DOI QR코드

DOI QR Code

회전근 개의 생물학적 특성

Biological Characteristics of Rotator Cuff Tendon

  • 박형빈 (경상대학교 의학전문대학원 정형외과학교실) ;
  • 성창민 (경상대학교 의학전문대학원 정형외과학교실)
  • Park, Hyung-Bin (Department of Orthopaedic Surgery, School of Medicine, Gyeongsang National University) ;
  • Sung, Chang-Meen (Department of Orthopaedic Surgery, School of Medicine, Gyeongsang National University)
  • 투고 : 2010.05.14
  • 심사 : 2010.06.16
  • 발행 : 2010.06.15

초록

목적: 회전근 개의 질환은 견관절 질환 중 가장 흔하며, 퇴행성 변화와 관련한 회전근 개 파열은 임상에서 가장 흔히 경험하는 질환이다. 대상 및 방법: 회전근 개의 정상적인 생물학적 특성을 이해하는 것은 회전근 개의 퇴행성 변화를 이해하고, 병태생리를 이해하는 것에 도움이 되며 나아가서 새로운 치료방법이나 예방법을 발전시키는 기초 지식으로 중요하다 하겠다. 결과 및 결론: 이에 저자들은 회전근 개의 생물학적 정상소견과, 회전근 개 파열의 병리를 설명하는 이론에 대한 문헌 고찰과 최근 활발히 연구되고 있는 회전근 개 건섬유모세포의 세포자멸 기전등에 관한 문헌고찰 내용을 보고하고자 한다.

Purpose: Rotator cuff disease is the most common shoulder disease. Rotator cuff tear, which is related to cuff tendon degeneration, is commonly encountered in clinical practice. Materials and Methods: Knowledge about the biology of the normal rotator cuff is fundamental to understanding the pathophysiology of and degenerative processes in rotator cuff tendon tears. Furthermore, such basic knowledge provides a rationale for and facilitates the development of treatment modalities. Results and Conclusion: Therefore, we reviewed the biology of the normal rotator cuff tendon, theories to explain the pathophysiology of rotator cuff tendon tear, and current research on apoptosis of rotator cuff tenofibroblasts.

키워드

참고문헌

  1. Bi Y, Ehirchiou D, Kilts TM, et al.: Identification of tendon stem/progenitor cells and the role of the extracellular matrix in their niche. Nat Med, 13: 1219-1227, 2007. https://doi.org/10.1038/nm1630
  2. Blevins FT, Djurasovic M, Flatow EL, Vogel KG: Biology of the rotator cuff tendon. Orthop Clin North Am, 28: 1-16, 1997. https://doi.org/10.1016/S0030-5898(05)70260-1
  3. Brooks CH, Revell WJ, Heatley FW: A quantitative histological study of the vascularity of the rotator cuff tendon. J Bone Joint Surg Br, 74: 151-153, 1992.
  4. Carpenter JE, Flanagan CL, Thomopoulos S, Yian EH, Soslowsky LJ: The effects of overuse combined with intrinsic or extrinsic alterations in an animal model of rotator cuff tendinosis. Am J Sports Med, 26: 801-807, 1998.
  5. Chard MD, Cawston TE, Riley GP, Gresham GA, Hazleman BL: Rotator cuff degeneration and lateral epicondylitis: a comparative histological study. Ann Rheum Dis, 53: 30-34, 1994. https://doi.org/10.1136/ard.53.1.30
  6. Clark JM, Harryman DT, 2nd: Tendons, ligaments, and capsule of the rotator cuff. Gross and microscopic anatomy. J Bone Joint Surg Am, 74: 713-725, 1992.
  7. Fallon J, Blevins FT, Vogel K, Trotter J: Functional morphology of the supraspinatus tendon. J Orthop Res, 20: 920-926, 2002. https://doi.org/10.1016/S0736-0266(02)00032-2
  8. Kumagai J, Sarkar K, Uhthoff HK: The collagen types in the attachment zone of rotator cuff tendons in the elderly: an immunohistochemical study. J Rheumatol, 21: 2096-2100, 1994.
  9. McNeilly CM, Banes AJ, Benjamin M, Ralphs JR: Tendon cells in vivo form a three dimensional network of cell processes linked by gap junctions. J Anat, 189 ( Pt 3): 593-600, 1996.
  10. Milgrom C, Schaffler M, Gilbert S, van Holsbeeck M: Rotator-cuff changes in asymptomatic adults. The effect of age, hand dominance and gender. J Bone Joint Surg Br, 77: 296-298, 1995.
  11. Millar NL, Wei AQ, Molloy TJ, Bonar F, Murrell GA: Cytokines and apoptosis in supraspinatus tendinopathy. J Bone Joint Surg Br, 91: 417-424, 2009. https://doi.org/10.1302/0301-620X.91B3.21652
  12. Millar NL, Wei AQ, Molloy TJ, Bonar F, Murrell GA: Heat shock protein and apoptosis in supraspinatus tendinopathy. Clin Orthop Relat Res, 466: 1569-1576, 2008. https://doi.org/10.1007/s11999-008-0265-9
  13. Molloy TJ, Kemp MW, Wang Y, Murrell GA: Microarray analysis of the tendinopathic rat supraspinatus tendon: glutamate signaling and its potential role in tendon degeneration. J Appl Physiol, 101: 1702-1709, 2006. https://doi.org/10.1152/japplphysiol.00386.2006
  14. Moseley HF, Goldie I: The Arterial Pattern of the Rotator Cuff of the Shoulder. J Bone Joint Surg Br, 45: 780-789, 1963.
  15. Park HB, Hah YS, Yang JW, Nam JB, Cho SH, Jeong ST: Antiapoptotic effects of anthocyanins on rotator cuff tenofibroblasts. J Orthop Res, Epub ahead of print, 2010.
  16. Perry SM, McIlhenny SE, Hoffman MC, Soslowsky LJ: Inflammatory and angiogenic mRNA levels are altered in a supraspinatus tendon overuse animal model. J Shoulder Elbow Surg, 14: 79S-83S, 2005. https://doi.org/10.1016/j.jse.2004.09.020
  17. Premdas J, Tang JB, Warner JP, Murray MM, Spector M: The presence of smooth muscle actin in fibroblasts in the torn human rotator cuff. J Orthop Res, 19: 221-228, 2001. https://doi.org/10.1016/S0736-0266(00)90011-1
  18. Rathbun JB, Macnab I: The microvascular pattern of the rotator cuff. J Bone Joint Surg Br, 52: 540-553, 1970.
  19. Riley GP, Harrall RL, Constant CR, Chard MD, Cawston TE, Hazleman BL: Glycosaminoglycans of human rotator cuff tendons: changes with age and in chronic rotator cuff tendinitis. Ann Rheum Dis, 53: 367-376, 1994. https://doi.org/10.1136/ard.53.6.367
  20. Riley GP, Harrall RL, Constant CR, Chard MD, Cawston TE, Hazleman BL: Tendon degeneration and chronic shoulder pain: changes in the collagen composition of the human rotator cuff tendons in rotator cuff tendinitis. Ann Rheum Dis, 53: 359-366, 1994. https://doi.org/10.1136/ard.53.6.359
  21. Rothman RH, Parke WW: The vascular anatomy of the rotator cuff. Clin Orthop Relat Res, 41: 176-186, 1965.
  22. Soslowsky LJ, Thomopoulos S, Esmail A, et al.: Rotator cuff tendinosis in an animal model: role of extrinsic and overuse factors. Ann Biomed Eng, 30: 1057-1063, 2002. https://doi.org/10.1114/1.1509765
  23. Soslowsky LJ, Thomopoulos S, Tun S, et al.: Neer Award 1999. Overuse activity injures the supraspinatus tendon in an animal model: a histologic and biomechanical study. J Shoulder Elbow Surg, 9: 79-84, 2000. https://doi.org/10.1016/S1058-2746(00)90033-8
  24. Szomor ZL, Appleyard RC, Murrell GA: Overexpression of nitric oxide synthases in tendon overuse. J Orthop Res, 24: 80-86, 2006. https://doi.org/10.1002/jor.20009
  25. Tomonaga A, Hamada K, Gotoh M, Yamakawa H, Kobayashi K, Fukuda H: Expression of procollagen alpha 1 type III mRNA in rotator cuff tears. Tokai J Exp Clin Med, 25: 125-134, 2000.
  26. Tuoheti Y, Itoi E, Pradhan RL, et al.: Apoptosis in the supraspinatus tendon with stage II subacromial impingement. J Shoulder Elbow Surg, 14: 535-541, 2005. https://doi.org/10.1016/j.jse.2005.01.001
  27. Yuan J, Murrell GA, Trickett A, Wang MX: Involvement of cytochrome c release and caspase-3 activation in the oxidative stress-induced apoptosis in human tendon fibroblasts. Biochim Biophys Acta, 1641: 35-41, 2003. https://doi.org/10.1016/S0167-4889(03)00047-8
  28. Yuan J, Murrell GA, Wei AQ and Wang MX: Apoptosis in rotator cuff tendonopathy. J Orthop Res, 20: 1372-1379, 2002. https://doi.org/10.1016/S0736-0266(02)00075-X
  29. Yuan J, Wang MX and Murrell GA: Cell death and tendinopathy. Clin Sports Med, 22: 693-701, 2003. https://doi.org/10.1016/S0278-5919(03)00049-8