Clinical Endoscopy

The Korean Society of Gastrointestinal Endoscopy (대한소화기내시경학회)
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Two Cases of Eosinophilic Esophagitis Treated with a Proton Pump Inhibitor and a Systemic Steroid

양성자 펌프 억제제와 전신 스테로이드로 치료한 호산구 식도염 2예

  • Lee, Jeong-Rok (Department of Internal Medicine, Cheju Halla General Hospital) ;
  • Song, Kyung-Ho (Department of Internal Medicine, Cheju Halla General Hospital) ;
  • Jeon, Won-Joong (Department of Internal Medicine, Cheju Halla General Hospital) ;
  • Lee, Sang-Jin (Department of Internal Medicine, Cheju Halla General Hospital) ;
  • Cha, Byung-Hyo (Department of Internal Medicine, Cheju Halla General Hospital) ;
  • Kim, Jin-Dong (Department of Internal Medicine, Cheju Halla General Hospital) ;
  • Kim, Young-Nam (Department of Internal Medicine, Cheju Halla General Hospital) ;
  • Ha, Chang-Won (Department of Pathology, Cheju Halla General Hospital)
  • Received : 2010.04.15
  • Accepted : 2010.07.04
  • Published : 2010.08.30
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Abstract

Eosinophilic esophagitis is a chronic inflammatory disorder characterized by dense eosinophilic infiltration of the esophageal mucosa. As an emerging disease during the last decade, eosinophilic esophagitis has gained increased recognition in both the medical and research communities. The pathogenesis is incompletely understood and food allergies and aeroallergens have been implicated. The most common clinical symptoms in adults are dysphagia and food impaction. We diagnosed two cases as eosinophilic esophagitis and treated them with a proton pump inhibitor and a systemic steroid. We confirmed improvements in clinical presentation and histologic findings and report these cases.

호산구 식도염은 식도 점막에 호산구 침착을 특징으로 하는 만성 염증성 질환이다. 이 질환의 병인론은 명확하지는 않지만 많은 문헌에서 알레르기 항원이 관여되어 있을 것으로 여겨진다. 일반적으로 식도 점막 생검에서 호산구의 침착이 고배율 시야에서 15개 이상 관찰되었을 때 진단될 수 있다. 저자들은 삼킴곤란과 흉통을 주소로 내원하여 상부위장관 내시경검사에서 동심원 모양의 주름, 종축 방향의 골을 관찰하였으며 식도 조직 검사에서 호산구 식도염을 진단하고 각각 고용량 양성자 펌프 억제제 투여와 전신 스테로이드로 치료하여 증상 및 조직학적 호전을 확인하였으며, 6개월 이상 추적 관찰 동안 재발을 하지 않은 증례를 문헌 고찰과 함께 보고한다.

Keywords

References

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