DOI QR코드

DOI QR Code

Rheological Behaviour of Emulsions Containing Polyacrylamide

폴리아크릴아마이드를 함유한 에멀젼의 유변학적 거동

  • Cho, Wan-Goo (College of Alternative Medicine, Jeonju University) ;
  • Kim, Song-E (Household & Health Care R&D Center, LG H&H Ltd)
  • 조완구 (전주대학교 대체의학대학 가초의과학과) ;
  • 김송이 (LG 생활건강기술원 화장품연구소)
  • Received : 2010.03.31
  • Accepted : 2010.06.22
  • Published : 2010.06.30

Abstract

We have investigated the rheological behaviours of emulsions containing polymers. The polymers used in this study were polyacrylamide and carboxy vinyl polymer. The emulsion with polyacrylamide shows better prior preference than that with carboxy vinyl polymer on the skin texture. In the toxicity test, such as, LLNA cell toxicity, skin organ culture and human patch test, polyacrylamide was the appropriate materials for the cosmetics. The viscosity of polyacrylamide shows maximum value in neutral pH and good stability against temperature. The decreasing effect of viscosity against salt was not good enough but showed a better result than that of carboxy vinyl polymer. Two times the amount of polyacrylamide should be used for the formation of a similar viscosity of carboxy vinyl polymer. Yield value of polyacrylamide was low and the effect for the stabilizing emulsions was also low.

Keywords

References

  1. E. D. Goddard, Principles of polymer science and technology in cosmetics and personal care, E. D. Goddard and J. Gruber, Marcel Dekker, New York, Chapter 4, pp. 113(1999).
  2. M. Baluom, D. I. Friedman, and A. Rubinstein, Absorption enhancement of calcitonin in the rat intestine by carbopol-containing submicron emulsions, Int. J. Pharm., 154, 235 (1997). https://doi.org/10.1016/S0378-5173(97)00140-3
  3. H. Qi, W. Chen, C. Huang, L. Li, C. Chen, W. Li, and C. Wu, Development of a poloxamer analogs/carbopol-based in situ gelling and mucoadhesive ophthalmic delivery system for puerarin, Int. J. Pharm., 337, 178 (2007). https://doi.org/10.1016/j.ijpharm.2006.12.038
  4. J. N. Lee, D. J. Kim, and H. Y. Koh, Investigation of the interactions between anionic polymer and nonionic surfactant with rheological and surface tension measurements, J. Kor. Oil Chem. Soc., 24(2), 160 (2007).
  5. H. J. Yang, J. H. Kim, W. G. Cho and, S. N. Park, The stability of emulsions formed by phase inversion with variation of HLB of surfactant, J. Kor. Oil Chem. Soc., 26(2), 117 (2009).
  6. N. Dubash and I. A. Frigaard, Propagation and stopping of air bubbles in Carbopol solutions, J. Non-Newtonian Fluid Mech. 142, 123 (2007). https://doi.org/10.1016/j.jnnfm.2006.06.006
  7. B. W. Barry and M. C. Meyer, The rheological properties of carbopol gels I. Continuous shear and creep properties of carbopol gels, Int. J. Pharm., 2(1), 1 (1979). https://doi.org/10.1016/0378-5173(79)90025-5
  8. B. J. An, J. Y. Lee, C. E. Lee, J. H. Son, J. M. Park, and T. S. Park, Stability and Rheology of Cream Containing Sopoongsan, J. Kor. Soc. Appl. Biol. Chem. 48(4), 404 (2005).
  9. J. N. Lee, D. J. Kim, and H. Y. Koh, Investigation of the interaction between anionic polymer and nonionic surfactant with rheological and surface tension measurements, J. Kor. Oil Chem. Soc., 24(2), 160 (2007).
  10. R. A-sasutjarit, A. Sirivat, and P. Vayumhasuwan, Viscoelastic properties of Carbopol 940 gels and their relationships to piroxicam diffusion coefficients in gel bases, Pharm. Res., 22(12), 2134 (2005). https://doi.org/10.1007/s11095-005-8244-2
  11. M Subova, Z. Vitkova, E. Cirbusova, I. Eros, and M. Konya, Effect of polymer concentration on rheological properties of Carbopol 980 hydrogels containing trimecainium chloride, Drug Deliv. Technol., 54(2), 96 (2005).
  12. J. DeJongha, M. Nordin-Anderssonc, B. A. Ploegera, and A. Forsby, Estimation of systemic toxicity of acrylamide by integration of in vitro toxicity data with kinetic simulations, Toxicol. Appl. Pharm., 158(3), 261, (1999). https://doi.org/10.1006/taap.1999.8670