면역적합성 환자에서 비결핵 항산균 폐질환: 흉부 전산화단층촬영에서의 다양한 영상 소견

Nontuberculous Mycobacterial (NTM) Disease in Immunocompetent Patients: Expanding Image Findings on Chest CT

  • 신효현 (전남대학교병원 영상의학과) ;
  • 선현주 (전남대학교병원 영상의학과) ;
  • 김목희 (전남대학교병원 영상의학과) ;
  • 최송 (전남대학교병원 영상의학과) ;
  • 송상국 (전남대학교병원 영상의학과) ;
  • 신상수 (전남대학교병원 영상의학과) ;
  • 김윤현 (전남대학교병원 영상의학과) ;
  • 박진균 (전남대학교병원 영상의학과)
  • Shin, Hyo-Hyun (Department of Radiology, Chonnam National University, Medical School, Chonnam National University Hospital) ;
  • Seon, Hyun-Ju (Department of Radiology, Chonnam National University, Medical School, Chonnam National University Hospital) ;
  • Kim, Mok-Hee (Department of Radiology, Chonnam National University, Medical School, Chonnam National University Hospital) ;
  • Choi, Song (Department of Radiology, Chonnam National University, Medical School, Chonnam National University Hospital) ;
  • Song, Sang-Gook (Department of Radiology, Chonnam National University, Medical School, Chonnam National University Hospital) ;
  • Shin, Sang-Soo (Department of Radiology, Chonnam National University, Medical School, Chonnam National University Hospital) ;
  • Kim, Yun-Hyeon (Department of Radiology, Chonnam National University, Medical School, Chonnam National University Hospital) ;
  • Park, Jin-Gyoon (Department of Radiology, Chonnam National University, Medical School, Chonnam National University Hospital)
  • 투고 : 2010.02.02
  • 심사 : 2010.03.15
  • 발행 : 2010.08.01

초록

목적: 비결핵 항산균 폐질환의 흉부 전산화단층촬영에서의 영상 소견을 균주에 관계없이 알아 보고자 했다. 대상과 방법: 2005년 1월부터 2007년 7월까지 비결핵 항산균 폐질환으로 진단되고 흉부 전산화단층촬영을 시행한 74명(남:여 = 35:39)을 대상으로, 영상소견을 후향적으로 분석했다. 결과: 가장 흔한 균주는 M. avium-intracellulare complex (87.8%)이었고, 이외 M. abscessus, M. kansasii, 그리고 M. chelonae 가 있었다. 흉부 전산화단층촬영에서 주된 소견들은 결절성기관지확장증(46.7%), 상엽에 공동성 질환(28.0%), 그리고 두 소견의 병합(8.0%)이었다. 이 외에도 주로 경화성 병변 만을 보인 예, 주변의 위성 소결절과 동반된 공동성 종괴를 보인 예, 기관지 내 파급만을 보인 예 그리고 속립성 질환을 보인 예가 있었다. 81.1%에서 5분절 이상의 침범이 이었다. 결론: 다 분절을 침범하면서 결절성기관지확장증과 동반된 기관지주변 경화성 병변이 있거나 상엽의 파괴성 또는 비파괴성 공동성 병변이 있는 경우 비결핵 항산균 폐질환을 시사하는 소견이라 할 수 있다.

Purpose: The aim of this study was to evaluate the chest CT features of nontuberculous mycobacterial (NTM) disease regardless of the specific organisms. Materials and Methods: This study included 74 consecutive patients (35 men, 39 women; mean age, 63 years; age range, 25-89 years) who were diagnosed with NTM disease according to the American Thoracic Society Guidelines (1997 and 2007) between January 2005 and July 2007. Chest CT images were randomly reviewed by two radiologists with consensus. Results: The most common organism associated with NTM disease is M. avium-intracellulare complex (87.8%), followed by M. abscessus, M. kansasii, and M. chelonae. The most common chest CT finding was a nodular bronchiectatic lesion (n = 35, 46.7%), followed by a cavitary lesion of the upper lobe (n = 21, 28.0%), combined lesions of two prior subtypes (n = 6, 8.0%), consolidative lesion (s) (n = 5, 6.7%), a bronchogenic spreading pulmonary tuberculosis-like lesion (n = 5, 6.7%), a cavitary mass lesion with small satellite nodules (n = 2, 2.7%), and a miliary nodular lesion (n = 1, 1.3%). More than 5 segments were involved in 60 cases (81.1%). Conclusion: The nodular bronchiectatic lesion or cavitary lesion of upper lobe presents with multi-segmental involvement and the occurrence of combined consolidation is indicative of NTM disease.

키워드

참고문헌

  1. Diagnosis and treatment of disease caused by nontuberculous mycobacteria. This official statement of the American Thoracic Society was approved by the Board of Directors, March 1997. Medical Section of the American Lung Association. Am J Respir Crit Care Med 1997;156:S1-S25 https://doi.org/10.1164/ajrccm.156.2.atsstatement
  2. Management of opportunist mycobacterial infections: Joint tuberculosis committee guidelines 1999. Subcommittee of the joint tuberculosis committee of the british thoracic society. Thorax 2000;55:210-218 https://doi.org/10.1136/thorax.55.3.210
  3. Wolinsky E. Nontuberculous mycobacteria and associated diseases. Am Rev Respir Dis 1979;119:107-159
  4. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, et al. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007;175:367-416 https://doi.org/10.1164/rccm.200604-571ST
  5. Erasmus JJ, McAdams HP, Farrell MA, Patz EF Jr. Pulmonary nontuberculous mycobacterial infection: radiologic manifestations. Radiographics 1999;19:1487-1505
  6. Martinez S, McAdams HP, Batchu CS. The many faces of pulmonary nontuberculous mycobacterial infection. AJR Am J Roentgenol 2007;189:177-186 https://doi.org/10.2214/AJR.07.2074
  7. Ellis SM. The spectrum of tuberculosis and non-tuberculous mycobacterial infection. Eur J Radiol 2004;14 Suppl 3:E34-E42
  8. Koh WJ, Kwon OJ, Lee KS. Nontuberculous mycobacterial pulmonary diseases in immunocompetent patients. Korean J Radiol 2002;3:145-157 https://doi.org/10.3348/kjr.2002.3.3.145
  9. Kwon YS, Koh WJ, Chung MP, Kwon OJ, Lee NY, Cho EY, et al. Solitary pulmonary nodule due to Mycobacterium intracellulare: the first case in Korea. Yonsei Med J 2007;48:127-130 https://doi.org/10.3349/ymj.2007.48.1.127
  10. Bai GH, Park KS, Kim SJ. Clinically isolated mycobacteria other than Mycobacterium tuberculosis from 1980 to 1990 in Korea. J Korean Soc Microbiol 1993;28:1-5
  11. Yoon CJ, Goo JM, Seo JB, Kim SH, Im JG. CT findings of mycobacterial infection other than tuberculosis: comparison with tuberculosis. J Korean Radiol Soc 2000;42:487-492 https://doi.org/10.3348/jkrs.2000.42.3.487
  12. Lew WJ, Ahh DI, Yoon YJ, Cho JS, Kwon DW, Kim SJ, et al. Clinical experience of mycobacterial disease other than tuberculosis. Tuberc Respir Dis 1992;39:425-432
  13. Christensen EE, Dietz GW, Ahn CH, Champman JS, Murry RC, Adnerson J, et al. Initial roentgenographic manifestations of pulmonary Mycobacterium tuberculosis, M kansasii, and M intracellularis infections. Chest 1981;80:132-136 https://doi.org/10.1378/chest.80.2.132
  14. Koh WJ, Lee KS, Kwon OJ, Jeong YJ, Kwak SH, Kim TS. Bilateral bronchiectasis and bronchiolitis at thin-section CT: diagnostic implications in nontuberculous mycobacterial pulmonary infection. Radiology 2005;235:282-288 https://doi.org/10.1148/radiol.2351040371
  15. Chung MJ, Lee KS, Koh WJ, Lee JH, Kim TS, Kwon OJ, et al. Thinsection CT findings of nontuberculous mycobacterial pulmonary diseases: comparison between Mycobacterium avium-intracellulare complex and Mycobacterium abscessus infection. J Korean Med Sci 2005;20:777-783 https://doi.org/10.3346/jkms.2005.20.5.777