Bulletin of the Korean Chemical Society

  • 제31권11호
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  • Pages.3348-3352
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  • 2010
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and Anti-HIV Activity of Novel 4'-Ethyl-5'-norcarbocyclic Adenosine Phosphonic Acid Analogues

  • Yoo, Jin-Cheol (BK-21 Project Team, College of Pharmacy, Chosun University) ;
  • Li, Hua (BK-21 Project Team, College of Pharmacy, Chosun University) ;
  • Lee, Won-Jae (BK-21 Project Team, College of Pharmacy, Chosun University) ;
  • Hong, Joon-Hee (BK-21 Project Team, College of Pharmacy, Chosun University)
  • 투고 : 2010.07.20
  • 심사 : 2010.09.15
  • 발행 : 2010.11.20
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초록

Novel 4'-ethyl-5'-norcarbocyclic adenosine phosphonic acid analogues were synthesized from propionaldehyde 5 through a de novo acyclic synthetic route using reiterative Grignard additions and ring-closing metathesis (RCM) as key reactions. The synthesized nucleoside phosphonic acids analogues 17, 18, 19, and 21 were subjected to antiviral screening against human immunodeficiency virus.

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참고문헌

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피인용 문헌

  1. ChemInform Abstract: Synthesis and anti-HIV Activity of Novel 4′-Ethyl-5′-norcarbocyclic Adenosine Phosphonic Acid Analogues. vol.42, pp.13, 2011, https://doi.org/10.1002/chin.201113208
  2. 5′-Norcarbocyclic nucleoside analogs vol.63, pp.5, 2014, https://doi.org/10.1007/s11172-014-0551-5
  3. The chemistry of the carbon–transition metal double and triple bond: Annual survey covering the year 2010 vol.256, pp.13, 2010, https://doi.org/10.1016/j.ccr.2012.02.015