DOI QR코드

DOI QR Code

Effect of Red Pepper Seeds Powder on Lipid Composition in Rats Fed High-Fat.High-Cholesterol Diets

  • Received : 2010.08.10
  • Accepted : 2010.09.15
  • Published : 2010.09.30

Abstract

The purpose of the present study was to evaluate the effects of red pepper seeds powder on lipid metabolism in rats fed high fat high cholesterol diet. Rats were divided into five experimental groups: normal diet group, high fat high cholesterol diet group, high fat high cholesterol diet with 5% red pepper seeds powder supplemented group (SA group), high fat high cholesterol diet with 10% red pepper seeds powder supplemented group (SB group) and high fat high cholesterol diet with 15% red peeper seeds powder supplemented group (SC group). The serum triglyceride (TG) and cholesterol contents, and LDL-cholesterol and atherogenic index (AI) of the red pepper seed powder supplemented groups were significantly decreased compared to the HF group. The serum HDL-cholesterol contents of the red pepper seed powder supplemented groups were increased compared to the HF group. However, there was no significant difference in the serum HDL-cholesterol among all experimental groups. The hepatic TG and cholesterol contents of the red pepper seed powder supplemented groups were significantly decreased compared to the HF group. The fecal total cholesterol and triglyceride contents of the red pepper seeds powder supplemented groups were significantly increased compared to the HF group. These results suggest that supplementation of red pepper seed powder may have a pronounced impact on markers of lipid metabolism in serum and liver of rats fed high fat high cholesterol diets.

Keywords

References

  1. Lee HG. 1996. Nutritional problems in Korean; patternof disease incidence and nutrition in Korea. Korean J Nutr29: 381-383.
  2. Jang JY, Choi HJ. 2003. Effects of Artemisia iwayomogioligosaccharide on the blood lipids, abdominal adipose tissuesand leptin levels in the obese rats. Korean J Nutr36: 437-445.
  3. Bae MJ. 1991. Effects of ginseng fraction components onfat accumulation of liver in the obese rat induced by highfat dietary. J Korean Soc Food Sci Nutr 20: 27-34.
  4. Lee MS, Han MK, Lee KB, Park SS, Hong YP, An YS.2003. Effects of Chinese medical material extract on plasmalipids and glucose in male rats. Korean J Food & Nutr16: 146-151.
  5. Kang SA, Jang KH, Park SK, Lim JP, Jeon H, Cui X,Leem K. 2003. Effects of herbal composition on obeserats fed high fat diet. Kor J Herb 18: 59-64.
  6. Seung KR, Jung KH. 2001. Effect of Carthamus tinctoriusL. semen on endotoxin-induced thrombosis in rats. J AppliPharma 9: 258-262.
  7. Kim MN, Kim KH. 1992. Research for analgesic and hepatoprotectiveaction of Carthami Flos. Pusan Bull PharmSci 26: 32-36.
  8. Cho SH, Choi SW, Choi YS, Lee WJ. 2001. Effects ofdefatted safflower and perilla seed powers on lipid metabolismin ovariectomized female rats fed high cholesteroldiets. J Korean Soc Food Sci Nutr 30: 112-118.
  9. Yoo JY, Shin DH, Min BY. 1984. Composition of grapeseed oil. Korean J Food Sci Technol 16: 257-260.
  10. Normen L, Ellegard L, Brants H, Dutta P, Andersson H.2007. A phytosterol database: Fatty foods consumed inSweden and the Netherlands. J Food Compos Anal 20:193-201. https://doi.org/10.1016/j.jfca.2006.06.002
  11. Sartippour MR, Heber D, Ma J, Lu Q, Go VL, NguyenM. 2001. Green tea and its catechins inhibit breast cancerxenografts. Nutr Cancer 40: 149-156. https://doi.org/10.1207/S15327914NC402_11
  12. Moon KD, Back SS, Kim JH, Jeon SM, Lee MK, ChoiMS. 2001. Safflower seed extract lowers plasma and hepaticlipids in rats fed high-cholesterol diet. Nutr Res 21:895-904. https://doi.org/10.1016/S0271-5317(01)00293-7
  13. Van Jaarsveld H, Kuyl JM, Schulenburg DH, Wiid NM.1996. Effect of flavonoids on the outcome of myocardialmitochondrial ischemia/reperfusion injury. Res CommunMol Pathol Pharmacol 91: 65-75.
  14. Caillet S, Salmieri S, Lacroix M. 2006. Evaluation of freeradical-scavenging properties of commercial grape phenolextracts by a fast colorimetric method. Food Chem 95:1-8. https://doi.org/10.1016/j.foodchem.2004.12.011
  15. Sin MK, Han SH, Han GJ. 1997. The effect of green teaon the serum lipid and liver tissue of cholesterol fed rats.Korean J Food Sci Technol 29: 1255-1263.
  16. Lim K, Yoshiok M, Kikuzato S, Kiyonaga A, Tanaka H,Shindo M, Suzuki M. 1997. Dietary red pepper ingestionincreases carbohydrate oxidation at rest and during exercisein runners. Med Sci Sports Exerc 29: 355-361. https://doi.org/10.1097/00005768-199703000-00010
  17. Choi SM, Jeon TS, Rhee SH, Park KY. 2007. Red pepperpowder and kimchi reduce body weight and blood andtissue lipids in rats fed a high fat diet. Nutraceut Food7: 162-167. https://doi.org/10.3746/jfn.2002.7.2.162
  18. Oi T, Kawada T, Shishido C, Wada K, Kominato Y,Nishimura S, Ariga T, Iwai K. 1999. Ally-containing sulfidesin garlic increase uncoupling content in brown adiposetissue, and noradrenaline and adrenaline secretion inrats. J Nutr 129: 336-342. https://doi.org/10.1093/jn/129.2.336
  19. Yeh YY, Yeh SM. 1994. Garlic reduces plasma lipids byinhibiting hepatic and triacylglycerol synthesis. Lipids 29:189-193. https://doi.org/10.1007/BF02536728
  20. Sheo HJ. 1999. Effects of garlic on the blood lipid andother serum components in rats. J Korean Soc Food SciNutr 28: 1139-1148.
  21. Srivastava KC, Tyagi OD. 1993. Effects of garlic-derivedprinciples (ajoene) on aggregation and arachidonic acidmetabolism in human blood platelets. ProstaglandinsLeukot Essent Fatty Acids 49: 587-595. https://doi.org/10.1016/0952-3278(93)90165-S
  22. Legnari C, Frascaro M, Guazzaloca G, Ludovici S, CesaranoG, Coccheri S. 1993. Effects of a dried garlic preparationon fibrinolysis and platelet aggregation in healthysubject. Arzneimittelforschung 43: 119-122.
  23. Grundy SM. 1998. Multifactorial causation of obesity: implicationsfor prevention. Am J Clin Nutr 67: 563S-572S. https://doi.org/10.1093/ajcn/67.3.563S
  24. Chang MW, Johnson MA. 1980. Effects of garlic on carbohydratemetabolism and lipid synthesis in rats. J Nutr110: 931-936. https://doi.org/10.1093/jn/110.5.931
  25. Sim KH, Han YS. 2007. The antimutagenic and antioxidanteffects of red pepper and red pepper pericarp (Capsicumannum L.). J Food Sci Nutr 12: 273-278. https://doi.org/10.3746/JFN.2007.12.4.273
  26. Friedewald WT, Levy RI, Fedreicson DS. 1972. Estimationof the concentration of low-density lipoprotein cholesterolin plasma, without use of the preparative ultracentrifuge.Clin Chem 18: 499-502.
  27. Fiordaliso M, Kok N, Desager KP, Goethals F, DeboyserD. 1977. Estimation of the concentration of low-densitylipoprotein cholesterol in plasma. Am J Clin Nutr 30: 171. https://doi.org/10.1093/ajcn/30.2.171
  28. Folch JM, Lee M, Stanley GHS. 1957. A simple methodfor the isolation and purification of total lipids from animaltissue. J Biol Chem 26: 497-509.
  29. Sale FD, Marchesini S, Fishman PH, Berra B. 1984. Asensitive enzymatic assay for determination of cholesterolin lipid extracts. Academic Press Inc, NY, USA. p 347-350.
  30. Sreel RGD, Torrie JH. 1990. Principles and proceduresof statistics. McGrow Hill, New York, USA. p 187, 287.
  31. Kaewprasert S, Okada M, Aoyama Y. 2001. Nutritionaleffects of cyclodextrins on liver and serum lipids and cecalorganic acids in rats. J Nutr Sci Vitaminol (Tokyo) 47:335-339. https://doi.org/10.3177/jnsv.47.335
  32. Schaefer EJ. 1995. Lipoproteins, nutrition, aging andatherosclerosis. Am J Clin Nutr 61: 726. https://doi.org/10.1093/ajcn/61.3.726S
  33. Chung KH, Cho SH, Sin EN, Choi KH, Choi YS. 1988.Effects of alcohol consumption and fat content in diet onchemical composition and morphology of liver in rat.Korean J Nutr 21: 154.
  34. Vahouny GV, Roy T, Gallo LL, Story J, Kritchevsky D,Cassidy M, Grund BM, Treadwell CR. 1978. Dietary fiberand lymphatic absorption of cholesterol in the rat. Am JClin Nutr 31: 208-212. https://doi.org/10.1093/ajcn/31.10.S208

Cited by

  1. Effects of Ethanol Extracts from Red Pepper (Capsicum annuum L.) Seeds on Cholesterol Adsorption Capacity and UDP-Glucuronyl Transferase Activity vol.21, pp.6, 2011, https://doi.org/10.5352/JLS.2011.21.6.829
  2. Variations in the Efficacy of Resistant Maltodextrin on Body Fat Reduction in Rats Fed Different High-Fat Models vol.62, pp.1, 2014, https://doi.org/10.1021/jf404809v