대한기관식도과학회지 (Korean Journal of Bronchoesophagology)
- 제16권1호
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- Pages.39-46
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- 2010
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- 1226-0916(pISSN)
두경부 편평세포암에서 c-Met 단백과 Ki-67 발현의 의의
The Significance of c-Met and Ki-67 Expression in the Head and Neck Squamous Cell Carcinoma
- 김준 (조선대학교 의과대학 이비인후과학교실) ;
- 도남용 (조선대학교 의과대학 이비인후과학교실) ;
- 박준희 (조선대학교 의과대학 이비인후과학교실) ;
- 최지윤 (조선대학교 의과대학 이비인후과학교실) ;
- 임성철 (조선대학교 의과대학 병리학교실)
- Kim, Jun (Department of Otolaryngology, Chosun University) ;
- Do, Nam-Yong (Department of Otolaryngology, Chosun University) ;
- Park, Jun-Hee (Department of Otolaryngology, Chosun University) ;
- Choi, Ji-Yun (Department of Otolaryngology, Chosun University) ;
- Lim, Sung-Chul (Department of Pathology, College of Medicine, Chosun University)
- 투고 : 2010.06.12
- 심사 : 2010.06.18
- 발행 : 2010.06.30
초록
Background and Objectives Various tumor markers have been studied in an attempt to evaluate and decide the optimal treatment of the patients with head and neek squamous cell carcinoma (HNSCC). A nuclear antigen Ki-67 is a proliferative marker of tumor cells in all phases of cell cycle except G0. c-met gene, the tyrosine kinase receptor for hepatocyte growth tactor, may play various roles in malignant transformation. The authors evaluated the prognostic significance of Ki-67 and c-Met in surgical specimens of HNSCC to determine the relationship with the various clinicopathological characteristics. Materials and Methods Formatin-fixed paraffin-embedded surgical specimens were obtained from 54 patients with HNSCC. Ki-67 and c-Met expressions were analyzed by immunohistochemical staning and were compared with the clinicopathological characteristics such as, pathologic differentiation, tumor stage, clinical stage and lymph node metastasis. Results Ki-67 and c-Met over-expression was detected in 66.7% and 90.7% in HNSCC. There was positive correlation of increased expression of Ki-67 with tumor stage. and clinical stage, increased expression of e-Met with tumor stage, clinical stage, and nodal status. The expression of c-Met had a significant positive relationship with Ki-67 index (p<0.05). Conclusion Therefore, Ki-67 and c-Met are useful markers of tumor progression, aggressiveness and prognosis in HNSCC.