DOI QR코드

DOI QR Code

Primary Pulmonary Biphasic Synovial Sarcoma Confirmed by Molecular Detection of a SYT-SSX2 Fusion Gene: Report of 1 Case

  • Park, Jae-Seok (Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine) ;
  • Min, Bo-Ram (Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine) ;
  • Park, Soon-Hyo (Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine) ;
  • Kwon, Kun-Young (Department of Pathology, Dongsan Medical Center, Keimyung University School of Medicine) ;
  • Keum, Dong-Yoon (Department of Thoracic Surgery, Dongsan Medical Center, Keimyung University School of Medicine) ;
  • Choi, Won-Il (Department of Internal Medicine, Dongsan Medical Center, Keimyung University School of Medicine)
  • Received : 2007.12.28
  • Accepted : 2008.05.13
  • Published : 2010.09.01

Abstract

We experienced a case of primary pulmonary biphasic synovial sarcoma, which was confirmed by immunohistochemistry and molecular testing of SYT-SSX2 fusion transcripts. The patient was a 61-year-old man who presented with a well-defined mass in the left upper lung field on chest radiography. Left upper lobectomy with lymph node dissection was performed. Histological and immunophenotypic features were consistent with biphasic synovial sarcoma. Reverse transcriptase polymerase chain reaction, performed using RNA extracted from frozen tumor samples for the detection of SYT-SSX fusion gene, amplified a single 331-bp fragment that was characteristic of the SYT-SSX2 fusion transcripts. We report a case of primary pulmonary biphasic synovial sarcoma, which was confirmed by SYT-SSX2 fusion transcripts, and present a brief review of the literature on Korean cases.

Keywords

References

  1. Hosono T, Hironaka M, Kobayashi A, et al. Primary pulmonary synovial sarcoma confirmed by molecular detection of SYT-SSX1 fusion gene transcripts: a case report and review of the literature. Jpn J Clin Oncol 2005;35:274-279. https://doi.org/10.1093/jjco/hyi073
  2. Kawai A, Woodruff J, Healey JH, Brennan MF, Antonescu CR, Ladanyi M. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. N Engl J Med 1998;338:153-160. https://doi.org/10.1056/NEJM199801153380303
  3. Coindre JM, Pelmus M, Hostein I, Lussan C, Bui BN, Guillou L. Should molecular testing be required for diagnosing synovial sarcoma? A prospective study of 204 cases. Cancer 2003;98: 2700-2707. https://doi.org/10.1002/cncr.11840
  4. Begueret H, Galateau-Salle F, Guillou L, et al. Primary intrathoracic synovial sarcoma: a clinicopathologic study of 40 t(X;18)-positive cases from the French Sarcoma Group and the Mesopath Group. Am J Surg Pathol 2005;29:339-346. https://doi.org/10.1097/01.pas.0000147401.95391.9a
  5. Ladanyi M, Antonescu CR, Leung DH, et al. Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multiinstitutional retrospective study of 243 patients. Cancer Res 2002;62:135-140.
  6. Guillou L, Benhattar J, Bonichon F, et al. Histologic grade, but not SYT-SSX fusion type, is an important prognostic factor in patients with synovial sarcoma: a multicenter, retrospective analysis. J Clin Oncol 2004;22:4040-4050. https://doi.org/10.1200/JCO.2004.11.093
  7. Lee EA, Lee DY, Kwag HJ, et al. A case of monophasic fibrous synovial sarcoma confirmed primary pulmonary origin by 18FFDG PET/CT. Tuberc Respir Dis 2006;60:673-677. https://doi.org/10.4046/trd.2006.60.6.673
  8. Shin SH, Song DS, Jung WS, et al. Primary pulmonary synovial sarcoma with brain metastasis. Korean J Thorac Cardiovasc Surg 2000;33:329-332.
  9. Song SH, Lee KH, Oh JH, et al. A case of primary pulmonary sarcoma with morphologic features of biphasic synovial sarcoma. Tuberc Respir Dis 1998;45:1284-1289.
  10. Yoon GS, Park SY, Kang GH, Kim OJ. Primary pulmonary sarcoma with morphologic features of biphasic synovial sarcoma: a case report. J Korean Med Sci 1998;13:71-76.
  11. Kim MH, Kim KT, Kim HJ. Primary pulmonary synovial sarcoma: a case report. Korean J Thorac Cardiovasc Surg 1997;30:1259-1261.
  12. Shin JS, Hwang JJ, Choi YH, Kim HJ. Intrapulmonary synovial sarcoma: a case report. Korean J Thorac Cardiovasc Surg 1993;26:726-729.

Cited by

  1. Characterization of synovial sarcoma calcification. vol.199, pp.6, 2010, https://doi.org/10.2214/ajr.11.7342
  2. 종격동 내 발생한 활막 육종 1예 vol.30, pp.1, 2010, https://doi.org/10.12701/yujm.2013.30.1.51
  3. Primary Pulmonary Synovial Sarcoma in a Tertiary Referral Center: Clinical Characteristics, CT, and 18 F-FDG PET Findings, With Pathologic Correlations vol.94, pp.34, 2010, https://doi.org/10.1097/md.0000000000001392