Environmental Analysis Health and Toxicology

환경독성보건학회 (The Korean Society of Environmental Health and Toxicology)
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Monitoring of the Distribution of Ambient Air Particles in Seoul Using a Cascade Impactor and the Particle Toxicity

  • 발행 : 2010.06.30
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초록

The distribution of ambient air particles varies according to climate, industries, and other sources. In this study, ambient air particles (less than 12.1 ${\mu}m$) were monitored from February to August, 2007 as 12 different fractions sorted by a cascade impactor. Particles in the size range from 0.33 ${\mu}m$ to 0.76 ${\mu}m$ comprised the main fraction of ambient air particles in Seoul, Korea. On the day of an Asian dust event, the particle fraction size increased to 1.25~2.5 ${\mu}m$. The different sized particle fractions were also monitored for metals and were found to contain toxic heavy metals including Pb, Cd, Hg, Cr and As. Particle preparations were significantly cytotoxic when exposed to cultured BEAS-2B cells. Microarray analysis of the treated cells indicated a significant up-regulation of a number of genes associated with oxidative stress, including metallothionein, heme oxygenase-1, heat shock protein 70, and NAD(P)H dehydrogenase-1.

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참고문헌

  1. Baranano DE, Rao M, Ferris CD and Snyder SH. Biliverdin reductase: a major physiologic cytoprotectant, Proc Natl Acad Sci USA. 2002; 99(25): 16093-16098. https://doi.org/10.1073/pnas.252626999
  2. Brandli O. Are inhaled dust particles harmful for our lungs?, Schweiz Med Wochenschr 1996; 126(50): 2165-2174.
  3. Chang CC, Tsai SS, Ho SC and Yang CY. Air pollution and hospital admissions for cardiovascular disease in Taipei, Taiwan, Environ Res 2005; 98(1): 114-119. https://doi.org/10.1016/j.envres.2004.07.005
  4. de Hartog JJ, Hoek G, Mirme A, Tuch T, Kos GP, ten Brink HM, Brunekreef B, Cyrys J, Heinrich J, Pitz M, Lanki T, Vallius M, Pekkanen J and Kreyling WG. Relationship between different size classes of particulate matter and meteorology in three European cities, J Environ Monit 2005; 7(4): 302-310. https://doi.org/10.1039/b415153d
  5. Hart JE, Laden F, Schenker MB and Garshick E. Chronic obstructive pulmonary disease mortality in diesel-exposed railroad workers, Environ Health Perspect 2006; 114(7): 1013-1017. https://doi.org/10.1289/ehp.8743
  6. Joseph P, He Q and Umbright C. Heme-oxygenase 1 gene expression is a marker for hexavalent chromium-induced stress and toxicity in human dermal fibroblasts, Toxicol Sci 2008; 103(2): 325-334. https://doi.org/10.1093/toxsci/kfn048
  7. Karar K, Gupta AK, Kumar A and Biswas AK. Seasonal variations of $PM_{10}$ and TSP in residential and industrial sites in an urban area of Kolkata, India, Environ Monit Assess 2006; 118(1-3): 369-381. https://doi.org/10.1007/s10661-006-1503-9
  8. Kim KH and Kim MY. The effects of Asian Dust on particulate matter fractionation in Seoul, Korea during spring 2001, Chemosphere 2003; 51(8): 707-721. https://doi.org/10.1016/S0045-6535(03)00036-5
  9. Koren HS. Associations between criteria air pollutants and asthma, Environ Health Perspect. 1995; 103(Suppl 6): 235-242. https://doi.org/10.1289/ehp.95103s6235
  10. Lee BK, Lee HK and Jun NY. Analysis of regional and temporal characteristics of $PM_{10}$ during an Asian dust episode in Korea, Chemosphere 2006; 63(7): 1106-1115. https://doi.org/10.1016/j.chemosphere.2005.09.001
  11. Lewtas J. Air pollution combustion emissions: characterization of causative agents and mechanisms associated with cancer, reproductive, and cardiovascular effects, Mutat Res 2007; 636(1-3): 95-133. https://doi.org/10.1016/j.mrrev.2007.08.003
  12. Liu G, Niu Z, Van Niekerk D, Xue J and Zheng L. Polycyclic aromatic hydrocarbons (PAHs) from coal combustion: emissions, analysis, and toxicology, Rev Environ Contam Toxicol 2008; 192: 1-28. https://doi.org/10.1007/978-0-387-71724-1_1
  13. Marconi A, Cattani G, Cusano M, Ferdinandi M, Inglessis M, Viviano G, Settimo G and Forastiere F. Two-years of fine and ultrafine particles measurements in Rome, Italy, J Toxicol Environ Health A 2007; 70(3-4): 213-221. https://doi.org/10.1080/15287390600883174
  14. Morse D, Lin L, Choi AM and Ryter SW. Heme oxygenase-1, a critical arbitrator of cell death pathways in lung injury and disease, Free Radic Biol Med 2009; 47(1): 1-12. https://doi.org/10.1016/j.freeradbiomed.2009.04.007
  15. Mukhopadhyay D, Mitra A, Nandi P, Varghese AC, Murmu N, Chowdhury R, Chaudhuri K and Bhattacharyya AK. Expression of metallothionein-1 (MT-1) mRNA in the rat testes and liver after cadmium injection, Syst Biol Reprod Med 2009; 55(5-6): 188-192. https://doi.org/10.3109/19396360903114429
  16. Naspinski C, Lingenfelter R, Cizmas L, Naufal Z, He LY, Islamzadeh A, Li Z, Li Z, McDonald T and Donnelly KC. A comparison of concentrations of polycyclic aromatic compounds detected in dust samples from various regions of the world, Environ Int 2008; 34(7): 988-993. https://doi.org/10.1016/j.envint.2008.03.008
  17. Oberdorster G, Oberdorster E and Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles, Environ Health Perspect 2005; 113(7): 823-839. https://doi.org/10.1289/ehp.7339
  18. O'Connell S, Au-Yeung HK, Gregory CJ and Matthews IP. Outdoor and indoor respirable air particulate concentrations in differing urban traffic microenvironments, J Toxicol Environ Health A 2008; 71(16): 1069-1072. https://doi.org/10.1080/15287390802112000
  19. Park EJ, Kim DS and Park K. Monitoring of ambient particles and heavy metals in a residential area of Seoul, Korea, Environ Monit Assess 2008; 137(1-3): 441-449. https://doi.org/10.1007/s10661-007-9779-y
  20. Park EJ and Park K. Gene expression profiles of cultured rat cardiomyocytes (H9C2 cells) in response to arsenic trioxide at subcytotoxic level and oxidative stress, J Health Sci 2006; 52(2): 512-521. https://doi.org/10.1248/jhs.52.512
  21. Rajsic SF, Tasic MD, Novakovic VT and Tomasevic MN. First assessment of the $PM_{10}$ and $PM_{2.5}$ particulate level in the ambient air of Belgrade city, Environ Sci Pollut Res Int 2004; 11(3): 158-164. https://doi.org/10.1007/BF02979670
  22. Roberts S and Martin MA. Methods for bias reduction in time-series studies of particulate matter air pollution and mortality, J Toxicol Environ Health A 2007; 70(18): 665-675. https://doi.org/10.1080/15287390600974668
  23. Rodriquez S, Querol X, Alastuey A, Viana MM, Alarcon M, Mantilla E and Ruiz CR. Comparative $PM_{10}-PM_{2.5}$ source contribution study at rural, urban and industrial sites during PM episodes in Eastern Spain, Sci Total Environ 2004; 328(1-3): 95-113. https://doi.org/10.1016/S0048-9697(03)00411-X
  24. Schafer M and Werner S. Oxidative stress in normal and impaired wound repair, Pharmacol Res 2008; 58(2): 165-171. https://doi.org/10.1016/j.phrs.2008.06.004
  25. Schwela D. Air pollution and health in urban areas, Rev Environ Health 2000; 15(1-2): 13-42. https://doi.org/10.1515/REVEH.2000.15.1-2.13
  26. Stone V, Johnston H and Clift MJ. Air pollution, ultrafine and nanoparticle toxicology: cellular and molecular interaction, IEEE Trans Nanobioscience 2007; 6(4): 331-340. https://doi.org/10.1109/TNB.2007.909005
  27. Valavanidis A, Fiotakis K and Vlachogianni T. Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic mechanisms, J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2008; 26(4): 339-362. https://doi.org/10.1080/10590500802494538
  28. Wilson AM, Salloway JC, Wake CP and Kelly T. Air pollution and the demand for hospital services: a review, Environ Int 2004; 30(8): 1109-1118. https://doi.org/10.1016/j.envint.2004.01.004
  29. Yang CY, Cheng MH and Chen CC. Effects of Asian Dust storm events on hospital admissions for congestive heart failure in Taipei, Taiwan, J Toxicol Environ Health A 2009; 72(5): 324-328. https://doi.org/10.1080/15287390802529880
  30. Yang M and Chitambar CR. Role of oxidative stress in the induction of metallothionein-2A and heme oxygenase-1 gene expression by the antineoplastic agent gallium nitrate in human lymphoma cells, Free Radic Biol Med 2008; 45(6): 763-772. https://doi.org/10.1016/j.freeradbiomed.2008.05.031
  31. Yasui NY and Akagi M. Possibility of heme oxygenase-1 as a target for therapy against allergic inflammation, Nippon Yakurigaku Zasshi 2007; 130(4): 257-261. https://doi.org/10.1254/fpj.130.257
  32. Zimmer AT. The influence of metallurgy on the formation of welding aerosols, J Environ Monit 2002; 4(5): 628-632. https://doi.org/10.1039/b202337g