Journal of the East Asian Society of Dietary Life (동아시아식생활학회지)

The East Asian Society of Dietary Life (동아시아식생활학회)
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A Study of the Levels of Serum Lipid, Insulin and Plasma Ascorbic Acid in Obese College Men

비만 남자 대학생의 혈청 지질, 인슐린 및 혈장 아스코르브산의 농도에 관한 연구

  • Goo, Jin-Young (Dept. of Food and Nutrition, Gyeongsang National University) ;
  • Kim, Gyeong-Eup (Dept. of Home Economics Education, Kyungnam University) ;
  • Park, Mi-Young (Dept. of Food and Nutrition, Gyeongsang National University) ;
  • Youn, Hee-Shang (Dept. of Pediatrics, Gyeongsang National University School of Medcine) ;
  • Kim, Sung-Hee (Dept. of Food and Nutrition, Gyeongsang National University)
  • 구진영 (경상대학교 식품영양학과) ;
  • 김경업 (경남대학교 가정교육학과) ;
  • 박미영 (경상대학교 식품영양학과) ;
  • 윤희상 (경상대학교 의과대학 소아과교실) ;
  • 김성희 (경상대학교 식품영양학과)
  • Received : 2010.05.31
  • Accepted : 2010.08.06
  • Published : 2010.08.31
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Abstract

The purpose of this study was to investigate the blood concentrations of lipids, insulin and ascorbic acid, and their correlations in obese college men in Gyeongnam area. The blood pressure was significantly higher (p<0.001) in the obese group($127.8{\pm}7.2/86.7{\pm}9.2\;mmHg$) than the control group($112.8{\pm}6.6/71.9{\pm}6.6\;mmHg$). The serum triglyceride (p<0.01), total cholesterol (p<0.01), LDL-cholesterol (p<0.05), insulin (p<0.001) concentrations and atherogenic index (AI) (p<0.001) were significantly higher in the obese group ($158.8{\pm}79.7\;{\mu}U/L$, $185.0{\pm}26.8\;{\mu}U/L$, $111.9{\pm}28.1\;{\mu}U/L$, $15.2{\pm}5.6\;{\mu}U/L$, $3.6{\pm}1.0$) than the control group($111.9{\pm}35.8\;{\mu}U/L$, $165.9{\pm}19.4\;{\mu}U/L$, $97.0{\pm}16.4\;{\mu}U/L$, $8.9{\pm}4.4\;{\mu}U/L$, $2.6{\pm}0.3$), but HDL-cholesterol concentration was significantly higher (p<0.01) in the control group($46.5{\pm}7.2\;{\mu}U/L$) than the obese group($41.3{\pm}6.9\;{\mu}U/L$). On the other hand, there was no significant difference in the plasma ascorbic acid concentration in both groups. The ascorbic acid concentration was negatively correlated with total cholesterol level in the control group, and with triglyceride, total cholesterol levels and diastolic blood pressure in the obese group (p<0.05). These data show that young adult obesity might be related to hyperlipidemia, atherosclerosis, hypertension and diabetes mellitus, and that the nutrition of ascorbic acid is more important for obese males than normal weight males.

Keywords

References

  1. Amaral JF, Thompson WR (1995) Bladder disease in the morbidly obese. American J Surgery 149: 551-557.
  2. Ashwell M (1994) Obesity in men and women. Int J Obes Relat Metab Disord 18(S): S1-S7.
  3. Bobek P, Ginter E (1978) Serum triglycerides and post-heparin lipolytic activity in guinea pigs with latent vitamin C deficiency. Experientia 34: 1554-1559. https://doi.org/10.1007/BF02034669
  4. Bokan GA, Sparrow D, Wisniewski C (1996) Body weight and coronary heart disease risk: patterns of risk factor change associated with long term weight change. Am J Epidemiol 124: 410-419.
  5. Bordia AK (1981) The effect of vitamin C on blood lipids, fibrinolytic activity and platelet adhesiveness in patients with coronary artery disease. Atherosclerosis 35: 181-187.
  6. Brambilla P, Manzoni P, Sirone S, Simoni P, Del Maschio A, di Natale B, Chiumello G (2004) Peripheral and abdominal adiposity in childhood obesity. Int J Obes 18: 795-800.
  7. Caro JF (1991) Insulin resistance in obese and non-obese man. J Clin Endocrinol Metab 73: 691-696. https://doi.org/10.1210/jcem-73-4-691
  8. Castelli WP, Garrison RJ, Wilson PW, Abbott RD, Kalousdian S, Kannel WB (1996) Incidence of coronary heart disease and lipoprotein cholesterol levels. JAMA 256: 2835-2838.
  9. Choi ESK, Jacques PF, Dallal GE, Jacob RA (1991) Correlation of blood pressure with plasma ascorbic acid. Nutr Res 11: 1377-1382. https://doi.org/10.1016/S0271-5317(05)80470-1
  10. Choi JW, Choe HW, Pai SW (2003) Serum lipid concentrations correlate more strongly with total body fat than BMI in obese humans. Clinica Chimica Acta 329: 83-87. https://doi.org/10.1016/S0009-8981(03)00018-4
  11. Choi MG, Park SW, Park CG, Lee BD, Lee HG, Goo CS, Min HG (1988) The effect of body fat distribution on glucose metabolism in nondiabetic young men. Kor J Med 35: 167-176.
  12. Despres JP, Allard C, Tremblay A, Talbot J, Bouchard C (1995) Evidence for a regional component of body fatness in the association with serum lipids in men and women. Metabolism 34: 867-974.
  13. Despres JP, Moorjani S, Ferland M, Tremblay A, Lupien PJ, Nadeau A, Pinault S, Theriault G, Bouchard C (1999) Adipose tissue distribution and plasma lipoprotein levels in obese women: Importance of intra-abdominal fat. Arteriosclerosis 9: 203-210.
  14. Erden F, Gulenc S, Torun M, Kocer Z, Simsek B, Nebioglu S (1985) Ascorbic acid effect on some lipid fractions in human beings. Acta Vitaminol Enzymol 17: 31-88.
  15. Feldman EB, Gold S, Greene J, Moran J, Xu G, Shultz GG, Hames CG, Feldman DS (1992) Ascorbic acid supplements and blood pressure; A four week pilot study. Ann NY Acad Sci 669: 342-344. https://doi.org/10.1111/j.1749-6632.1992.tb17118.x
  16. Friedewald WT, Levy RI, Fredrickson DS (1972) Estimation of the concentration of low density lipoprotein cholesterol without use of the preparative ultracentrifuge. Clin Chem 18: 499-502.
  17. Friedman MI (1995) Control of energy intake by energy metabolism. Am J Clin Nutr 62: 1096s-1100s. https://doi.org/10.1093/ajcn/62.5.1096S
  18. Friedman MI, Ramirez I (1985) Relationship of fat metabolism to food intake. Am J Clin Nutr 42: 1093-1098. https://doi.org/10.1093/ajcn/42.5.1093
  19. Fujinami T (1985) Atherosclerosis and dietary minor components with special reference on ascorbic acid. J Jpn Atheroscler Soc 13: 739-749. https://doi.org/10.5551/jat1973.13.4_739
  20. Greco AM, La Rocca L (1989) Correlation between chronic hypovitaminosis C in old age and plasma levels of cholesterol and triglyceride. Int Vitam Nutr Res 23: 129-136.
  21. Hubert HB, Feinleib M, McNamara PM, Castelli WP (1983) Obesity as an independent risk factor for cardiovascular disease: A 26-year follow up of participants in the Framingham Heart Study. Circulation 67: 969-977.
  22. Jabb SA, Prentice AM, Goldberg GR, Murgatroyd PR, Black AE, Coward WA (1996) Changes in macronutrient balance during over- and underfeeding assessed by 12-d continuous whole body calorimetry. Am J Clin Nutr 64: 259-266. https://doi.org/10.1093/ajcn/64.3.259
  23. Jacques PF (1992) Relationship of vitamin C status to cholesterol and blood pressure. Ann NY Acad Sci 669: 205-213. https://doi.org/10.1111/j.1749-6632.1992.tb17101.x
  24. Kannel WB, Dawber TR (1993) Hypertensive cardiovascular disease: Hypertension; Mechanism & management. p 902.
  25. Kim SH, Kim GE, Kim SY (1998) A study on relations of obesity to the serum lipid and insulin concentrations in the elementary school children. Korean J Nutrition 31: 159-165.
  26. Kim SK (1995) The relationship between body fat, serum lipids, insulin and nutrients intake in obese and non-obese male students. Korean J Nutrition 28: 1056-1064.
  27. Kim SK, Kim HJ (1998) Comparison of the blood lipids, insulin and nutrients intake by fat distribution of obese male in Korea. Korean J Nutrition 31: 72-79.
  28. Kissebah AM, Freedman DS, Peiris AN (1989) Health risks of obesity. Med Clin N Am 73: 111-138. https://doi.org/10.1016/S0025-7125(16)30695-2
  29. Koh ET, Chi MS, Frank FW (1990) Comparison of selected blood components by race, sex and age. Am J Clin Nutr 33: 1828-1835.
  30. Krotkiewski M, Bjorntorp P, Sjostrom L, Smith U (1989) Impact of obesity on metabolism in men and women: Importance of regional adipose tissue distribution. J Clin Invest 72: 1150-1162.
  31. Lee YJ, Song KH (1996) A study on the body fat content and serum lipids in college students. J Korean Soc Food Nutr 25: 11-20.
  32. Linfos EW, Feussner JR, Blessing CL (1994) Spurious hypertension in the obese patient: Effect of sphygmoma-nometer cuff size on prevalence of hypertension obese patient. Arch Intern Med 144: 1482-1487.
  33. Messerli FH (1992) Cardiovascular effects obesity and hypertension. Lancet 1: 1165-1168.
  34. Ministry of Health & Welfare (2006) 2005 National Health and Nutrition Survey.
  35. Moran JP, Cohen L, Greene JM, Xu G, Feldman EB, Hames CG, Feldman DS (1993) Plasma ascorbic acid concentrations relate inversely to blood pressure in human subjects. Am J Clin Nutr 57: 213-217. https://doi.org/10.1093/ajcn/57.2.213
  36. Park HS, Cho HJ, Kim CJ (1992) The diseases associated with obesity in Korean adults. J Kor Acad Fam Med 13: 344-353.
  37. Pekkanen J, Linn S, Heiss G (1990) Ten-year mortality from cardiovascular disease in relation to cholesterol level among men with and without preexisting cardiovascular disease. N Engl J Med 322: 1700-1707. https://doi.org/10.1056/NEJM199006143222403
  38. Shin JH, Nam SY, Kim ES, Kim KR, Cha BS, Song YD, Song YD, Lim SK, Lee HC, Huh KB (1998) Serum immunoreactive- leptin concentrations to adiposity and other biochemical parameters in Korean adults. J Korean Soc Endocrinology 13: 216-222.
  39. Toohey L, Harris MA, Allen KGD, Melby CL (1996) Plasma ascorbic acid concentrations are related to cardiovascular risk factors in African-Americans. J Nutr 126: 121-128. https://doi.org/10.1093/jn/126.1.121
  40. Trout DL (1991) Vitamin C and cardiovascular risks. Am J Clin Nutr 53: 322s-325s. https://doi.org/10.1093/ajcn/53.1.322S
  41. Turkington RW, Estkowski A, Link M (1982) Secretion of insulin or connecting peptide: A predictor of insulin dependence of obese 'diabetics'. Arch Intern Med 82: 1102-1105.
  42. WHO (2000) Technical Report Series No. 894. Obesity: Preventing and Managing in the Global Epidemic.
  43. Yanai M, Kon A, Kumasaka K, Kawano K (1997) Body mass index variations by age and sex, and prevalence of overweight in Japanese adults. Int J Obes 21: 484-488. https://doi.org/10.1038/sj.ijo.0800434
  44. Yoshioka M, Matsushita T, Chuman Y (1984) Inverse association of serum ascorbic acid level and blood pressure or rate of hypertension in male adults aged 30-39 years. Int Vitam Nutr Res 54: 343-347.
  45. Zwiauer K, Widhalm K, Kerbl B (1990) Relationship between body fat distribution and blood lipids in obese adolescents. Int J Obes 14: 271-277.