Metastatic Large Cell Neuroendocrine Carcinoma Combined with Gastric Adenocarcinoma

조기 위샘암종의 부위 림프절에서 발견된 전이성 대세포 신경내분비암종

  • Cho, Kun-Hyung (Department of Internal Medicine, College of Medicine, Kyung Hee University) ;
  • Chang, Young-Woon (Department of Internal Medicine, College of Medicine, Kyung Hee University) ;
  • Sohn, Seong-Dong (Department of Internal Medicine, College of Medicine, Kyung Hee University) ;
  • HwangBo, Young (Department of Internal Medicine, College of Medicine, Kyung Hee University) ;
  • Shim, Jae-Jun (Department of Internal Medicine, College of Medicine, Kyung Hee University) ;
  • Jang, Jae-Young (Department of Internal Medicine, College of Medicine, Kyung Hee University) ;
  • Kim, Hyo-Jong (Department of Internal Medicine, College of Medicine, Kyung Hee University) ;
  • Kim, Byung-Ho (Department of Internal Medicine, College of Medicine, Kyung Hee University)
  • 조근형 (경희대학교 의과대학 내과학교실) ;
  • 장영운 (경희대학교 의과대학 내과학교실) ;
  • 손성동 (경희대학교 의과대학 내과학교실) ;
  • 황보영 (경희대학교 의과대학 내과학교실) ;
  • 심재준 (경희대학교 의과대학 내과학교실) ;
  • 장재영 (경희대학교 의과대학 내과학교실) ;
  • 김효종 (경희대학교 의과대학 내과학교실) ;
  • 김병호 (경희대학교 의과대학 내과학교실)
  • Received : 2010.01.21
  • Accepted : 2010.06.11
  • Published : 2010.08.30

Abstract

A 67 year-old man was admitted due to findings that were suspicious for malignancy on gastroscopy at a primary clinic. We also performed gastroscopy and this showed the presence of a 3 cm sized nodular elevated lesion at the angle of the stomach. A biopsy demonstrated the presence of adenocarcinoma of the stomach. A distal gastrectomy with D2 lymph node dissection was performed and the microscopic features of the resected specimen confirmed the diagnosis of adenocarcinoma of the stomach and also metastatic large cell neuroendocrine carcinoma of lymph nodes of an unknown primary origin. Although double primary gastric adenocarcinoma and gastric neuroendocrine tumor with regional lymph node metastasis has been seldom reported, a double primary carcinoma of gastric adenocarcinoma and metastatic large cell neuroendocrine carcinoma of lymph nodes has seldom been reported. We report on this unusual case along with a review of the relevant medical literature.

67세 남자가 건강 검진 상부위장관 내시경에서 이상 소견으로 내원하였다. 내시경 조직검사에서 위각부의 샘암종을 진단하였고 복부 전산화 단층촬영과 전신 양전자방출 단층촬영에서 위 부위림프절 전이가 의심되어 위 원위부절제술 및 D2 림프절 절제술을 시행하였다. 절제된 위에서 샘암종을 확진하였으며 림프절에서 원발 미상의 전이성 대세포 신경내분비암종을 진단하여 중복 암종으로 최종 진단하였다. 위에서 샘암종과 신경내분비암종이 혼재된 증례는 보고된 바 있으나 위와 위 부위림프절에서 각각 중복 암종으로 샘암종과 신경내분비암종이 진단된 증례는 드물기에 고찰과 함께 보고한다.

Keywords

References

  1. Capella C, Heitz PU, Hofler H, Solcia E, Kloppel G. Revised classification of neuroendocrine tumours of the lung, pancreas and gut. Virchows Arch 1995;425:547-560.
  2. Pidoto RR, Piquard A, Fama F, Saint Marc O. Lymph node metastasis from gastric carcinoid tumors occurring concomitantly with gastric adenocarcinomas and atrophic gastritis. J Gastrointest Surg 2006;10:402-406. https://doi.org/10.1016/j.gassur.2005.07.014
  3. Ronellenfitsch U, Strobel P, Schwarzbach MH, Staiger WI, Gragert D, Kahler G. A composite adenoendocrine carcinoma of the stomach arising from a neuroendocrine tumor. J Gastrointest Surg 2007;11:1573-1575. https://doi.org/10.1007/s11605-007-0172-5
  4. Jung JH, Kim YC, Kim JH, et al. A case of a gastric composite tumor with an adenocarcinoma and a large cell neuroendocrine carcinoma. Korean J Gastrointest Endosc 2009;39:93-96.
  5. Kloppel G. Tumour biology and histopathology of neuroendocrine tumours. Best Pract Res Clin Endocrinol Metab 2007;21:15-31. https://doi.org/10.1016/j.beem.2007.01.004
  6. Yao JC, Hassan M, Phan A, et al. One hundred years after "carcinoid": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J Clin Oncol 2008;26:3063-3072. https://doi.org/10.1200/JCO.2007.15.4377
  7. Oien KA. Pathologic evaluation of unknown primary cancer. Semin Oncol 2009;36:8-37. https://doi.org/10.1053/j.seminoncol.2008.10.009
  8. Hainsworth JD, Johnson DH, Greco FA. Poorly differentiated neuroendocrine carcinoma of unknown primary site. A newly recognized clinicopathologic entity. Ann Intern Med 1988; 109:364-371. https://doi.org/10.7326/0003-4819-109-5-364
  9. Moertel CG, Kvols LK, O'Connell MJ, Rubin J. Treatment of neuroendocrine carcinomas with combined etoposide and cisplatin. Evidence of major therapeutic activity in the anaplastic variants of these neoplasm. Cancer 1991;68:227-232. https://doi.org/10.1002/1097-0142(19910715)68:2<227::AID-CNCR2820680202>3.0.CO;2-I
  10. Hainsworth JD, Spigel DR, Litchy S, Greco FA. Phase II trial of paciltaxel, carboplatin and etoposide in advanced poorly differentiated neuroendocrine carcinoma: a minnie pearl cancer research network study. J Clin Oncol 2006;24:3548-3554. https://doi.org/10.1200/JCO.2005.05.0575