The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Clevudine induced diabetes mellitus in a patient with chronic hepatitis B

만성 B형 간염 환자에서 클레부딘 복용 후 발병된 당뇨병 1예

  • Kim, Gun-Woo (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Lee, Mi-Young (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Kim, Song-Yi (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Kim, Jae-Hyun (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Lee, Jin-Hyung (Department of Internal Medicine, Yonsei University Wonju College of Medicine) ;
  • Chung, Choon-Hee (Department of Internal Medicine, Yonsei University Wonju College of Medicine)
  • 김건우 (연세대학교 의과대학 원주기독병원 내과학교실) ;
  • 이미영 (연세대학교 의과대학 원주기독병원 내과학교실) ;
  • 김송이 (연세대학교 의과대학 원주기독병원 내과학교실) ;
  • 김재현 (연세대학교 의과대학 원주기독병원 내과학교실) ;
  • 이진형 (연세대학교 의과대학 원주기독병원 내과학교실) ;
  • 정춘희 (연세대학교 의과대학 원주기독병원 내과학교실)
  • Received : 2009.10.16
  • Accepted : 2009.11.05
  • Published : 2010.11.01
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Abstract

Several studies have documented that various agents can induce diabetes mellitus, such as steroids, thiazides, anti-psychotic agents, and anti-viral agents. Many antiviral agents are also reported to impair insulin resistance and induce diabetes mellitus in patients infected with human immunodeficiency virus (HIV). However, there are no reports of diabetes mellitus induced by clevudine, one of the antiviral agents used to treat chronic hepatitis B virus (HBV) infection. We report a case of diabetes mellitus induced by clevudine in a patient with chronic hepatitis B.

저자들은 만성 B형 간염 환자에서 항바이러스제제인 clevudine을 사용 후 유발된 당뇨병을 경험하였기에 보고하는 바이다. Clevudine의 혈당 상승 부작용에 대한 연구는 아직 많지 않아 그 기전에 대해서 앞으로 연구가 필요할 것으로 생각된다.

Keywords

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