Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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A Correlation of Cognitive Function, Depression, Suicidal Idea and Serum Lipid Levels in the Elderly Over Sixty Years of Age

60세 이상 노인 인구에서 인지기능과 우울증, 자살사고, 혈청지질농도와의 연관성

  • Moon, Jung-Joon (Department of Psychiatry, Inje University College of Medicine) ;
  • Lee, Bong-Ju (Department of Psychiatry, Inje University College of Medicine) ;
  • Kim, Jeong-Eun (Department of Psychiatry, Inje University College of Medicine) ;
  • Kim, Woo-Jin (Department of Psychiatry, Inje University College of Medicine) ;
  • Kim, Min-Hyo (Department of Psychiatry, Inje University College of Medicine) ;
  • Park, Min-Kyong (Department of Psychiatry, Inje University College of Medicine) ;
  • Song, Tae-Hong (Department of Psychiatry, Inje University College of Medicine) ;
  • Shim, Joo-Cheol (Department of Psychiatry, Inje University College of Medicine) ;
  • Kim, Gyung-Mee (Department of Psychiatry, Inje University College of Medicine) ;
  • Lee, Jung-Goo (Department of Psychiatry, Inje University College of Medicine) ;
  • Kim, Young-Hoon (Department of Psychiatry, Inje University College of Medicine)
  • 문정준 (인제대학교 의과대학 정신과학교실) ;
  • 이봉주 (인제대학교 의과대학 정신과학교실) ;
  • 김정은 (인제대학교 의과대학 정신과학교실) ;
  • 김우진 (인제대학교 의과대학 정신과학교실) ;
  • 김민효 (인제대학교 의과대학 정신과학교실) ;
  • 박민경 (인제대학교 의과대학 정신과학교실) ;
  • 송태홍 (인제대학교 의과대학 정신과학교실) ;
  • 심주철 (인제대학교 의과대학 정신과학교실) ;
  • 김경미 (인제대학교 의과대학 정신과학교실) ;
  • 이정구 (인제대학교 의과대학 정신과학교실) ;
  • 김영훈 (인제대학교 의과대학 정신과학교실)
  • Received : 2010.08.23
  • Accepted : 2010.10.11
  • Published : 2010.11.30
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Abstract

Objectives : We investigated a correlation of cognitive function, depression, suicidal idea and serum lipid levels in Korean elderly over 60 years old to find risk factors of deprssion and cognitive decline. Methods : 834 persons participated in this study. Clinical evaluation was done at a point by using Mini-Mental State Examination in the Korean version of CERAD assessment packet(MMSE-KC). We also evaluated 165 persons that agreed to our exact examination for Geriatric Depression Scale(GDS), Scale for Suicidal Ideation(SSI), Hachinski Ischemic Score and serum lipid profile. Correlation analysis was used to evaluate correlation among serum lipid levels, MMSE-KC and SSI. One-way ANOVA was used for comparison of serum lipid levels and cognitive function, depression and SSI. We did a post-hoc analysis. Results : Depression and suicidal ideation were related with cognitive impairment in Korean elderly over 60 years old. Those who have more severe cognitive impairment and depressive symptom, have higher Hachinski ischemic score. We can see high HDL cholesterol levels only in the normal control group. Low total, HDL, LDL cholesterol were related with depression. Conclusion : There was high prevalence of depression in the Korean elderly over 60 years old and low serum lipid level was related with severity of depression and high suicidal ideation. In the normal control group, we can see high HDL cholesterol levels. To confirm this result, we need well-designed and wide range study.

Keywords

References

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