Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Effects of Korean Red Ginseng on Dry Mouth: A Randomized, Double-Blind, Placebo-Controlled Trial

  • Park, Jae-Woo (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Lee, Beom-Joon (Department of Internal Medicine, Kangnam Korean Hospital, Kyung Hee University) ;
  • Bu, Young-Min (Department of Herbal Pharmacology, College of Oriental Medicine, Kyung Hee University) ;
  • Yeo, In-Kwon (Department of Statistics, Sookmyung Women's University) ;
  • Kim, Jin-Sung (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University) ;
  • Ryu, Bong-Ha (Department of Internal Medicine, College of Oriental Medicine, Kyung Hee University)
  • Received : 2010.03.16
  • Accepted : 2010.05.26
  • Published : 2010.09.30
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Abstract

Dry mouth is easily neglected if not associated with oral diseases. Consequently, xerostomatic patients often use unconventional therapies. In traditional Korean medicine, Korean red ginseng (KRG) has long been used to relieve dry mouth. However, no clinical trials have investigated whether KRG actually has an effect on dry mouth. This study was performed to evaluate the efficacy of KRG for dry mouth. We enrolled 100 volunteers with no obvious oral or salivary gland diseases and divided them into KRG and placebo groups. Each group was divided into six subgroups according to age and gender. The subjects received 6 g/day of KRG or placebo for 8 weeks. The dry mouth visual analog scale (VAS), salivary flow rate, and a dry mouth-related symptom questionnaire were evaluated at baseline and at 4 and 8 weeks. KRG treatment did not show any significant differences for any of the variables. However, KRG improved the dry mouth VAS at 4 weeks and dry mouthrelated symptoms at 8 weeks in women, but not in men. Subgroup analyses revealed that KRG markedly improved the dry mouth VAS in women of menopausal age (40 to 59 years) at 4 and 8 weeks. KRG may have beneficial effects for dry mouth in women, especially those of menopausal age, but not in men. Further investigation in post- and perimenopausal women is required to elaborate on these findings.

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References

  1. Sreebny LM, Valdini A. Xerostomia: a neglected symptom. Arch Intern Med 1987;147:1333-1337. https://doi.org/10.1001/archinte.147.7.1333
  2. Narhi TO. Prevalence of subjective feelings of dry mouth in the elderly. J Dent Res 1994;73:20-25. https://doi.org/10.1177/00220345940730010301
  3. Sreebny LM, Schwartz SS. A reference guide to drugs and dry mouth-2nd edition. Gerodontology 1997;14:33-47. https://doi.org/10.1111/j.1741-2358.1997.00033.x
  4. Torres SR, Peixoto CB, Caldas DM, Silva EB, Akiti T, Nucci M, de Uzeda M. Relationship between salivary flow rates and Candida counts in subjects with xerostomia. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002;93:149-154. https://doi.org/10.1067/moe.2002.119738
  5. Dodds MW, Hsieh SC, Johnson DA. The effect of increased mastication by daily gum-chewing on salivary gland output and dental plaque acidogenicity. J Dent Res 1991;70:1474-1478. https://doi.org/10.1177/00220345910700120101
  6. Samarawickrama DY. Saliva substitutes: how effective and safe are they? Oral Dis 2002;8:177-179. https://doi.org/10.1034/j.1601-0825.2002.02848.x
  7. Wu CH, Hsieh SC, Lee KL, Li KJ, Lu MC, Yu CL. Pilocarpine hydrochloride for the treatment of xerostomia in patients with Sjögren’s syndrome in Taiwan-a double-blind, placebo-controlled trial. J Formos Med Assoc 2006;105:796-803. https://doi.org/10.1016/S0929-6646(09)60266-7
  8. Gil-Montoya JA, Guardia-López I, Gonzalez-Moles MA. Evaluation of the clinical efficacy of a mouthwash and oral gel containing the antimicrobial proteins lactoperoxidase, lysozyme and lactoferrin in elderly patients with dry mouth-a pilot study. Gerodontology 2008;25:3-9. https://doi.org/10.1111/j.1741-2358.2007.00197.x
  9. Ship JA, Pillemer SR, Baum BJ. Xerostomia and the geriatric patient. J Am Geriatr Soc 2002;50:535-543. https://doi.org/10.1046/j.1532-5415.2002.50123.x
  10. Nagler RM. Salivary glands and the aging process: mechanistic aspects, health-status and medicinal-efficacy monitoring. Biogerontology 2004;5:223-233. https://doi.org/10.1023/B:BGEN.0000038023.36727.50
  11. Kagami H, Horie K, Nishiguchi H, Shigetomi T, Ueda M. Effect of ‘bakumondo-to’, a Chinese-Japanese herbal medicine, on cultured and dispersed salivary gland cells. J Ethnopharmacol 1996;53:89-95.
  12. Sugano S, Takeyama I, Ogino S, Kenmochi M, Kaneko T. Effectiveness of formula ophiopogoins in the treatment of xerostomia and pharyngoxerosis. Acta Otolaryngol Suppl 1996;522:124-129.
  13. Johansson G, Andersson G, Edwardsson S, Bjorn AL, Manthorpe R, Attstrom R. Effects of mouthrinses with linseed extract Salinum without/with chlorhexidine on oral conditions in patients with Sjogren’s syndrome: a double-blind crossover investigation. Gerodontology 2001;18:87-94. https://doi.org/10.1111/j.1741-2358.2001.00087.x
  14. Haila S, Koskinen A, Tenovuo J. Effects of homeopathic treatment on salivary flow rate and subjective symptoms in patients with oral dryness: a randomized trial. Homeopathy 2005;94:175-181. https://doi.org/10.1016/j.homp.2005.03.002
  15. Yanagi Y, Yasuda M, Hashida K, Kadokura Y, Yamamoto T, Suzaki H. Mechanism of salivary secretion enhancement by Byakkokaninjinto. Biol Pharm Bull 2008;31:431-435. https://doi.org/10.1248/bpb.31.431
  16. Tode T, Kikuchi Y, Hirata J, Kita T, Nakata H, Nagata I. Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes. Int J Gynaecol Obstet 1999;67:169-174. https://doi.org/10.1016/S0020-7292(99)00168-X
  17. Hong B, Ji YH, Hong JH, Nam KY, Ahn TY. A double-blind crossover study evaluating the efficacy of korean red ginseng in patients with erectile dysfunction: a preliminary report. J Urol 2002;168:2070-2073. https://doi.org/10.1016/S0022-5347(05)64298-X
  18. Liou CJ, Huang WC, Tseng J. Long-term oral administration of ginseng extract modulates humoral immune response and spleen cell functions. Am J Chin Med 2005;33:651-661. https://doi.org/10.1142/S0192415X05003247
  19. Lee BJ, Heo H, Oh SC, Lew JH. Comparison study of Korean and Chinese ginsengs on the regulation of lymphocyte proliferation and cytokine production. J Ginseng Res 2008;32:250-256. https://doi.org/10.5142/JGR.2008.32.3.250
  20. Kim DI, Choi MS, Ahn HY. Efficacy and safety of red ginseng on women’s health related quality of life and sexual function. J Ginseng Res 2009;33:115-126. https://doi.org/10.5142/JGR.2009.33.2.115
  21. Shim MK, Lee YJ. Ginseng as a complementary and alternative medicine for postmenopausal symptoms. J Ginseng Res 2009;33:89-92. https://doi.org/10.5142/JGR.2009.33.2.089
  22. Fox PC, Busch KA, Baum BJ. Subjective reports of xerostomia and objective measures of salivary gland performance. J Am Dent Assoc 1987;115:581-584. https://doi.org/10.1016/S0002-8177(87)54012-0
  23. Percival RS, Challacombe SJ, Marsh PD. Flow rates of resting whole and stimulated parotid saliva in relation to age and gender. J Dent Res 1994;73:1416-1420. https://doi.org/10.1177/00220345940730080401
  24. Frutos R, Rodriguez S, Miralles-Jorda L, Machuca G. Oral manifestations and dental treatment in menopause. Med Oral 2002;7:26-35.
  25. Rivera Gomez B, Hernandez Vallejo G, Arriba de la Fuente L, Lopez Cantor M, Diaz M, Lopez Pintor RM. The relationship between the levels of salivary cortisol and the presence of xerostomia in menopausal women: a preliminary study. Med Oral Patol Oral Cir Bucal 2006;11:E407-E412.
  26. Forabosco A, Criscuolo M, Coukos G, Uccelli E, Weinstein R, Spinato S, Botticelli A, Volpe A. Efficacy of hormone replacement therapy in postmenopausal women with oral discomfort. Oral Surg Oral Med Oral Pathol 1992;73:570-574. https://doi.org/10.1016/0030-4220(92)90100-5
  27. Chen WY. Exogenous and endogenous hormones and breast cancer. Best Pract Res Clin Endocrinol Metab 2008;22:573-585. https://doi.org/10.1016/j.beem.2008.08.001
  28. Ellis JM, Reddy P. Effects of Panax ginseng on quality of life. Ann Pharmacother 2002;36:375-379. https://doi.org/10.1345/aph.1A245
  29. Kaplan I, Zuk-Paz L, Wolff A. Association between salivary flow rates, oral symptoms, and oral mucosal status. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;106:235-241. https://doi.org/10.1016/j.tripleo.2007.11.029
  30. Wolff M, Kleinberg I. Oral mucosal wetness in hypo- and normosalivators. Arch Oral Biol 1998;43:455-462. https://doi.org/10.1016/S0003-9969(98)00022-3
  31. Atkinson JC, Grisius M, Massey W. Salivary hypofunction and xerostomia: diagnosis and treatment. Dent Clin North Am 2005;49:309-326. https://doi.org/10.1016/j.cden.2004.10.002
  32. Kim HY, Kang KS, Yamabe N, Yokozawa T. Comparison of the effects of Korean ginseng and heat-processed Korean ginseng on diabetic oxidative stress. Am J Chin Med 2008;36:989-1004. https://doi.org/10.1142/S0192415X08006417

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