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A Novel 3-Phenylethynyl-2-yl-oxy Quinoxaline Core Skeleton and Pharmacophore Model as a Hypoxia-inducible Factor Inhibitor

  • Gong, Young-Dae (Innovative Drug Library Research Center, Department of Chemistry, Dongguk University-Seoul) ;
  • Kang, Nam-Sook (Drug Discovery Platform Technology Team, Korea Research Institute of Chemical Technology)
  • Received : 2010.07.22
  • Accepted : 2010.09.13
  • Published : 2010.11.20

Abstract

Keywords

References

  1. Semenza, G. L. Drug Discov. Today 2007, 12, 853. https://doi.org/10.1016/j.drudis.2007.08.006
  2. Jiang, B. H.; Rue, E.; Wang, G. L.; Roe, R. J.; Semenza. G. L. J. Biol. Chem. 1996, 271, 17771. https://doi.org/10.1074/jbc.271.30.17771
  3. Wang, G. L.; Semenza, G. L. J. Biol. Chem. 1995, 270, 1230. https://doi.org/10.1074/jbc.270.3.1230
  4. Kaelin, W. G. Annu. Rev. Biochem. 2005, 74, 115. https://doi.org/10.1146/annurev.biochem.74.082803.133142
  5. Lee, K.; Lee, J. H.; Boovanahalil, S. K.; Jin, Y.; Lee, M.; Jin, X.; Kim, J. H.; Hong, Y.-S.; Lee, J. J. J. Med. Chem. 2007, 50, 1675. https://doi.org/10.1021/jm0610292
  6. Giaccia, A.; Siim, B. G.; Johnson, R. S. Nat. Rev. Drug Discovery 2003, 2, 1. https://doi.org/10.1038/nrd992
  7. Choi, H. J.; Song, B.-J.; Gong, Y.-D.; Gwak, W. J.; Soh, Y. British J. Pharm. 2008, 154, 114. https://doi.org/10.1038/bjp.2008.70
  8. Chalet, T.; Rita, G. N.; Anthony, J. R.; Beata, P.; Fatima, K.; Zhaobin, Z.; Huanchun, Z.; Quincy, T.; Ainsley, C. N.; Paraskevi, G.; Wei, Z.; Jeffrey, J. O.; Manuela, M. P.; Nicolaou, K. C.; Erwin, G. V. M. Cancer Res. 2005, 65, 605.
  9. Jeon, M.-K.; Kim, D.-S.; La, H. J.; Gong, Y.-D. Tetrahedron Lett. 2005, 46, 4979. https://doi.org/10.1016/j.tetlet.2005.05.096
  10. Gong, Y.-D.; Jeon, M.-K.; Hwang, S. H.; Dong, M. S.; Lee, S. B.; Kang, K. H.; Oh, C. H. Kor. Pat. 0889389, 2009.
  11. Gong, Y.-D.; Jeon, M.-K.; Hwang, Lee, Th.; Hwang, S. H.; Yoo, S.-e. Kor. Pat. Appl. 2008-0016257, 2008.
  12. Amar, G. C.; Gundluru, M. K.; Kumar, P. B. C.; Yang, L.; Yu-Dong, Z.; Dale, G. N.; Mitchell A. A. J. Med. Chem. 2007, 50, 6299. https://doi.org/10.1021/jm7011062
  13. Park, J. W.; Chun, Y. S.; Kenneth, B.; Sho, H. S. WO 2005030121. 2005.
  14. Warshakoon, N. C.; Wu, S.; Boyer, A.; Kawamoto, R.; Renock, S.; Xu, K.; Pokross, M.; Evdokimov, A. G.; Zhou, S.; Winter, C.; Walter, R.; Mekel, M. Bioorg. Med. Chem. Lett. 2006, 16, 5687. https://doi.org/10.1016/j.bmcl.2006.08.017
  15. Ventosa-Andres, P.; Gonzalez-Vera, J. A.; Valdivielso, A. M.; Teresa Garcia-Lopez, M.; Herranz, R. Bioorg. Med. Chem. 2008, 16, 9313. https://doi.org/10.1016/j.bmc.2008.08.070
  16. Concord; Tripos Inc., 1699 South Hanley Road, St. Louis, MO 63144.
  17. Sprague, P. W. Automated Chemical Hypothesis Generation and Database Searching with Catalyst. In Perspectives in Drug Discovery and Design; Muller, K., Ed.; ESCOM Science Publishers B. V.: Leiden, The Netherlands, 1995; Vol. 3, pp 1-20.
  18. Gong, Y.-D.; Kang, N. S. Bull. Korean Chem. Soc. 2010, 31, 2039. https://doi.org/10.5012/bkcs.2010.31.7.2039
  19. Hert, J.; Willett, P.; Wilton, D. J.; Acklin, P.; Azzaoui, K.; Jacoby, E.; Schuffenhauer, A. J. Chem. Inf. Comp. Sci. 2004, 44, 1177. https://doi.org/10.1021/ci034231b
  20. Han, Z. B.; Ren, H.; Zhao, H.; Chi, Y.; Chen, K.; Zhou, B.; Liu, Y. J.; Zhang, L.; Xu, B.; Liu, B.; Yang, R.; Han, Z. C. Carcinogenesis 2008, 29, 1853. https://doi.org/10.1093/carcin/bgn066

Cited by

  1. ChemInform Abstract: A Novel 3-Phenylethynyl-2-yl-oxy Quinoxaline Core Skeleton and Pharmacophore Model as a Hypoxia-Inducible Factor Inhibitor. vol.42, pp.12, 2011, https://doi.org/10.1002/chin.201112168