한국동물위생학회지 (Korean Journal of Veterinary Service)

  • 제33권2호
  • /
  • Pages.173-176
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  • 2010
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  • 3022-7372(pISSN)
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  • 2287-7630(eISSN)
한국동물위생학회 (The Korean Society of Veterinary Service)
권호 표지

키토산 resin formulae의 서방효과(sustained-releasing effect) 보조제로서의 활용

Application of chitosan resin formulae as a sustained-releasing form adjuvant

  • Kim, Sang-Uk (Jeollanamdo Institute of Livestock & Veterinary Science) ;
  • Kang, Mun-Il (College of Veterinary Medicine, Chonnam National University) ;
  • Lee, Jae-Il (College of Veterinary Medicine, Chonnam National University) ;
  • Kim, Tae-Jung (College of Veterinary Medicine, Chonnam National University)
  • 투고 : 2010.03.28
  • 심사 : 2010.06.11
  • 발행 : 2010.06.30
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초록

Here, we report the suitability of using a resin-type chitosan formulae as a sustained-releasing form adjuvant in comparison with commercially well-known Freund's adjuvants. To induce the immunological responses, N-terminal region of Pasteurella multocida toxin was used as an antigen, which was found to be protective immunogen against P. multocida infection. Mice immunized with chitosan resin formulae showed statistically significant antibody induction (P<0.001) as much as that of Freund’s adjuvants. As a result, the resin-type sustained-releasing form chitosan formulae is thought to be a good candidate for a new type adjuvant.

키워드

참고문헌

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