Journal of the korean academy of Pediatric Dentistry (대한소아치과학회지)

Korean Academy of Pediatric Dentistry (대한소아치과학회)
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THE EFFECTS OF CHEMORADIATION THERAPY FOR NEUROBLASTOMA ON DENTAL CARIES ACTIVITY

신경모세포종의 화학 및 방사선요법이 치아우식활성도에 미치는 영향

  • Lee, Ji-Hyun (Department of Pediatric Dentistry, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Park, Ki-Tae (Department of Pediatric Dentistry, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Sung, Ki-Woong (Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine) ;
  • Kim, Ji-Yeon (Department of Pediatric Dentistry, Samsung Medical Center, Sungkyunkwan University School of Medicine)
  • 이지현 (성균관대학교 의과대학 삼성서울병원 소아치과) ;
  • 박기태 (성균관대학교 의과대학 삼성서울병원 소아치과) ;
  • 성기웅 (성균관대학교 의과대학 삼성서울병원 소아청소년과) ;
  • 김지연 (성균관대학교 의과대학 삼성서울병원 소아치과)
  • Received : 2010.02.07
  • Accepted : 2010.06.07
  • Published : 2010.08.31
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Abstract

Chemotherapy or radiotherapy used for the treatment of pediatric cancer may have many adverse effects on the oral cavity. Oral mucositis, reduced salivary flow, oral infection, hypodontia, microdontia, arrested root development, and enamel hypoplasia are common oral complications. The aim of this study is to evaluate the effects of cancer therapy on dental caries activities. The children who had been treated for neuroblastoma in the department of pediatrics, Samsung Medical Center, were included and healthy children served as controls. The salivary flow rate, salivary buffering capacity, and Streptococcus mutans counts of both groups were evaluated using Dentocult$^{(R)}$ SM and Dentobuff$^{(R)}$ Strip. The dental caries activity related to the age at the start of treatment and the time elapsed since treatment completion were also evaluated. As a result, neuroblastoma patients had significantly lower salivary flow rate than the controls, while there were no significant differences between two groups as for salivary buffering capacity and Streptococcus mutans counts. The dental caries activities related to the age at the start of treatment and the time elapsed since treatment completion were not significantly different.

소아암 환자의 치료 방법으로 주로 사용되는 항암화학요법이나 방사선요법이 구강 건강에 미치는 영향은 매우 크다. 구강점막염, 타액 분비율의 변화, 구강내 감염을 야기할 수 있고, 부분무치증, 왜소치, 치근 발육이상, 저석회화증이 나타날 수 있다. 본 연구는 신경모세포종으로 치료 받은 환아들에 있어 항암치료가 치아우식증 발생 위험도에 어떠한 영향을 미치는지 알아보기 위해 실시되었다. 삼성서울병원 소아청소년과에 신경모세포종으로 내원하여 화학 및 방사선치료요법을 받은 환아들을 대상으로 Dentocult$^{(R)}$ SM, Dentobuff$^{(R)}$ Strip을 이용하여 항암치료 후의 타액 분비율, 타액 완충능, 타액 내의 Streptococcus mutans 수를 알아보고 정상 어린이들의 결과와 비교하였으며, 신경모세포종 환아에서 처음 치료를 시작한 나이, 치료 종결 후 경과 시간에 따라 치아우식활성도가 어떻게 달라지는지에 대해서도 알아보았다. 그 결과 타액 분비율은 환아가 대조군에 비해 유의성 있게 낮은 결과를 보인 반면(p<0.05), 타액 완충능과 Streptococcus mutans 수는 환아와 대조군 간에 유의성 있는 차이를 보이지 않았다. 환아에서 치료를 시작한 나이나 치료 종결 후 경과 시간에 따른 치아우식활성도에서도 통계적 유의차는 없었다.

Keywords

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