Progress in Medical Physics (한국의학물리학회지:의학물리)

Korean Society of Medical Physics (한국의학물리학회)
권호 표지

Comparison of Radioactivity Measurement with Radionuclide Calibrators in Nuclear Medicine Centers

의료용 방사능측정기의 측정 정확도 평가

  • Son, Hye-Kyung (Radiation Safety Division, National Institute of Food and Drug Safety Evaluation) ;
  • Kim, Ji-Hye (Radiation Safety Division, National Institute of Food and Drug Safety Evaluation) ;
  • Lim, Chun-Il (Radiation Safety Division, National Institute of Food and Drug Safety Evaluation) ;
  • Yang, Hyun-Kyu (Radiation Safety Division, National Institute of Food and Drug Safety Evaluation) ;
  • Park, Ki-Jung (Fusion Technology Medical Devices Team, National Institute of Food and Drug Safety Evaluation) ;
  • Oh, Heon-Jin (Medical Device Research Division, National Institute of Food and Drug Safety Evaluation) ;
  • Kim, Hyeog-Ju (Radiation Safety Division, National Institute of Food and Drug Safety Evaluation) ;
  • Kim, Dong-Sup (Pharmaceuticals and Medical Devices Research Department, National Institute of Food and Drug Safety Evaluation)
  • 손혜경 (식품의약품안전평가원 방사선안전과) ;
  • 김지혜 (식품의약품안전평가원 방사선안전과) ;
  • 임천일 (식품의약품안전평가원 방사선안전과) ;
  • 양현규 (식품의약품안전평가원 방사선안전과) ;
  • 박기정 (식품의약품안전평가원 융합기기팀) ;
  • 오헌진 (식품의약품안전평가원 의료기기연구과) ;
  • 김혁주 (식품의약품안전평가원 방사선안전과) ;
  • 김동섭 (식품의약품안전평가원 의료제품연구부)
  • Received : 2009.11.09
  • Accepted : 2010.03.02
  • Published : 2010.03.31
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Abstract

To acquire good image quality and to minimize unnecessary radiation dose to patients, it is important to ensure that the radiopharmaceutical administered is accurately measured. Quality control of radionuclide calibrators should be performed to achieve these goals. The purpose of this study is to support the quality control of radionuclide calibrators in nuclear medicine centers and to investigate the level of measurement accuracy of the radionuclide calibrators. 58 radionuclide calibrators from 45 nuclear medicine centers, 74 radionuclide calibrators from 58 nuclear medicine centers, and 60 radionuclide calibrators from 45 nuclear medicine centers were tested with I-131, Tc-99m and I-123, respectively. The results showed that 81% of calibrators for I-131, 61% of calibrators for Tc-99m and 67% of calibrators for I-123 were within ${\pm}5%$. 17% of calibrators for I-131, 20% of calibrators for Tc-99m and 15% of calibrators for I-123 had a deviation in the range 5%< $|{\Delta}|{\leq}10%$. 2% of calibrators for I-131, 19% of calibrators for Tc-99m and 18% of calibrators for I-123 had a deviation of $|{\Delta}|$ >10%. Follow-up measurements were performed on the calibrators whose error exceeded the ${\pm}10%$ limit. As a result, some of the calibrator showed an improvement and their deviation decreased below the ${\pm}10%$ limit. The results have shown that such comparisons are necessary to improve the accuracy of the measurement and to identify malfunctioning radionuclide calibrators.

우수한 핵의학 영상의 획득과 불필요한 환자 피폭을 최소화하기 위한 가장 중요한 요소 중 하나가 방사성의약품의 방사능을 정확하게 측정하는 것이다. 이를 위해서는 각 의료기관에서 사용하고 있는 방사능측정기에 대한 적절한 품질관리가 수행되어야 한다. 따라서 본 연구에서는 국내 의료기관이 보유하고 있는 방사능측정기의 품질관리를 지원하고 의료기관이 사용하고 있는 방사능측정기의 측정 정확도를 평가하고자 방사능비교측정을 수행하였다. 방사능비교측정은 I-131, Tc-99m, I-123을 이용하여 각각 수행하였다. I-131을 이용한 방사능 비교측정에는 45개 기관의 58개 방사능측정기가 참여하였고, Tc-99m의 경우 58개 기관의 74개 방사능측정기가 참여하였으며, I-123의 경우는 45개 기관 60개 방사능 측정기가 참여하였다. 편차가 ${\pm}10%$를 벗어나는 측정기에 대해서는 추가적인 비교측정을 수행하였으며, 그 결과 일부 측정기는 편차가 ${\pm}10%$ 이내로 개선되었다. 비교측정 결과 편차가 ${\pm}5%$ 이내인 측정기가 각각 81% (I-131), 61% (Tc-99m), 67% (I-123)이었고, 편차가 5%< $|{\Delta}|{\leq}|10%$ 이내인 측정기는 각각 17% (I-131), 20% (Tc-99m), 15% (I-123)이었으며, 편차가 ${\pm}10%$를 초과한 측정기는 각각 2% (I-131), 19% (Tc-99m), 18% (I-123)이었다. 본 연구의 결과로부터 방사능비교측정은 의료기관의 방사능 측정 정확도를 향상시키고, 방사능측정기의 측정 정확도 저하여부를 확인하기 위해 지속적으로 수행되어져야 할 것으로 생각한다.

Keywords

References

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