The Korean journal of internal medicine

The Korean Association of Internal Medicine (대한내과학회)
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Association of the Superoxide Dismutase (V16A) and Catalase (C262T) Genetic Polymorphisms with the Clinical Outcome of Patients with Acute Paraquat Intoxication

  • Hong, Joong-Rock (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Seok, Su-Jin (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Jeong, Du-Shin (Department of Neurology & Epidemiology Biostatistics, Soonchunhyang University College of Medicine) ;
  • Lee, Sang-Gon (Department of Laboratory Medicine, Green Cross Reference Laboratory) ;
  • Gil, Hyo-Wook (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Yang, Jong-Oh (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Lee, Eun-Young (Department of Internal Medicine, Soonchunhyang University College of Medicine) ;
  • Hong, Sae-Yong (Department of Internal Medicine, Soonchunhyang University College of Medicine)
  • Received : 2010.03.01
  • Accepted : 2010.04.16
  • Published : 2010.12.01
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Abstract

Background/Aims: Many patients with acute paraquat (PQ) intoxication die even at low PQ concentrations, whereas others with similar concentrations recover. Therefore, it is possible that individual differences in antioxidant capacity are responsible for the variable clinical outcome in patients with acute PQ intoxication. Methods: We investigated whether there was a relationship between the genetic polymorphisms of SOD (V16A), catalase (C262T), and GPX1 (C593T) in 62 patients with acute PQ intoxication and the clinical outcomes of these patients. Results: The frequency of the Mn-SOD V/V, V/A, and A/A genotypes were 56.3, 43.5, and 0% in survivors and 86.9, 13.1, and 0% in non-survivors (p > 0.05). The GPX1 C/C, C/T, and T/T genotypes were present in 100, 0, and 0% of all subjects. The catalase C/C, C/T, and T/T genotypes were present in 100, 0, and 0% of survivors, and in 82.6, 17.4, and 0% of non-survivors. Neither erythrocyte SOD activity nor catalase activity were significantly different between survivors and non-survivors. Conclusions: No association was found between clinical outcome of acute PQ intoxication and the genetic polymorphism of GPX1 (C593T) or the genetic polymorphisms or enzyme activity of superoxide dismutase (V16A) or catalase (C262T).

Keywords

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