DOI QR코드

DOI QR Code

A Case of Systemic Lupus Erythematosus Presenting as Malignant Hypertension with Hypertensive Retinopathy

  • Choe, Jung-Yoon (Department of Internal Medicine, Catholic University of Daegu School of Medicine) ;
  • Park, Sung-Hoon (Department of Internal Medicine, Catholic University of Daegu School of Medicine) ;
  • Kim, Ji-Young (Department of Internal Medicine, Catholic University of Daegu School of Medicine) ;
  • Jung, Hyun-Young (Department of Internal Medicine, Catholic University of Daegu School of Medicine) ;
  • Kim, Seong-Kyu (Department of Internal Medicine, Catholic University of Daegu School of Medicine)
  • Received : 2007.08.31
  • Accepted : 2007.12.03
  • Published : 2010.09.01

Abstract

The variability of cardiovascular abnormalities is one of the characteristics of systemic lupus erythematosus (SLE). Among the cardiovascular manifestations, hypertension is reported in 14% to 58.1% of patients in diverse ethnic populations, and remains a clinically important issue due to its close relationship with early mortality in patients with SLE. The development of hypertension in patients with SLE has been associated with advanced lupus-related renal disease and the medications used for the treatment of lupus. Malignant hypertension is a serious complication of hypertension; it rarely occurs in patients with SLE. However, it can occur in patients with other complicated medical conditions such as the antiphospholipid antibody syndrome (APS) or cardiac tamponade. Here, we report the case of a patient with SLE and malignant hypertension with hypertensive retinopathy that initially presented without clinical evidence of APS or hypertensive nephropathy.

Keywords

References

  1. Ruiz-Irastorza G, Khamashta MA, Castellino G, Hughes GR. Systemic lupus erythematosus. Lancet 2001;357:1027-1032. https://doi.org/10.1016/S0140-6736(00)04239-2
  2. Keith NM, Wagner HP, Kernohan JW. The syndrome of malignant hypertension. Arch Intern Med 1928;41:141-188. https://doi.org/10.1001/archinte.1928.00130140003001
  3. Yu SH, Whitworth JA, Kincaid-Smith PS. Malignant hypertension: aetiology and outcome in 83 patients. Clin Exp Hypertens A 1986;8:1211-1230.
  4. Jouquan J, Pennec Y, Mottier D, et al. Accelerated hypertension associated with lupus anticoagulant and false-positive VDRL in systemic lupus erythematosus. Arthritis Rheum 1986;29:147. https://doi.org/10.1002/art.1780290121
  5. Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25:1271-1277. https://doi.org/10.1002/art.1780251101
  6. Shibagaki Y, Fujita T. Thrombotic microangiopathy in malignant hypertension and hemolytic uremic syndrome (HUS)/ thrombotic thrombocytopenic purpura (TTP): can we differentiate one from the other? Hypertens Res 2005;28:89-95. https://doi.org/10.1291/hypres.28.89
  7. Budman DR, Steinberg AD. Hypertension and renal disease in systemic lupus erythematosus. Arch Intern Med 1976;136:1003-1007. https://doi.org/10.1001/archinte.136.9.1003
  8. Kaplan D, Ginzler EM, Feldman J. Arthritis and hypertension in patients with systemic lupus erythematosus. Arthritis Rheum 1992;35:423-428. https://doi.org/10.1002/art.1780350411
  9. Uthman I, Khamashta M. Antiphospholipid syndrome and the kidneys. Semin Arthritis Rheum 2006;35:360-367. https://doi.org/10.1016/j.semarthrit.2006.01.001
  10. Giorgi D, Pace F, Giorgi A, Bonomo L, Gabrieli CB. Retinopathy in systemic lupus erythematosus: pathogenesis and approach to therapy. Hum Immunol 1999;60:688-696. https://doi.org/10.1016/S0198-8859(99)00035-X

Cited by

  1. Hypertensive Retinopathy as the First Manifestation of Advanced Renal Disease in a Young Patient: Report of a Case vol.6, pp.3, 2010, https://doi.org/10.1159/000442660