Journal of Radiation Protection and Research

The Korean Association for Radiation Protection (대한방사선방어학회)
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RABBIT HEATING BY MICROWAVE EXPOSURE AT VARIOUS AMBIENT TEMPERATURES

  • Kolganova, Olga I. (Medical Radiological Research Center) ;
  • Zhavoronkov, Leonid P. (Medical Radiological Research Center) ;
  • Petin, Vladislav G. (Medical Radiological Research Center) ;
  • Kim, Jin-Kyu (Korea Atomic Energy Research Institute, Advanced Radiation Technology Institute)
  • Received : 2010.08.03
  • Accepted : 2010.09.16
  • Published : 2010.09.30
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Abstract

The potential ability of environmental temperature to enhance the effect of microwave radiation (7 GHz) was experimentally studied for rabbit heating after simultaneous application of both agents. The tested ambient temperatures (30 and $38^{\circ}C$) didn't exert a considerable influence upon rabbit heat homeostasis after the used duration of exposure (3 hours and 15 minutes, correspondingly). The synergistic interaction of microwave irradiation and ambient temperature was demonstrated for rabbit heating. Power flux density of microwave irradiation was shown to be a determinant of the synergistic interaction effectiveness. For the fixed ambient temperature ($30^{\circ}C$), the synergism was shown to be observed only within a definite power flux density ($0-100\;mW{\cdot}cm^{-2}$), inside of which there was an optimal intensity ($20\;mW{\cdot}cm^{-2}$), which maximized the synergistic effect. Any deviation of the power flux density from the optimal value resulted in a reduction of the synergy. It is concluded that any assessment of the health or environmental risks should take into account the synergistic interaction between ambient temperature and microwave radiation.

Keywords

References

  1. Hahn GW. Hyperthermia and Cancer. New York; Plenum Press, 1982.
  2. Streffer C, Vaupel P, Hahn G. Biological Basis of Oncologic Thermotherapy. Berlin, Heidelberg; Springer Verlag, 1990.
  3. Streffer C, Bucker J, Cansier A, Cansier D, Gethmann CF, Guderian R, Hanekamp G, Henschler D, Poch G, Rehbinder E, Renn O, Slesina M, Wuttke K. Environmental Standards: Combined Exposures and Their Effects on Human Beings and Their Environment. Berlin, Heidelberg; Springer Verlag, 2003.
  4. Kim JK, Petin VG, Zhurakovskaya GP. Exposure rate as a determinant of synergistic interaction of heat combined with ionizing or ultraviolet radiations in cell killing. J. Radiat. Res. 2001; 42(4):361‐365. https://doi.org/10.1269/jrr.42.361
  5. Petin VG, Kim JK, Zhurakovskaya GP, Dergacheva IP. Some general regularities of synergistic interaction of hyperthermia with various physical and chemical inactivating agents. Int. J. Hyperther. 2002; 181(1):40‐49.
  6. Petin VG, Kim JK. Survival and recovery of yeast cells after combined treatments with ionizing radiation and heat. Radiat. Res. 2004; 161(1):56‐63. https://doi.org/10.1667/RR3100
  7. Petin VG, Zhurakovskaya GP, Kim JK. Synergetic effects of different pollutants and equidosimetry. In: Brechignac F, Desmet G, eds. Equidosimetry -Ecological Standardization and Equidosimetry for Radioecology and Environmental Ecology. Berlin, Heidelberg; Springer Verlag, 2005:207‐222.
  8. Michaelson SM. Thermal effects of single and repeated exposures to microwaves - a review. In: Czerski P, Ostrowski K, Shore ML, Silverman Ch, Suess VJ, Waldeskog B, eds. Biological Effects and Health Hazards of Microwave Radiation. Warsaw; Polish Medical Publishers, 1974:1‐14.
  9. Michaelson SM. Thermoregulation in intense microwave fields. In: Adair ER, ed. Microwaves and Thermoregulation. New York; Academic Press, 1983:283‐295.
  10. Nikonova KV, Sokolova IP. The characteristics of biologic effects of microwaves combined with the action of soft X‐ray irradiation and heat. In: Czerski P, Ostrowski K, Shore ML, Silverman Ch, Suess VJ, Waldeskog B, eds. Biologic Effects and Health Hazards of Microwave Radiation. Warsaw; Polish Medical Publishers, 1974:58‐66.
  11. Gordon CJ, Long MD, Fehlner KS. Temperature regulation in the unrestrained rabbit during exposure to 600 MHz radiofrequency radiation. Int. J. Radiat. Biol. 1986; 49(6):987‐997. https://doi.org/10.1080/09553008514553211
  12. Gordon CJ, Long MD, Fehlner RS, Stead AG. Temperature regulation in the mouse and hamster exposed to microwaves in hot environments. Health Phys. 1986; 50(6):781‐787. https://doi.org/10.1097/00004032-198606000-00009
  13. Gordon CJ, Ali JS. Comparative thermoregulatory response to passive heat loading by exposure to radiofrequency radiation. Comp. Biochem. Physiol. 1987; 88(1):107‐112. https://doi.org/10.1016/0300-9629(87)90107-1
  14. Adair ER, Cobb BL., Mylacraine KS, Kelleher SA. Human exposure at two radio frequencies (450 and 2450 MHz): similarities and differences in physiological response. Bioelectromagnetics 1999; 20(Suppl. 4):12‐20.
  15. Adair ER, Mylacraine KS, Cobb BL. Partial‐body exposure of human volunteers to 2450 MHz pulsed or CW fields provokes similar thermoregulatory responses. Bioelectromagnetics 2001; 22(4):246‐259. https://doi.org/10.1002/bem.47
  16. Petin VG, Dubovick BV, Rojkov MF, Komarov VP. Application of dose parameters of UHF‐irradiation for interpretation of lethal effects in laboratory animals. Radiat. Biol. Radioecol. 1996; 36(2):310‐316.
  17. Zhavoronkov LP, Petin VG. The dose‐power approach in hygienic standardization of microwaves: the concept, biophysical modeling, experimental estimation. In: Repacholi MH, Rubtsova NB, Muc AM, eds. Electromagnetic Fields: Biological Effects and Hygienic Standardization. World Health Organization, Geneva, Switzerland, 1999: 457‐465.
  18. Petin VG, Zhurakovskaya GP, Kalugina AV. Microwave dosimetry and lethal effects in laboratory animals. In: Klauenberg BJ, Miklavcic D, eds. Radio Frequency Radiation Dosimetry and Its Relationship to the Biological Effects of Electromagnetic Fields. Kluwer Academic Publishers, 2000:375‐382.
  19. Kolganova ON, Zhavoronkov LP, Petin VG, Drozd AI, Glushakova VS, Panferova TA. Thermocompensate rabbit responses to the microwave exposure at various environmental temperatures. Radiat. Biol. Radioecol. 2001; 41(6):712‐717.
  20. McRee DI. Determination of the absorption of microwave radiation by biological specimens in a 2450 MHz microwave field. Health Physics 1974; 26 (5):385-390. https://doi.org/10.1097/00004032-197405000-00001
  21. Brannen JP. A temperature‐ and dose rate‐dependent model for kinetics of cellular response to ionizing radiation. Radiat. Res. 1975; 62(3):379‐387. https://doi.org/10.2307/3574133
  22. Ben‐Hur E. Mechanisms of the synergistic interaction between hyperthermia and radiation in cultured mammalian cells. J. Radiat. Res. 1976; 17(1):92‐98. https://doi.org/10.1269/jrr.17.92
  23. Petin VG, Zhurakovskaya GP. The peculiarities of the interaction of radiation and hyperthermia in Saccharomyces cerevisiae irradiated with various dose rates. Yeast 1995; 11(6):549‐554. https://doi.org/10.1002/yea.320110604
  24. Petin VG, Komarov VP. Mathematical description of synergistic interaction of hyperthermia and ionizing radiation. Mathem. Biosci. 1997; 146(2):115‐130. https://doi.org/10.1016/S0025-5564(97)00078-3
  25. Petin VG, Kim JK, Zhurakovskaya GP, Rassokhina AV. Mathematical description of synergistic interaction of UV light and hyperthermia for yeast cells. J. Photochem. Photobiol. B: Biol. 2000; 55(1):74‐79. https://doi.org/10.1016/S1011-1344(00)00035-X
  26. Petin VG, Zhurakovskaya GP, Komarova LN. Mathematical description of combined action of ultrasound and hyperthermia on yeast cells. Ultrasonics 1999; 37(1):79‐83. https://doi.org/10.1016/S0041-624X(98)00035-3
  27. Petin VG, Dergacheva IP, Romanenko AG, Ryabova SV. A new concept of optimization and prediction of synergism effects during the combined action of chemical and physical factors of the environment. Mendeleev Chemistry J. 1997; 41(3):129‐140.
  28. Kolganova OI, Drozd AI, Zhavoronkov LP, Baranov VD, Glushakova VS, Panferova TA. The experimental estimation of the thermogenic levels of the acute microwave exposure for different species of animals. Radiat. Biol. Radioecol. 2000; 40(6):696‐701.
  29. Kolganova OI, Zhavoronkov LP, Matrenina VL, Posadskaya VM. Influence of microwave exposure at elevated temperature on the thermocompensate responses of small laboratory animals. Radiat. Biol. Radioecol. 2003; 43(6):678‐681.
  30. Adair ER. Microwaves and Thermoregulation. New York; Academic Press, 1983.