DOI QR코드

DOI QR Code

Biological Characteristics of Rotator Cuff Tendon

회전근 개의 생물학적 특성

  • Park, Hyung-Bin (Department of Orthopaedic Surgery, School of Medicine, Gyeongsang National University) ;
  • Sung, Chang-Meen (Department of Orthopaedic Surgery, School of Medicine, Gyeongsang National University)
  • 박형빈 (경상대학교 의학전문대학원 정형외과학교실) ;
  • 성창민 (경상대학교 의학전문대학원 정형외과학교실)
  • Received : 2010.05.14
  • Accepted : 2010.06.16
  • Published : 2010.06.15

Abstract

Purpose: Rotator cuff disease is the most common shoulder disease. Rotator cuff tear, which is related to cuff tendon degeneration, is commonly encountered in clinical practice. Materials and Methods: Knowledge about the biology of the normal rotator cuff is fundamental to understanding the pathophysiology of and degenerative processes in rotator cuff tendon tears. Furthermore, such basic knowledge provides a rationale for and facilitates the development of treatment modalities. Results and Conclusion: Therefore, we reviewed the biology of the normal rotator cuff tendon, theories to explain the pathophysiology of rotator cuff tendon tear, and current research on apoptosis of rotator cuff tenofibroblasts.

목적: 회전근 개의 질환은 견관절 질환 중 가장 흔하며, 퇴행성 변화와 관련한 회전근 개 파열은 임상에서 가장 흔히 경험하는 질환이다. 대상 및 방법: 회전근 개의 정상적인 생물학적 특성을 이해하는 것은 회전근 개의 퇴행성 변화를 이해하고, 병태생리를 이해하는 것에 도움이 되며 나아가서 새로운 치료방법이나 예방법을 발전시키는 기초 지식으로 중요하다 하겠다. 결과 및 결론: 이에 저자들은 회전근 개의 생물학적 정상소견과, 회전근 개 파열의 병리를 설명하는 이론에 대한 문헌 고찰과 최근 활발히 연구되고 있는 회전근 개 건섬유모세포의 세포자멸 기전등에 관한 문헌고찰 내용을 보고하고자 한다.

Keywords

References

  1. Bi Y, Ehirchiou D, Kilts TM, et al.: Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat Med, 13: 1219-1227, 2007. https://doi.org/10.1038/nm1630
  2. Blevins FT, Djurasovic M, Flatow EL, Vogel KG: Biology of the rotator cuff tendon. Orthop Clin North Am, 28: 1-16, 1997. https://doi.org/10.1016/S0030-5898(05)70260-1
  3. Brooks CH, Revell WJ, Heatley FW: A quantitative histological study of the vascularity of the rotator cuff tendon. J Bone Joint Surg Br, 74: 151-153, 1992.
  4. Carpenter JE, Flanagan CL, Thomopoulos S, Yian EH, Soslowsky LJ: The effects of overuse combined with intrinsic or extrinsic alterations in an animal model of rotator cuff tendinosis. Am J Sports Med, 26: 801-807, 1998.
  5. Chard MD, Cawston TE, Riley GP, Gresham GA, Hazleman BL: Rotator cuff degeneration and lateral epicondylitis: a comparative histological study. Ann Rheum Dis, 53: 30-34, 1994. https://doi.org/10.1136/ard.53.1.30
  6. Clark JM, Harryman DT, 2nd: Tendons, ligaments, and capsule of the rotator cuff. Gross and microscopic anatomy. J Bone Joint Surg Am, 74: 713-725, 1992.
  7. Fallon J, Blevins FT, Vogel K, Trotter J: Functional morphology of the supraspinatus tendon. J Orthop Res, 20: 920-926, 2002. https://doi.org/10.1016/S0736-0266(02)00032-2
  8. Kumagai J, Sarkar K, Uhthoff HK: The collagen types in the attachment zone of rotator cuff tendons in the elderly: an immunohistochemical study. J Rheumatol, 21: 2096-2100, 1994.
  9. McNeilly CM, Banes AJ, Benjamin M, Ralphs JR: Tendon cells in vivo form a three dimensional network of cell processes linked by gap junctions. J Anat, 189 ( Pt 3): 593-600, 1996.
  10. Milgrom C, Schaffler M, Gilbert S, van Holsbeeck M: Rotator-cuff changes in asymptomatic adults. The effect of age, hand dominance and gender. J Bone Joint Surg Br, 77: 296-298, 1995.
  11. Millar NL, Wei AQ, Molloy TJ, Bonar F, Murrell GA: Cytokines and apoptosis in supraspinatus tendinopathy. J Bone Joint Surg Br, 91: 417-424, 2009. https://doi.org/10.1302/0301-620X.91B3.21652
  12. Millar NL, Wei AQ, Molloy TJ, Bonar F, Murrell GA: Heat shock protein and apoptosis in supraspinatus tendinopathy. Clin Orthop Relat Res, 466: 1569-1576, 2008. https://doi.org/10.1007/s11999-008-0265-9
  13. Molloy TJ, Kemp MW, Wang Y, Murrell GA: Microarray analysis of the tendinopathic rat supraspinatus tendon: glutamate signaling and its potential role in tendon degeneration. J Appl Physiol, 101: 1702-1709, 2006. https://doi.org/10.1152/japplphysiol.00386.2006
  14. Moseley HF, Goldie I: The Arterial Pattern of the Rotator Cuff of the Shoulder. J Bone Joint Surg Br, 45: 780-789, 1963.
  15. Park HB, Hah YS, Yang JW, Nam JB, Cho SH, Jeong ST: Antiapoptotic effects of anthocyanins on rotator cuff tenofibroblasts. J Orthop Res, Epub ahead of print, 2010.
  16. Perry SM, McIlhenny SE, Hoffman MC, Soslowsky LJ: Inflammatory and angiogenic mRNA levels are altered in a supraspinatus tendon overuse animal model. J Shoulder Elbow Surg, 14: 79S-83S, 2005. https://doi.org/10.1016/j.jse.2004.09.020
  17. Premdas J, Tang JB, Warner JP, Murray MM, Spector M: The presence of smooth muscle actin in fibroblasts in the torn human rotator cuff. J Orthop Res, 19: 221-228, 2001. https://doi.org/10.1016/S0736-0266(00)90011-1
  18. Rathbun JB, Macnab I: The microvascular pattern of the rotator cuff. J Bone Joint Surg Br, 52: 540-553, 1970.
  19. Riley GP, Harrall RL, Constant CR, Chard MD, Cawston TE, Hazleman BL: Glycosaminoglycans of human rotator cuff tendons: changes with age and in chronic rotator cuff tendinitis. Ann Rheum Dis, 53: 367-376, 1994. https://doi.org/10.1136/ard.53.6.367
  20. Riley GP, Harrall RL, Constant CR, Chard MD, Cawston TE, Hazleman BL: Tendon degeneration and chronic shoulder pain: changes in the collagen composition of the human rotator cuff tendons in rotator cuff tendinitis. Ann Rheum Dis, 53: 359-366, 1994. https://doi.org/10.1136/ard.53.6.359
  21. Rothman RH, Parke WW: The vascular anatomy of the rotator cuff. Clin Orthop Relat Res, 41: 176-186, 1965.
  22. Soslowsky LJ, Thomopoulos S, Esmail A, et al.: Rotator cuff tendinosis in an animal model: role of extrinsic and overuse factors. Ann Biomed Eng, 30: 1057-1063, 2002. https://doi.org/10.1114/1.1509765
  23. Soslowsky LJ, Thomopoulos S, Tun S, et al.: Neer Award 1999. Overuse activity injures the supraspinatus tendon in an animal model: a histologic and biomechanical study. J Shoulder Elbow Surg, 9: 79-84, 2000. https://doi.org/10.1016/S1058-2746(00)90033-8
  24. Szomor ZL, Appleyard RC, Murrell GA: Overexpression of nitric oxide synthases in tendon overuse. J Orthop Res, 24: 80-86, 2006. https://doi.org/10.1002/jor.20009
  25. Tomonaga A, Hamada K, Gotoh M, Yamakawa H, Kobayashi K, Fukuda H: Expression of procollagen alpha 1 type III mRNA in rotator cuff tears. Tokai J Exp Clin Med, 25: 125-134, 2000.
  26. Tuoheti Y, Itoi E, Pradhan RL, et al.: Apoptosis in the supraspinatus tendon with stage II subacromial impingement. J Shoulder Elbow Surg, 14: 535-541, 2005. https://doi.org/10.1016/j.jse.2005.01.001
  27. Yuan J, Murrell GA, Trickett A, Wang MX: Involvement of cytochrome c release and caspase-3 activation in the oxidative stress-induced apoptosis in human tendon fibroblasts. Biochim Biophys Acta, 1641: 35-41, 2003. https://doi.org/10.1016/S0167-4889(03)00047-8
  28. Yuan J, Murrell GA, Wei AQ and Wang MX: Apoptosis in rotator cuff tendonopathy. J Orthop Res, 20: 1372-1379, 2002. https://doi.org/10.1016/S0736-0266(02)00075-X
  29. Yuan J, Wang MX and Murrell GA: Cell death and tendinopathy. Clin Sports Med, 22: 693-701, 2003. https://doi.org/10.1016/S0278-5919(03)00049-8