The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Comparative Studies on the Hyperlipidemia of Melandrii Herba and Vaccariae Semen

장구채 전초와 맥람채 종자의 고지혈증(高脂血症)에 대한 효능 비교 연구

  • Lee, Man-Hee (Dept. of Herbology, College of Oriental Medicine, Kyungwon University) ;
  • Han, Hyo-Sang (Dept. of Herbology, College of Oriental Medicine, Kyungwon University) ;
  • Lee, Young-Jong (Dept. of Herbology, College of Oriental Medicine, Kyungwon University)
  • 이만희 (경원대학교 한의과대학 본초학교실) ;
  • 한효상 (경원대학교 한의과대학 본초학교실) ;
  • 이영종 (경원대학교 한의과대학 본초학교실)
  • Received : 2010.08.10
  • Accepted : 2010.09.13
  • Published : 2010.09.30
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Abstract

Objectives : The present study purposed to compare the effects of Melandrii Herba and Vaccariae Semen, which are used as Wang-Bul-Yu-Haeng(王不留行) with vasodilatory effect in Korea and China, respectively, on hyperlipidemia. Methods : We applied the water extract of Melandrii Herba and Vaccariae Semen to rats with hyperlipidemia induced by high-cholesterol diet and high-fructose diet and evaluated their effects. Results : While Vaccariae Semen had significant effect on the reduction of the levels of total cholesterol, LDL-cholesterol, free cholesterol, and the activation of ALT, the application of Melandrii Herba had no significant effect on the levels of total cholesterol, LDL-cholesterol, free cholesterol, neutral fat, and free fatty acid, and the activation of AST. For the rats with hypertriglyceridemia, Vaccariae Semen reduced the levels of neutral fat and total cholesterol, but did not significantly reduce the level of free fatty acid and the activation of AST and ALT. The application of Melandrii Herba did not have any significant effect on the levels of neutral fat, total cholesterol, and free fatty acid, and the activation of AST and ALT, but it increased the level of HDL cholesterol. Conclusion : Vaccariae Semen showed a possibility as a remedy for hyperlipidemia, but Melandrii Herba did not show any significant effect. Thus, based on such a difference in remedial effect between Melandrii Herba and Vaccariae Semen, they need to be distinguished in clinical application.

Keywords

References

  1. 吳普 等述, 孫星衍, 孫馮翼 輯. 神農本草經. 北京:科學技術文獻出版社. 1999 : 34.
  2. 行政院衛生署中醫藥委員會 中藥典編輯委員會 編纂. 中華民國中藥典範. 台北 : 達昌印刷有限公司. 1985 : 548, 549.
  3. 國家中醫藥管理局 中華本草編委會. 中華本草. 上海:上海科學技術出版社. 1999 ; 2 : 790, 791, 802-804.
  4. 江蘇新醫學院 編. 中藥大辭典 上冊. 上海:上海科學技術出版社. 1977 : 311-3.
  5. 지형준, 이상인, 안덕균, 이경순, 이숙연, 이영종 편. 대한 약전 및 대한약전외 한약규격주해 제2개정. 서울 : 한국메디칼인덱스사. 1998 : 275.
  6. 조선민주주의인민공화국 보건부 약전위원회. 조선민주주의 인민공화국약전 제5판. 평양 : 의학과학출판사. 1996 : 236, 237.
  7. 國家藥典委員會 編. 中華人民共和國藥典 2005年版 1部. 北京 : 化學工業出版社. 2005 : 36.
  8. 우원식, 최재수. Phytochemical Study on Melandrium firmum(3). 생약학회지 Vol.14. No.4. 한국생약학회. 1985 : 261.
  9. 우원식, 우은희. 장구채의 성분에 관한 연구(2). 생약학회지 Vol.20 No.1. 한국생약학회. 1989 : 56.
  10. Koike K, Jia Z, Nikaido T. Triterpenoid saponins from Vaccaria segetalis. Phytochemistry. Volume 47. Issue 7. 1998 : 1343-9. https://doi.org/10.1016/S0031-9422(97)00707-3
  11. Sang SM, Lao AN, Leng Y, Cao L, Chen ZL, Uzawa J, Shigeo Y, Fujimoto Y. A new triterpenoid saponin with inhibition of luteal cell from the seeds of Vaccaria segetalis. Shanghai Institute of Materia Medica. 2002 Dec : 4(4) : 297-301.
  12. Sang SM, Lao AN, Chen ZL, Uzawa J, Fujimoto Y Three new triterpenoid saponins from the seeds of Vaccaria segetalis. Shanghai Institute of Materia Medica. 2000 ; 2(3) : 187-93.
  13. Morita H, Yun YS, Takeya K, Itokawa H and Yamada K. Segetalins B, C and D, three new cyclic peptides from Vaccaria segetalis. Tetrahedron. Volume 51. Issue 21. 1995 May : 6003-14. https://doi.org/10.1016/0040-4020(95)00278-G
  14. Morita H, Yun YS, Takeya K and Itokawa H. Segetalin A, a new cyclic hexapeptide from vaccaria segetalis. Tetrahedron Letters. Volume 35. Issue 51. 1994 December : 9593-6. https://doi.org/10.1016/0040-4039(94)88519-2
  15. Shoemaker M, Hamilton B, Dairkee SH, Cohen I, Campbell MJ. In vitro anticancer activity of twelve Chinese medicinal herbs. Phytother Res. 19(7) 2005 Jul : 649-51. https://doi.org/10.1002/ptr.1702
  16. Yun YS, Morita H, Takeya K, Itokawa H. Cyclic peptides from higher plants. 34. Segetalins G and H, structures and estrogen-like activity of cyclic pentapeptides from Vaccaria segetalis. J. Nat. Prod. 1997 ; 60(3) : 216-8. https://doi.org/10.1021/np960617n
  17. Morita H, Yun YS, Takeya K, Itokawa H, Shirota O. Thionation of segetalins A and B, cyclic peptides with estrogen-like activity from seeds of Vaccaria segetalis. Bioorg. Med. Chem. 1997 ; 5(3) : 631-6. https://doi.org/10.1016/S0968-0896(97)00001-1
  18. 이광환, 이상인. 한국산 왕불유행의 약물에 관한 연구 (Comparison of Pharmacological Effects of Melandrii Herba and Semen in Korea). 경희한의대 논문집. 1984 ; 7 : 353-61.
  19. 鄭銀瑛. 王不留行과 硬葉女婁菜가 hydrocortisone acetate로 유발된 瘀血 病態에 미치는 影響. 대구한의대학교. 2005 : 17-19.
  20. 김정자. 王不留行과 硬葉女婁菜의 鎭痛, 消炎 및 抗關節炎에 대한 효능 비교연구. 東義大學校大學院. 2004 : 32.
  21. 노환성, 김운자, 박건구, 조영환, 박형섭, 고지혈증 동물 모델 설정을 위한 식이처방의 실험적 연구. 약제학회지 1994 ; 24(4) : 297-300.
  22. Elkayam A, Mirelman D, Peleg E, Wilchek M, Miron T, Rabinkov A, Sadetzki S, Rosenthal T., The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats. Am J Hypertens 2001 ; 14(4 Pt 1) : 377-381. https://doi.org/10.1016/S0895-7061(00)01298-X
  23. Dimo T, Rakotonirina A, Tan PV, Dongo E, Dongmo AB, Kamtchouing P, Azay J, Abegaz BM, Cros G, Ngadjui TB., Antihypertensive effects of Dorstenia psilurus extract in fructose-fed hyperinsulinemic, hypertensive rats. Phytomedicine 2001 ; 8(2) : 101-106. https://doi.org/10.1078/0944-7113-00014
  24. Ishida K, Sakazume M, Ikegami H, Doi K., Enhanced nephrotoxicity of acetaminophen in fructose-induced hypertrigly ceridemic rats: effect of partial hepatectomy. Exp Toxicol Pathol 1997 ; 49(5) : 321-327. https://doi.org/10.1016/S0940-2993(97)80093-0
  25. 赤松金芳. 新訂 和漢藥. 東京：醫齒藥出版株式會社. 1980 : 470, 471.
  26. 難波恒雄. 和漢藥百科圖鑑(1). 大阪 : 保育社. 1993 : 244, 245.
  27. 三橋博 監修. 原色牧野和漢藥草大圖鑑. 東京 : 北隆館. 1988 : 24, 65.
  28. 陶弘景 輯, 尙志鈞 輯校. 名醫別錄. 北京 : 人民衛生出版社. 1986 : 56, 57.
  29. 蘇頌 撰, 胡乃長, 王致譜 輯注. 圖經本草. 福州 : 福建科學技術出版社. 1988 : 122, 123.
  30. Krajcovicova, K. M. and Dibak, O., Influence of the time of intake of a high fat diet on gluconeogenesis. Physiol Bohemoslov. 1985 ; 34(4) : 339-350.

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