Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Electrochemical Determination of Dopamine Based on Carbon Nanotube-Sol-Gel Titania-Nafion Composite Film Modified Electrode

  • Park, Ji-Ae (Department of Chemistry and Center for Bioactive Molecular Hybrids, Yonsei University) ;
  • Kim, Byung-Kun (Department of Chemistry and Center for Bioactive Molecular Hybrids, Yonsei University) ;
  • Choi, Han-Nim (Department of Chemistry and Center for Bioactive Molecular Hybrids, Yonsei University) ;
  • Lee, Won-Yong (Department of Chemistry and Center for Bioactive Molecular Hybrids, Yonsei University)
  • Received : 2010.08.09
  • Accepted : 2010.09.08
  • Published : 2010.11.20
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Abstract

A highly sensitive electrochemical detection method for dopamine (DA) has been developed by relying on a multiwalled carbon nanotube (CNT)-sol-gel titania-Nafion composite film modified glassy carbon (GC) electrode. The CNT-titania-Nafion/GC electrode exhibited excellent electrocatalytic activity towards DA. Therefore, the CNT-titania-Nafion/GC electrode showed improved voltammetric and amperometric responses for DA compared to those obtained with both titania-Nafion/GC and Nafion/GC electrodes. The CNT-titania-Nafion/GC electrode gave a linear response ($R^2$ = 0.999) for DA from $0.5\;{\mu}M$ to 0.5 mM with a detection limit (S/N = 3) of $0.1\;{\mu}M$ and a good sensitivity of 150 mA/M while other electrodes such as CNT-Nafion/GC, titania-Nafion/GC, and a bare GC gave a sensitivity of 89, 39, and 36 mA/M, respectively. Besides, the CNT-titania-Nafion/GC electrode displayed very fast response time within 2 s. The modified electrode showed good selectivity against ascorbic acid. The modified electrode showed good stability and reproducibility. The CNT-titania-Nafion/GC electrode was applied to the determination of DA in urine and serum samples.

Keywords

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