The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
권호 표지

Recent update on pathogenesis of nonalcoholic fatty liver disease

비알코올성 지방간질환의 발병기전에 대한 최신지견

  • Sohn, Joo-Hyun (Department of Internal Medicine, Hanyang University College of Medicine) ;
  • Kim, Tae-Yeob (Department of Internal Medicine, Hanyang University College of Medicine)
  • 손주현 (한양대학교 의과대학 내과학교실) ;
  • 김태엽 (한양대학교 의과대학 내과학교실)
  • Published : 2010.11.01
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Abstract

Recently, the prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in Korean population. NAFLD includes a spectrum of hepatic pathology from simple steatosis in its most benign form, to nonalcoholic steatohepatitis (NASH) and/or cirrhosis. NAFLD has a strong association with type 2 diabetes and obesity, and thus it is now recognized to represent the hepatic manifestation of metabolic syndrome. The pathogenesis of simple steatosis occurrence and its progression to NASH is not entirely elucidated and multi-factorial. Liver fat accumulation is mainly induced by insulin resistance and increased free fatty acids, and then NASH is developed by oxidative stress, lipid peroxidation, mitochondrial dysfunction, gut-derived endotoxin, and cytokine/adipokine interplay. Genetic factors and environmental factors such as exercise and high fat and high fructose diet also participate in the development of NAFLD. This review is focused to summarize the up-to-date understanding of NAFLD pathogenesis.

Keywords

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