Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Two Cyanidin compound from the Fruits of Acanthopanax divaricatus var. albeofructus

  • Hahn, Dug-Ryong (Laboratory of Native Korean Acanthopanacis remedies production Co) ;
  • Park, Seon-Jin (Laboratory of Native Korean Acanthopanacis remedies production Co)
  • Received : 2010.07.26
  • Accepted : 2010.09.16
  • Published : 2010.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Acanthopanax divaricatus var. albeofructus is one of the indigenous medicinal plant and the fruits of Acanthopanax spp. used as a remedial for "wipe out evil wind". Two anthocyanin were isolated from the fruits of Acanthopanax divaricatus var. albeofructus. Their structures were elucidated as cyanidin 3-lathyroside (1) and cyanidin 3-galactoside (2) by chemicophysical and spectroscopic analysis. And also, four chemical, syringin, chlorogenic acid, caffeic acid and acanthoside D were identified. Both anthocyanide were isolated for the first time from Acanthopanax species. cyanidin 3-lathyroside is one of the rare anthocyanin in natural resources.

Keywords

References

  1. Davydov, M. and Krikorian, A., Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. (Araliaceae) as an adaptogen: a closer look. J. Ethnopharmacol. 72, 345-393 (2000). https://doi.org/10.1016/S0378-8741(00)00181-1
  2. Ishikura, N., Anthocyanin of Acanthopanax divaricatus. Phytochem. 14, 1439 (1975). https://doi.org/10.1016/S0031-9422(00)98652-7
  3. Jan, O. and Jean, C.S., Anthocyanins in fruits of Aronia Melanocarpa. J. Food sci. 53, 1241-1242 (1988). https://doi.org/10.1111/j.1365-2621.1988.tb13577.x
  4. Jun, Y.-Y., Cui, C.-B., Lee, H.-J., Moon, S.-Y., Lee, D.-S., and Ham, S.-S., Antimutagenic and cytotoxicity effects of extracts of Eleutherococcus senticosus Maxim fruits. Kor. J. Food pres. 10, 394-400 (2003).
  5. Kawano, K. and Sakamura, S., Cyanidin[O-$\beta$-D-Xylophyranosyl(1-> 2)- $\beta$-D-galactophyranoside] from Aralia elata and A. cordata. Agric. Biol. Chem. 36, 27-32 (1972). https://doi.org/10.1271/bbb1961.36.27
  6. Kim, J.-Y. and Yang, K.-S., Antioxidantive activities of triterpenoids and lignans from Acanthopanax divaricatus var. albeofructus. Yakhak Hoeji 49, 236-240 (2004).
  7. Kim, M.-K., Jin, Y.-S., Heo, S.-I., Shim, T.-H., Sa, J.-H., and Wang, M.- H., Studies for component analysis and anti-oxidant effect, antimicrobial activity in Acanthopanax senticosus HARMS. Kor. J. Pharmacogn. 37, 151-156 (2006).
  8. Lee, S., Kim, B.-K., Cho, S.H., and Shin, K.H., Phytochemical constituents from the fruits of Acanthopanax sessiliflorus. Arch. Pharm. Res. 25, 280-284 (2002). https://doi.org/10.1007/BF02976626
  9. Li, S.C., 1518-1593 Bencao Gangmu (Compendium of Materia Medica) vol. 36. p26 (Published by KO MUN SA, 1993)
  10. Lyu, S.-Y., Kim, J.-Y., Noh, B., and Park, W.-B., Antioxidantive activity of water extract of different parts of Acanthopanax divaricutus var. albeofructus. Yakhak Hoeji 50, 191-198 (2006).
  11. Lyu, S., Noh, B., and Park, W.B., Modulation of Th1/Th2 cytokine secretion in a human peripheral blood mononuclear cell by water extract of Acanthopanax divaricatus var. albeofructus fruits. Yakhak Hoeji 52, 27-32 (2006).
  12. Matsumoto, K., Kasai, R., and Kanamaru, F., 3,4-Secolupane-type triterpene glycosyl ester from leaves of Acanthopanax divaricatus SEEM. Chem. Pharm. Bull. 35, 413-415 (1987). https://doi.org/10.1248/cpb.35.413
  13. Miyakoshi, M., Shirasuna, K., Sawada, H., Isoda, S., Ida, Y., and Shoji, J. Constituents of Acanthopanax divaricatus and A. sieboldianus roots. Nat. Med. 49, 218 (1995).
  14. Nam, S.G., Yook, C.S., Kim, I.S., Choi, H.S., and Park, S.Y., Studies on the constituents of the Leaves of Acanthopanax divaricatus forma flavi-flos. Nat. Prod. Sci. 12, 119-121 (2006).
  15. Oh, O.-J., Chang, S.-Y., Kim, T.-H., Yang, K.-S., Yook, C.-S., Park, S.-Y., and Nohara, T., Constituents of Acanthopanax divaricatus var. albeofructus. Nat. Med. 54, 29-32 (2000a).
  16. Oh, O.-J., Chang, S.-Y., Yook, C.-S., Yang, K.-S., Park, S.-Y., and Nohara, T., Two 3,4-seco-lupane triterpenes from leaves of Acanthopanax divaricatus var. albeofructus. Chem. Pharm. Bull. 8, 879-881 (2000b).
  17. Sakamura, A. and Kawano, K., Cyanidin 3-xylosylgalactoside, an anthocyanin from Aralia elata and A. cordata. Phytochem. 9, 1147 (1970). https://doi.org/10.1016/S0031-9422(00)85243-7
  18. Shin, E.-T., Kim, C.-J., and Yook, C.-S., Studies on the chemical constituents of Acanthopanax Fruits. Bull. K. H. Pharma. Sci. 20, 63- 73 (1992).
  19. Shin, K.H. and Lee, S.H., The chemistry of secondary product from Acanthopanax species and their pharmacological activities. Nat. Prod. Sci. 8, 111-126 (2002).
  20. Shirasuna, K., Miyakoshi, M., Mimoto, S., Isoda, S., Satoh, Y., Hirai, Y., Ida, Y., and Shoji, J. Lupane triterpenoid glycosyl esters from leaves of Acanthopanax divaricatus. Phytochem. 45, 579-584 (1997). https://doi.org/10.1016/S0031-9422(97)00017-4
  21. Terahara N., Saito N., Toki K., Sakata Y., and Honda T., Cyanidin 3- lathyroside from berries of Fetasia japonica. Phytochem. 31, 1446- 1448 (1992). https://doi.org/10.1016/0031-9422(92)80318-9
  22. Yook, C.S., Rho, Y.S., Seo, S.H., Leem, J.Y., and Han, D.R., Chemical Components of Acanthopanax divaricatus and anticancer effect in leaves. Yakhak Hoeji 40, 251-261 (1996).
  23. Zu, S.M. and Yang, K.S., Anti-lipid peroxidation activity of Acanthopanax divaricatus var. albeofructus. Yakhak Hoeji 48, 99-103 (2004).