타났다.

Keywords

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