The Korean Journal of Medicine

The Korean Association of Internal Medicine (대한내과학회)
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Nonventilatory medical treatments for acute respiratory distress syndrome and acute lung injury

급성 폐손상과 급성 호흡곤란 증후군의 내과적 치료

  • Sohn, Jang-Won (Department of Internal Medicine, Hanyang University College of Medicine)
  • 손장원 (한양대학교 의과대학 내과학교실)
  • Published : 2010.07.01
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Abstract

Over the past decade, the ventilator management for acute respiratory distress syndrome (ARDS) and acute lung injury (ALI) have yielded improved outcomes. However, studies of the pharmacologic management of ARDS and ALI have been less effective. ARDS/ALI is a heterogeneous disease entity. Although most drug trials in ARDS or ALI have been demonstrated to be ineffective in improving outcomes, some studies suggest that targeting treatments at subgroups of patients may be beneficial. Corticosteroids have good short-term effects when given sooner than 2 weeks. Surfactant may be beneficial in direct lung injury patients. Anticoagulants may have improved outcomes in the severe patients with vascular disease. Recently, ARDS Networks reported the 'conservative fluid management strategy'. This promising fluid strategy showed beneficial effect on outcomes without serious complications. This article reviews the recent research on the Nonventilatory pharmacologic managements for patients with ARDS/ALI.

Keywords

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