The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Anti-nociceptive and anti-inflammatory effects of Geranii Herba

현지초(玄之草)의 진통(鎭痛) 및 항염증(抗炎症) 효과

  • Ju, Mi-Sun (Department of Oriental Pharmaceutical Science, Kyung hee University) ;
  • Jeong, Hyun-Uk (Department of Oriental Pharmaceutical Science, Kyung hee University) ;
  • Kim, Hyo-Geun (Department of Oriental Pharmaceutical Science, Kyung hee University) ;
  • Park, Gun-Hyuk (Department of Life and Nanopharmaceutical Science, Kyung hee University) ;
  • Youn, You-Suk (Department of Oriental Rehabilitation Medicine, Neck and Back Oriental Medicine Hospital) ;
  • Kim, Young-Ock (Department of Herbal Crop Research, National Institute of Horticultural & Herbal Science) ;
  • Kim, Sun-Yeou (Graduate School of East-West Medical Science, Kyung hee University) ;
  • Oh, Myung-Sook (Department of Oriental Pharmaceutical Science, Kyung hee University)
  • 주미선 (경희대학교 약학대학 한약학과) ;
  • 정현욱 (경희대학교 약학대학 한약학과) ;
  • 김효근 (경희대학교 약학대학 한약학과) ;
  • 박건혁 (경희대학교 약학대학 나노의약생명과학과) ;
  • 윤유석 (모커리 한방병원 한방재활의학과 교실) ;
  • 김영옥 (국립원예특작과학원 인삼특작부) ;
  • 김선여 (경희대학교 동서의학대학원) ;
  • 오명숙 (경희대학교 약학대학 한약학과)
  • Received : 2010.08.10
  • Accepted : 2010.09.13
  • Published : 2010.09.30
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Abstract

Objectives : The present study investigated the anti-nociceptive and anti-inflammatory properties of the water extract of Geranii Herba (The stem and leaves of Geranium thunbergii Sieb. et Zucc.) in the animal models of pain and inflammation. Methods : We evaluated the anti-nociceptive and anti-inflammatory activities of Geranii Herba extract (GHE) using the writhing test, tail-flick test, carrageenan-induced paw edema and xylene-induced ear edema models. Two dose of GHE (100 and 1000 mg/kg) was administrated orally to the mice. Control group received normal saline and ibuprofen (50 mg/kg) was used as a positive control drug. Results : GHE 1000 mg/kg treated group showed an increased tail-flick response time in the tail-flick test and inhibitory effect on writhing syndrome induced by acetic acid. Treatment with GHE at the same dose inhibited ear edema induced by xylene and foot edema induced by carrageenan toxicity. Conclusion : The results demonstrate that GHE has anti-nociceptive and anti-inflammatory effects in the various models of nociception and inflammation.

Keywords

References

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